Results 241 to 250 of about 881,660 (270)
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Science, 2001
There seem to be numerous pathways for exporting mRNAs from the nucleus to the cytoplasm. But working out which set of export adaptors and receptors transport individual mRNAs has been very difficult. In a Perspective, [Moore and Rosbash][1] discuss a new strategy using cell-penetrating peptide inhibitors for unraveling the routes of mRNA export in ...
Melissa J. Moore, Michael Rosbash
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There seem to be numerous pathways for exporting mRNAs from the nucleus to the cytoplasm. But working out which set of export adaptors and receptors transport individual mRNAs has been very difficult. In a Perspective, [Moore and Rosbash][1] discuss a new strategy using cell-penetrating peptide inhibitors for unraveling the routes of mRNA export in ...
Melissa J. Moore, Michael Rosbash
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Nature Cell Biology, 2006
Precise spatial regulation of mRNA remodelling is crucial for proper gene expression. One way this is accomplished is through activation of the DEAD-box helicase Dbp5 at the cytoplasmic fibrils of the nuclear-pore complex, by the nucleoporin Gle1 and the soluble inositol polyphosphate InsP6.
Charles N. Cole, John J. Scarcelli
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Precise spatial regulation of mRNA remodelling is crucial for proper gene expression. One way this is accomplished is through activation of the DEAD-box helicase Dbp5 at the cytoplasmic fibrils of the nuclear-pore complex, by the nucleoporin Gle1 and the soluble inositol polyphosphate InsP6.
Charles N. Cole, John J. Scarcelli
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Pre-mRNA processing and mRNA nuclear export
Current Opinion in Cell Biology, 1989The primary transcript of a prokaryotic gene is translated immediately following or during synthesis, whereas in eukaryotes, messenger RNA (mRNA) precursors (premRNAs) are synthesized in the nucleus and are then structurally altered and relocated to the cytoplasm before translation (Fig. 1).
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Structure and function of mRNA export adaptors
Biochemical Society Transactions, 2010The mRNA export adaptors provide an important link between multiple nuclear mRNA processing events and the mRNA export receptor TAP/NXF1/Mex67p. They are recruited to mRNA through transcriptional and post-transcriptional events, integrating this information to licence mRNA for export.
Matthew J, Walsh +2 more
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TREX, SR proteins and export of mRNA
Current Opinion in Cell Biology, 2005The machineries involved in gene expression are highly conserved from yeast to metazoans. However, a fundamental difference between these organisms is that most yeast genes lack introns whereas the converse is true in higher organisms. Recent studies of the TREX complex, which functions in mRNA export, unexpectedly revealed that this complex is ...
Robin, Reed, Hong, Cheng
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Nature Structural & Molecular Biology, 2004
A recent study on the RNA-binding protein Npl3p reveals how its direct interaction with the mRNA export receptor Mex67p is regulated by phosphorylation and how this post-translational modification contributes to the assembly and disassembly of mRNP export complexes.
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A recent study on the RNA-binding protein Npl3p reveals how its direct interaction with the mRNA export receptor Mex67p is regulated by phosphorylation and how this post-translational modification contributes to the assembly and disassembly of mRNP export complexes.
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Nature Genetics, 2003
A new study shows that cellular mRNAs can be organized and exported from the nucleus as functionally related groups by RNA-binding proteins, possibly corresponding to specific gene-expression networks activated by transcription factors. The combinatorial assortment of mRNAs as functional subsets has the potential to generate a variety of complex ...
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A new study shows that cellular mRNAs can be organized and exported from the nucleus as functionally related groups by RNA-binding proteins, possibly corresponding to specific gene-expression networks activated by transcription factors. The combinatorial assortment of mRNAs as functional subsets has the potential to generate a variety of complex ...
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Coupling transcription, splicing and mRNA export
Current Opinion in Cell Biology, 2003Previous studies have led to the view that mRNAs are transported from the nucleus to the cytoplasm by machinery that is conserved from yeast to humans. Moreover, this machinery is coupled both physically and functionally to the pre-mRNA splicing machinery.
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The mRNA export pathway in plants
Frontiers in Biology, 2011A double lipid bilayer separating the nucleus from the cytoplasm, termed the nuclear envelope, is a defining feature of eukaryotes. Nucleocytoplasmic transport of macromolecules through the nuclear pores enables fine-tuned regulation of biologic processes. All mature mRNAs are delivered to the cytoplasm from the nucleus via an mRNA export pathway. Much
Oliver X. Dong +3 more
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HnRNP proteins and the nuclear export of mRNA
Seminars in Cell & Developmental Biology, 1997Pre-mRNAs associate in the nucleus with specific RNA-binding proteins to form heterogeneous nuclear ribonucleoprotein (hnRNP) complexes. The hnRNP proteins participate directly or indirectly in the processing of pre-mRNAs into mature mRNAs. Recent studies have shown that some hnRNP proteins shuttle continuously between the nucleus and the cytoplasm ...
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