Results 51 to 60 of about 983,540 (218)

Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age

New England Journal of Medicine, 2022
Background Vaccination of children to prevent coronavirus disease 2019 (Covid-19) is an urgent public health need. The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in children 6 to 11 years of age are unknown.
C. Creech, E. Anderson, V. Berthaud, I. Yildirim, A. Atz, Ivan Melendez Baez, D. Finkelstein, P. Pickrell, Judith L. Kirstein, C. Yut, Ronald Blair, R. Clifford, Michael Dunn, J. Campbell, D. Montefiori, J. Tomassini, Xiaoping Zhao, W. Deng, Honghong Zhou, Daniela Ramirez Schrempp, K. Hautzinger, B. Girard, K. Slobod, R. McPhee, R. Pajon, R. Das, Jacqueline M. Miller, S. Schnyder Ghamloush   +27 more
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Low-dose mRNA-1273 COVID-19 vaccine generates durable memory enhanced by cross-reactive T cells

Science, 2021
Description A smaller-dose jab does the job Low-dose messenger RNA (mRNA) vaccines potentially allow health providers to administer more doses from a limited vaccine supply and can be less reactogenic.
J. Mateus, J. Dan, Zeli Zhang, C. Rydyznski Moderbacher, M. Lammers, B. Goodwin, A. Sette, S. Crotty, D. Weiskopf   +8 more
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Serological response after COVID-19 mRNA-1273 booster dose in immunocompromised patients, Taiwan, July to August 2021

Journal of the Formosan Medical Association, 2022
Background: Whether immunocompromising conditions affect the immunogenicity of COVID-19 booster vaccination remains a concern, which impedes the vaccination campaign in people most vulnerable to COVID-19-associated morbidity and mortality.
Kuan-Yin Lin, Ming-Ju Hsieh, Sui-Yuan Chang, Si-Man Ieong, Chien-Yu Cheng, Wang-Huei Sheng, Shan-Chwen Chang   +6 more
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SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness [PDF]

, 2020
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic.
Abiona, O.M., Altaras, N.E., Alvarado, G.S., Bahl, K., Baric, R.S., Bennett, H., Bock, K.W., Boyoglu-Barnum, S., Carfi, A., Chang, L.A., Chappell, J.D., Corbett, K.S., Denison, M.R., Dinnon, K.H., DiPiazza, A.T., Doria-Rose, N.A., Edwards, D.K., Elbashir, S.M., Fritch, E.J., Garcia-Dominguez, D., Gillespie, R.A., Graham, B.S., Gully, K.L., Henry, C., Himansu, S., Hutchinson, G.B., Kong, W.-P., Leist, S.R., Leung, K., Liu, C., Loomis, R.J., Louder, M.K., Ma, L.Z., Martinez, D.R., Mascola, J.R., McLellan, J.S., Metkar, M., Minai, M., Moore, I.N., Morabito, K.M., Nagata, B.M., Narayanan, E., Nason, M.C., Phung, E., Presnyak, V., Renzi, I., Ruckwardt, T.J., Schmidt, S.D., Schäfer, A., Shaw, C.A., Shi, W., Stevens, L.J., Stewart-Jones, G., Wang, L., Wang, N., West, A., Woods, A., Wrapp, D., Wu, K., Yang, E.S., Zhang, Y., Ziwawo, C.T.   +61 more
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Adverse Effects of Third-Dose Moderna Vaccination for Healthcare Workers of Udayana University Hospital, Bali, Indonesia [PDF]

, 2022
. Background Since its first sighting in China at the end of 2019, COVID-19 had spread rapidly around the world, with no exception, to Indonesia. World Health Organization officially declared COVID-19 as a pandemic in March 2020.
Cokorda Agung Wahyu Purnamasidhi, Darren Junior, Dewa Ayu Fony Prema Shanti, Giovanca Verentzia Purnama, I Gede Purna Weisnawa, I Komang Hotra Adiputra, Jerry, Putu Kintan Wulandari, Richard Christian Suteja   +8 more
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mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

