Results 131 to 140 of about 1,826,338 (237)

UPF1/SMG7-dependent microRNA-mediated gene regulation

Nature Communications, 2019
UPF1 mediates the decay of target mRNA in a 3′ untranslated region (UTR)-length-dependent manner. Here the authors reveal that the 3′UTR-length-dependent regulation of UPF1-dependent mRNA decay occurs through EJC-independent but miRNA-dependent ...
Jungyun Park, Jwa-Won Seo, Narae Ahn, Seokju Park, Jungwook Hwang, Jin-Wu Nam   +5 more
doaj   +1 more source

mRNA turnover rate limits siRNA and microRNA efficacy

Molecular Systems Biology, 2010
The microRNA pathway participates in basic cellular processes and its discovery has enabled the development of si/shRNAs as powerful investigational tools and potential therapeutics. Based on a simple kinetic model of the mRNA life cycle, we hypothesized
Erik Larsson, Chris Sander, Debora Marks
doaj   +1 more source

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]

, 2019
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Aplin, Andrew E., Cui, Yan-Hong, Deng, Yu, He, Chuan, He, Yu-Ying, Hwang, Seungmin, Lu, Zhike, Park, Gayoung, Shah, Palak, Wei, Jiangbo, Yang, Seungwon   +10 more
core   +1 more source

Mathematical and computational modelling of post-transcriptional gene relation by micro-RNA [PDF]

, 2009
Mathematical models and computational simulations have proved valuable in many areas of cell biology, including gene regulatory networks. When properly calibrated against experimental data, kinetic models can be used to describe how the concentrations of
Higham, Desmond J., Khanin, Raya
core   +1 more source

A rapid inducible RNA decay system reveals fast mRNA decay in P-bodies

Nature Communications
RNA decay is vital for regulating mRNA abundance and gene expression. Existing technologies lack the spatiotemporal precision or transcript specificity to capture the stochastic and transient decay process.
Lauren A. Blake, Leslie Watkins, Yang Liu, Takanari Inoue, Bin Wu   +4 more
doaj   +1 more source

PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation

Cell & Bioscience
Background Oocyte maturation defect (OMD) and early embryonic arrest result in female infertility. Previous studies have linked biallelic mutations in the PATL2 gene to OMD, yet the underlying mechanism remains largely unknown.
Yin-Li Zhang, Zhanhong Hu, Huifang Jiang, Jiamin Jin, Yan Zhou, Mengru Lai, Peipei Ren, Siya Liu, Ying-Yi Zhang, Yan Rong, Wei Zheng, Shen Zhang, Xiaomei Tong, Songying Zhang   +13 more
doaj   +1 more source

Nonsense-mediated mRNA decay [PDF]

Current Biology, 2002
openaire   +2 more sources

Arabidopsis mRNA decay landscape arises from specialized RNA decay substrates, decapping-mediated feedback, and redundancy

Proceedings of the National Academy of Sciences of the United States of America, 2018
Reed S. Sorenson, Malia J. Deshotel, Katrina Johnson, F. Adler, L. Sieburth   +4 more
semanticscholar   +1 more source

SnapShot: Nonsense-Mediated mRNA Decay

Cell, 2011
Durand, Sébastien, Lykke-Andersen, Jens
openaire   +2 more sources

5PSeq Explorer: interactive analysis of co-translational mRNA decay and ribosome dynamics. [PDF]

RNA Biol
Stevens I, Pelechano V.
europepmc   +1 more source