Results 371 to 380 of about 3,391,200 (390)
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Detection of Uridylated mRNAs

2014
Uridine addition at the 3' end of RNAs (i.e., uridylation) emerges as a critical posttranscriptional modification promoting RNA degradation. Uridylation has been notably linked to the degradation of small RNAs, correlated with the 5' shortening of RISC-cleaved transcripts and the degradation of mRNAs.
François M. Sement, Dominique Gagliardi
openaire   +4 more sources

mRNA-based cancer therapeutics

Nature Reviews. Cancer, 2023
Chuang Liu   +5 more
semanticscholar   +1 more source

CYP3A5 mRNA Degradation by Nonsense-Mediated mRNA Decay

Molecular Pharmacology, 2005
The total CYP3A5 mRNA level is significantly greater in carriers of the CYP3A5*1 allele than in CYP3A5*3 homozygotes. Most of the CYP3A5*3 mRNA includes an intronic sequence (exon 3B) containing premature termination codons (PTCs) between exons 3 and 4.
Florent Busi, Thierry Cresteil
openaire   +3 more sources

The cytoskeleton and mRNA localization

Current Opinion in Cell Biology, 1992
The localization of mRNA appears to facilitate protein sorting, so that proteins are synthesized in specific cellular regions. The spatial information on the mRNA may be transduced by proteins that recognize specific localizing sequences on the 3' end and then chaperone the mRNA, presumably along filaments, to its destination. Additional sequences such
openaire   +3 more sources

Shutdown decay of mRNA

Molecular Microbiology, 2006
SummaryAlthough plasmid‐borne and chromosomal toxin–antitoxin (TA) operons have been known for some time, the recent identification of mRNA as the target of at least two different classes of toxins has led to a dramatic renewal of interest in these systems as mediators of stress responses.
openaire   +4 more sources

mRNA vaccines

Nature Biotechnology, 2021
openaire   +2 more sources

Reading, writing and erasing mRNA methylation

Nature reviews. Molecular cell biology, 2019
S. Zaccara, R. Ries, S. Jaffrey
semanticscholar   +1 more source

Initiation Factor/mRNA Interactions and mRNA Recognition

1982
The recognition of mRNA and its binding to ribosomes are generally considered to be of key importance to translational control. That is, the decision whether a given mRNA species will be translated during cell growth, differentiation or virus infection is largely determined at initiation.
openaire   +2 more sources

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