Cell, 2022
SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-matched vaccines would enhance protection.
M. Gagne, Juan I. Moliva, K. Foulds, Shayne F. Andrew, Barbara Flynn, Anne P. Werner, Danielle A. Wagner, I-Ting Teng, Bob C. Lin, Christopher Moore, Nazaire Jean-Baptiste, R. Carroll, S. Foster, M. Patel, Madison Ellis, V. Edara, Nahara Vargas Maldonado, Mahnaz Minai, L. McCormick, C. Honeycutt, Bianca M. Nagata, Kevin W. Bock, Caitlyn N. M. Dulan, Jamilet Cordon, Dillon R. Flebbe, J. Todd, Elizabeth McCarthy, Laurent Pessaint, Alex Van Ry, Brandon Narvaez, Daniel Valentin, Anthony Cook, A. Dodson, Katelyn Steingrebe, S. Nurmukhambetova, Sucheta Godbole, Amy R. Henry, Farida Laboune, Jesmine Roberts-Torres, C. Lorang, Shivani Amin, Jessica F. Trost, Mursal Naisan, Manjula Basappa, J. Willis, Lingshu Wang, W. Shi, N. Doria-Rose, Yi Zhang, E. Yang, K. Leung, S. O'Dell, S. Schmidt, A. Olia, Cuiping Liu, Darcy R. Harris, G. Chuang, Guillaume B. E. Stewart-Jones, Isabella Renzi, Y. Lai, A. Malinowski, Kai Wu, J. Mascola, A. Carfi, P. Kwong, D. Edwards, M. Lewis, H. Andersen, Kizzmekia S. Corbett, M. Nason, A. McDermott, M. Suthar, Ian N. Moore, M. Roederer, N. Sullivan, D. Douek, R. Seder   +76 more
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Analysis of the adverse events following the mRNA-1273 COVID-19 vaccine [PDF]

, 2023
OBJECTIVE: This study aims to characterize the adverse events (AEs) following the administration of the mRNA-1273 COVID-19 vaccine from the Vaccine Adverse Event Reporting System (VAERS) data.METHODS: In this case/non-case analysis, reports between 1 ...
Nishtala, Prasad S, Shabu, Angel
core   +1 more source

Effectiveness of mRNA-1273 vaccination against SARS-CoV-2 omicron subvariants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5

Nature Communications, 2023
In this study, the authors estimate the effectiveness of the mRNA-1273 (Moderna) vaccine for Omicron subvariants using data from the USA on ~31,000 cases and ~92,000 matched controls.
H. Tseng, B. Ackerson, K. Bruxvoort, L. Sy, J. Tubert, Gina S. Lee, J. Ku, A. Florea, Yi Luo, S. Qiu, S. Choi, H. Takhar, Michael Aragones, Y. Paila, S. Chavers, C. Talarico, L. Qian   +16 more
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Safety, immunogenicity, and reactogenicity of BNT162b2 and mRNA-1273 COVID-19 vaccines given as fourth-dose boosters following two doses of ChAdOx1 nCoV-19 or BNT162b2 and a third dose of BNT162b2 (COV-BOOST): a multicentre, blinded, phase 2, randomised trial.

