Results 131 to 140 of about 3,421,970 (401)

Degradation of mRNA in eukaryotes

Cell, 1995
Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation mechanisms specific to individual ...
Roy Parker, Roy Parker, Clare A. Beelman
openaire   +3 more sources

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Single-cell mRNA quantification and differential analysis with Census

Nature Methods, 2017
Single-cell gene expression studies promise to reveal rare cell types and cryptic states, but the high variability of single-cell RNA-seq measurements frustrates efforts to assay transcriptional differences between cells.
Xiaojie Qiu, Andrew J. Hill, Jonathan S. Packer, Dejun Lin, Yian Ma, Yian Ma, C. Trapnell   +6 more
semanticscholar   +1 more source

Ionizable Lipid Nanoparticle Mediated mRNA Delivery for Human CAR T Cell Engineering.

Nano letters (Print), 2020
CAR T cell therapy relies on the ex vivo manipulation of patient T cells to create a potent, cancer-targeting therapy, shown to be capable of inducing remission in patients with acute lymphoblastic leukemia and large B cell lymphoma. However, current CAR
Margaret M. Billingsley, Nathan Singh, Pranali Ravikumar, Rui Zhang, C. June, M. J. Mitchell   +5 more
semanticscholar   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Pharmaceutics, 2020
In the past few years, there has been increasing focus on the use of messenger RNA (mRNA) as a new therapeutic modality. Current clinical efforts encompassing mRNA-based drugs are directed toward infectious disease vaccines, cancer immunotherapies ...
Abishek Wadhwa, Anas Aljabbari, A. Lokras, C. Foged, Aneesh Thakur   +4 more
semanticscholar   +1 more source

Mechanisms of mRNA polyadenylation

TURKISH JOURNAL OF BIOLOGY, 2016
mRNA 3'-end processing involves the addition of a poly(A) tail based on the recognition of the poly(A) signal and subsequent cleavage of the mRNA at the poly(A) site. Alternative polyadenylation (APA) is emerging as a novel mechanism of gene expression regulation in normal and in disease states.
Agus, Hizlan Hincal, Bensan, Ayse Elif Erson   +1 more
openaire   +4 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The mRNA expression profile of genes of innate immune receptors in the pathogenesis of atherosclerosis

Атеросклероз, 2015
The article covers the relevance of studying mRNA expression profile of genes of innate immune receptors, in particular genes of TLRs. The ability of TLRs to express at the surface of various cells, even at those that do not belong to the innate and ...
V. A. Ipatova, A. V. Ponasenko
doaj  

An ensemble method to predict target genes and pathways in uveal melanoma

Open Life Sciences, 2018
This work proposes to predict target genes and pathways for uveal melanoma (UM) based on an ensemble method and pathway analyses. Methods: The ensemble method integrated a correlation method (Pearson correlation coefficient, PCC), a causal inference ...
Wei Chao, Wang Lei, Zhang Han
doaj   +1 more source