Results 261 to 270 of about 664,318 (297)

Unsupervised clustering in mRNA expression profiles

Computers in Biology and Medicine, 2006
The development of microarray technologies gives scientists the ability to examine, discover and monitor the mRNA transcript levels of thousands of genes in a single experiment. Nonetheless, the tremendous amount of data that can be obtained from microarray studies presents a challenge for data analysis.
D K, Tasoulis, V P, Plagianakos, M N, Vrahatis   +2 more
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Overview of mRNA Expression Profiling Using DNA Microarrays

Current Protocols in Molecular Biology, 2009
AbstractDNA microarray technology allows simultaneous measurement of the mRNA levels of thousands of genes. This powerful technology has applications in addressing many biological questions that were not approachable previously; however, the enormous size of microarray data sets leads to issues of experimental design and statistical analysis that are ...
Fumiaki, Katagiri, Jane, Glazebrook
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mRNA expression profile of mouse oligodendrocytes in inflammatory conditions

Doklady Biochemistry and Biophysics, 2016
In this study, we performed transcriptome profiling of oligodendrocyte culture of mice treated with the remyelinating therapeutic agent benztropine in the presence and absence of interferon gamma (IFNγ). The results of this work are important for understanding the expression profile of oligodendrocytes under conditions of systemic inflammation in the ...
Kudriaeva A., Khaustova N., Maltseva D., Kuzina E., Glagoleva I., Surina E., Knorre V., Belogurov A., Tonevitsky A., Gabibov A.   +9 more
openaire   +4 more sources

Profile of Cytokine mRNA Expression in Chronic Adult Periodontitis

Journal of Dental Research, 1997
Chronic inflammation induced by bacteria often leads to host-mediated destruction of tissues adjacent to the sites of microbial insult. The chronic inflammatory process of adult periodontitis results in the destruction of supporting osseous and connective tissues of the teeth.
F A, Roberts, K A, McCaffery, S M, Michalek   +2 more
openaire   +2 more sources

Microarray mRNA Expression Profiling to Study Cystic Fibrosis

2011
To understand the links between CFTR mutations and the development of cystic fibrosis (CF) phenotypes, it is imperative to study the transcriptome in affected cell types. Microarray expression profiling provides a platform to study global gene expression in detail.
Shyam, Ramachandran, Luka A, Clarke, Todd E, Scheetz, Margarida D, Amaral, Paul B, McCray   +4 more
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Identification of potential biomarkers for SLE through mRNA expression profiling

Journal of Immunoassay and Immunochemistry, 2023
Systemic lupus erythematosus (SLE) is an autoimmune disease that influences numerous body systems. Furin, tristetraprolin (TTP), and NOD, LRR, and pyrin domain-containing protein 3 (NLRP3) contribute in developing autoimmune illnesses.Understandthe role of furin, TTP, and NLRP3 mRNA gene expression in SLE pathogenesis and prognosis.
Sara Kamal Rizk, Amal Alhosary, Enas S. Zahran, Samah Awad, Marwa Khalil   +4 more
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Hydroxyapatite Modulates mRNA Expression Profiles in Cultured Osteocytes

Cellular and Molecular Bioengineering, 2012
Osteocytes in vivo present a unique pattern of gene expression necessary for bone remodeling and mineral metabolism. Genes expressed in osteocytes such as Sost and fibroblast growth factor 23 (FGF23) are essential for load-driven bone formation and regulation of phosphate in the serum, respectively.
Kazunori Hamamura, Liming Zhao, Chang Jiang, Nancy Tanjung, Gaurav Swarnkar, Hiroki Yokota   +5 more
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Tumor mRNA Expression Profiles Predict Responses to Chemotherapy

Journal of Clinical Oncology, 2007
The development of prognostic and diagnostic markers suchastumorstagingandmorerecentlymolecularfactorshavegreatlycontributed to identifying lung cancer patients that can benefitfrom adjuvant or neoadjuvant chemotherapy. However, the pre-dictingefficienciesvaryconsiderably,andmanytherapiesfailwhilesurviving patients often experience severe toxicities ...
John D. Minna, Luc Girard, Yang Xie
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Substrate stiffness modulates mRNA expression profiling in breast cancer cells

Clinical Hemorheology and Microcirculation, 2016
Identifying effective targets induced by ECM stiffness is of critical importance for treating metastatic cancer diseases, which are followed by changes in the mechanical microenvironment in cancer cells. In this study, polyacrylamide hydrogel substrates with different stiffnesses were prepared and mRNA microarrays were performed to analyze the mRNA ...
Cuiying, Liu, Xiang, Li, Jiantao, Feng, Fulong, Liao, Dongguo, Li, Dong, Han   +5 more
openaire   +2 more sources