Lancet. Infectious Diseases (Print), 2022
BACKGROUND Some high-income countries have deployed fourth doses of COVID-19 vaccines, but the clinical need, effectiveness, timing, and dose of a fourth dose remain uncertain.
A. Munro, S. Feng, L. Janani, V. Cornelius, P. Aley, G. Babbage, D. Baxter, M. Bula, K. Cathie, Krishna Chatterjee, Kate Dodd, Yvanne Enever, Ehsaan Qureshi, A. Goodman, C. Green, Linda Harndahl, J. Haughney, A. Hicks, Agatha A. van der Klaauw, Nasir Kanji, V. Libri, M. Llewelyn, A. McGregor, Mina H. Maallah, A. Minassian, P. Moore, M. Mughal, Y. Mujadidi, K. Holliday, O. Osanlou, R. Osanlou, Daniel R Owens, Mihaela Pacurar, A. Palfreeman, D. Pan, T. Rampling, K. Regan, Stephen Saich, Tanveer Bawa, D. Saralaya, S. Sharma, Ray Sheridan, E. Thomson, Shirley Todd, C. Twelves, R. Read, S. Charlton, B. Hallis, M. Ramsay, N. Andrews, T. Lambe, J. Nguyen-Van-Tam, M. Snape, Xinxue Liu, S. Faust, A. Riordan, A. Ustianowski, Chris A Rogers, K. Katechia, A. Cooper, A. Freedman, Rachel Hughes, L. Grundy, Lona Tudor Jones, Elizabeth Harrison, Emma Snashall, L. Mallon, Katharine Burton, K. Storton, Malathi Munusamy, B. Tandy, Akamino Egbo, S. Cox, N. Ahmed, Anil Shenoy, R. Bousfield, D. Wixted, H. Gutteridge, B. Mansfield, Christopher Herbert, J. Murira, J. Calderwood, D. Barker, J. Brandon, H. Tulloch, Suzie Colquhoun, H. Thorp, H. Radford, Julie Evans, H. Baker, J. Thorpe, S. Batham, J. Hailstone, R. Phillips, Dileep Kumar, F. Westwell, A. Sturdy, Lara Barcella, N. Soussi, Mushiya Mpelembue, S. Raj, Rajni Sharma, T. Corrah, L. John, A. Whittington, S. Roche, L. Wagstaff, A. Farrier, K. Bisnauthsing, Movin Abeywickrama, N. Spence, A. Packham, T. Serafimova, Suahil Aslam, Caitlin McGreevy, A. Borca, Pamela DeLosSantosDominguez, Emily Palmer, S. Broadhead, S. Farooqi, Joshua M. Piper, Rowena Weighell, L. Pickup, Djamila Shamtally, Jason Domingo, Evgenia Kourampa, C. Hale, J. Gibney, Michael Stackpoole, Zalina Rashid-Gardner, R. Lyon, Chloe McDonnell, C. Cole, A. Stewart, G. Mcmillan, Mary Savage, H. Beckett, Chantelle Moorbey, A. Desai, Claire Brown, Kush Naker, K. Gokani, Charlotte Trinham, Charlette Sabine, Sophie Moore, Steve Hurdover, E. Justice, M. Stone, E. Plested, Carla Ferreira da Silva, Rachel White, H. Robinson, I. Turnbull, Gertraud Morshead, R. Drake-Brockman, C. Smith, Grace Li, Mwila Kasanyinga, E. Clutterbuck, S. Bibi, Michael Singh, Trishna Champaneri, Margaret Irwin, Mohammed Khan, Alicia Kownacka, Martha Nabunjo, C. Osuji, John Hladkiwskyj, D. Galvin, Gitaben K Patel, J. Grierson, Samantha Males, Krishna Askoolam, Joshua Barry, J. Mouland, B. Longhurst, M. Moon, Beth Giddins, C. Pereira Dias Alves, L. Richmond, C. Minnis, S. Baryschpolec, S. Elliott, L. Fox, Victoria A. Graham, Natalie Baker, K. Godwin, K. Buttigieg, Chanice Knight, Phillip J. Brown, Paminder Lall, Imam Shaik, Emily Chiplin, Emily Brunt, Stephanie Leung, Lauren Allen, Steve Thomas, Sara Fraser, Bea Choi, Jade Gouriet, J. Perkins, Andrew Gowland, J. Macdonald, J. Seenan, Igor Starinskij, A. Seaton, E. Peters, S. Singh, Ben Gardside, Avril Bonnaud, Ceri Davies, Elizabeth Gordon, S. Keenan, Jane Hall, S. Wilkins, S. Tasker, R. James, Ingrid Seath, Kelly Littlewood, J. Newman, I. Boubriak, Debbie Suggitt, Helen Haydock, S. Bennett, W. Woodyatt, K. Hughes, Judith Bell, Tricia Coughlan, Donald van Welsenes, M. Kamal, Chris Cooper, Simon Tunstall, Nicholas Ronan, R. Cutts, T. Dare, Y. T. N. Yim, Sarah Whittley, Shama Hamal, Marivic Ricamara, Kirsty Adams, Holly Baker, Kimberley Driver, N. Turner, T. Rawlins, Subarna Roy, Marta Merida-Morillas, Yukari Sakagami, Antonette Andrews, Lillian Goncalvescordeiro, Matthew Stokes, W. Ambihapathy, Joanne Spencer, Nina Parungao, L. Berry, James Cullinane, L. Presland, Amy L Ross Russell, Sarah C. Warren, Jonathan Baker, A. Oliver, A. Buadi, Kim Lee, L. Haskell, R. Romani, I. Bentley, Tim Whitbred, S. Fowler, John T. Gavin, Alan Magee, Tara Watson, Kari Nightingale, P. Marius, Eloise Summerton, Emily Locke, ThomasJack Honey, Aidan Lingwood, Anastasia de la Haye, R. S. Elliott, Karen Underwood, M. King, Sharon Davies-Dear, E. Horsfall, Olivia Chalwin, H. Burton, C. Edwards, B. Welham, Kim Appleby, Emily J Dineen, Sarah Garrahy, F. Hall, Eleni Ladikou, D. Mullan, D. Hansen, Marion Campbell, Filipa Dos Santos, N. Lakeman, D. Branney, L. Vamplew, A. Hogan, J. Frankham, M. Wiselka, D. Vail, V. Wenn, V. Renals, K. Ellis, Jessica Lewis-Taylor, Haniah Habash-Bailey, J. Magan, Anna C. Hardy   +308 more
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Safety outcomes associated with the moderna COVID-19 vaccine (mRNA-1273): a literature review

Expert Review of Vaccines, 2023
Introduction Current safety data from Phase 3 clinical trials have concluded that apart from transient local and systemic reactions, no safety concerns were identified for the Moderna COVID-19 vaccine (mRNA-1273).
Angel Shabu, Prasad S. Nishtala
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