Results 131 to 140 of about 2,344,135 (339)
Acta Medica Bulgarica, 2020 Background and objectives. Though numerous studies have shown that the dysregulation of the epigenetic control is involved in disease manifestation, limited data is available on the transcriptional activity of DNA methylation related genes in alcohol and
Krasteva M. +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
CHEMOKINES AND THEIR RECEPTORS EXPRESSION IN BLOOD AND LIVER TISSUE IN CHRONIC HEPATITIS C
Медицинская иммунология, 2014 . Chronic hepatitis C (CHC) is widely spread disease with a long incubation period and weakle expressed clinical features. Pathogenesis of CHC despite of intensive efforts is still unclear.
K. V. Zhdanov +6 more
doaj +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
EXPRESSION OF AID-SPECIFIC mRNA IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
Медицинская иммунология, 2015 The aim of this study was to evaluate a possible role of AID (AICDA – activation-induced (cytidine) deaminase) in the bronchial asthma (BA) pathogenesis. Materials and methods.
V. N. Mineev +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cancer stem cells are associated with aggressive disease, but a deep characterization of such markers is lacking in endometrial cancer. This study uses imaging mass cytometry to explore putative cancer stem cell markers in endometrial tumors and corresponding organoid models.
Hilde E. Lien +7 more
wiley +1 more source
Translational NeuroscienceForkhead box P3 (FOXP3) plays a critical role in the pathogenesis of autoimmune disorders. In the present study, we genotyped three single-nucleotide polymorphisms, namely, rs2232365, rs3761548, and rs3761549, to determine the relationship between FOXP3 ...
Liu Jing +5 more
doaj +1 more source
Биопрепараты: Профилактика, диагностика, лечение, 2019 This review focuses on DNA and RNA vaccines whose potential use was first considered at the end of the 20th century. However, not a single bacterial plasmid-based or mRNA vaccine has been used since that time in public healthcare for the prevention of ...
A. A. Goryaev +4 more
doaj +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source