Results 131 to 140 of about 3,391,200 (390)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
The Stargazin-Related Protein {gamma}7 Interacts with the mRNA-Binding Protein Heterogeneous Nuclear Ribonucleoprotein A2 and Regulates the Stability of Specific mRNAs, Including CaV2.2 [PDF]
, 2008 The role(s) of the novel stargazin-like {gamma}-subunit proteins remain controversial. We have shown previously that the neuron-specific {gamma}7 suppresses the expression of certain calcium channels, particularly CaV2.2, and is therefore unlikely to ...
Bolsover, Steven +11 more
core +1 more source
Selection of suitable reference genes for real-time PCR studies of early developmental stages of sturgeons [PDF]
بومشناسی آبزیان, 2013 In quantitative real-time PCR, the mRNA level can be quantified in relative terms based on the expression ratio of mRNAs of the target gene and an internal reference gene.
Arash Akbarzadeh +5 more
doaj
Molecular Oncology, EarlyView.Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan +10 more
wiley +1 more source
Active role of elongation factor G in maintaining the mRNA reading frame during translation. [PDF]
, 2019 During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not ...
Belardinelli, R. +5 more
core +2 more sources
Romanian Journal of Oral Rehabilitation, 2023 Periodontal disease is considered to be connected with some very well-known anaerobic etiological agents. Many studies are analysing the associations between Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Tannerella forsythia with ...
Oana Bejan +9 more
doaj
The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Many studies have highlighted the importance of the tight regulation of mRNA stability in the control of gene expression. mRNA stability largely depends on the mRNA nucleotide sequence, which affects the secondary and tertiary structures of the mRNAs ...
Sung Ho Boo, Yoon Ki Kim
semanticscholar +1 more source
A career in (mRNA) decay [PDF]
RNA, 2015 My entry into the RNA world began in 1967 when a visiting lecturer at the University of Toronto, the late Dr. Gordon Tener, inspired my interest in RNA. Various aspects of RNA biology, from ribosomes to plant viruses, occupied my attention during the early stages of my career.
openaire +3 more sources
Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma
Molecular Oncology, EarlyView.This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu +15 more
wiley +1 more source
A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. [PDF]
, 2017 mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown
Ding, Junjun +14 more
core +1 more source