Results 121 to 130 of about 19,056,956 (378)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

mRNA 3′end processing: A tale of the tail reaches the clinic

EMBO Molecular Medicine, 2013
Recent advances reveal mRNA 3′end processing as a highly regulated process that fine‐tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3′end processing, controlling the quality and the quantity of ...
Ina Hollerer, Kerstin Grund, Matthias W. Hentze, Andreas E Kulozik   +3 more
doaj   +1 more source

Identification of an Alternative Exon in a GABA Receptor Gene [PDF]

, 2018
The central dogma of biology states that DNA is transcribed into mRNA, which is then translated into proteins. In order for translation to occur, pre-mRNAs first must be processed.
Apgar, Shannon, Toro, Cecilia P.
core   +1 more source

Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries [PDF]

, 1993
The nuclear topography of splicing snRNPs, mRNA transcripts and chromosome domains in various mammalian cell types are described. The visualization of splicing snRNPs, defined by the Sm antigen, and coiled bodies, revealed distinctly different ...
A Monneron, A Schneider-G�dicke, AK Raap, B Roggenbuck, C Benyajati, C Collins, C Cremer, C Zorn, CA Ascoli, D Pinkel, D Pinkel, DE Comings, DJ Arndt-Jovin, DL Spector, DL Spector, DL Spector, DL Spector, DL Spector, DM Shotton, EA Lerner, G Blobel, GJ Brakenhoff, HTM Voort Van der, I Raska, J Bradl, JB Lawrence, JD Northway, JG Gall, JR Paulson, KC Carter, L Manuelidis, L Manuelidis, L Manuelidis, L Manuelidis, LEC Andrade, M Bachmann, M Bouteille, M Carmo-Fonseca, M Carmo-Fonseca, M Carmo-Fonseca, M Carmo-Fonseca, M Hochstrasser, M Mattioli, M Schardin, N Hutchison, P Lichter, P Lichter, P Lichter, P Lichter, R Berezney, R Reuter, R Verheijen, S Fakan, S Fakan, S Huang, SA Berman, T Cremer, T Cremer, TM Jovin, U Bond, U Nyman, Y Hiraoka, y Ramon, Y Xing, Y Xing   +64 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cyclosporin A-binding protein (cyclophilin) of Neurospora crassa [PDF]

, 1988
Cyclophilin (cyclosporin A-binding protein) has a dual localization in the mitochondria and in the cytosol of Neurospora crassa. The two forms are encoded by a single gene which is transcribed into mRNAs having different lengths and 5' termini ...
Hartl, Franz-Ulrich, Köhler, Helmut, Neupert, Walter, Nicholson, Donald W., Pfanner, Nikolaus, Tropschug, Maximilian, Wachter, Elmar   +6 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Ipa1 Is an RNA Polymerase II Elongation Factor that Facilitates Termination by Maintaining Levels of the Poly(A) Site Endonuclease Ysh1

Cell Reports, 2019
Summary: The yeast protein Ipa1 was recently discovered to interact with the Ysh1 endonuclease of the pre-mRNA cleavage and polyadenylation (C/P) machinery, and Ipa1 mutation impairs 3′end processing.
Erika L. Pearson, Joel H. Graber, Susan D. Lee, Kristoph S. Naggert, Claire L. Moore   +4 more
doaj   +1 more source

Infinite factorization of multiple non-parametric views [PDF]

, 2010
Combined analysis of multiple data sources has increasing application interest, in particular for distinguishing shared and source-specific aspects. We extend this rationale of classical canonical correlation analysis into a flexible, generative and non ...
A. Gelman, A. Klami, A. Klami, A. Rodriguez, A. Vinokourov, Arto Klami, C. Archambeau, C. Rasmussen, D. Blackwell, D. Blei, D. Cohn, D. Lee, D. M. Blei, D. M. Roy, G. Englebienne, I. Rivals, I. S. Dhillon, Janne Sinkkonen, K. Barnard, M. Welling, Mark Girolami, N. Friedman, N. L. Johnson, R. M. Neal, S. Becker, S. Rogers, Samuel Kaski, Simon Rogers, T. Hofmann, Y. W. Teh   +29 more
core   +2 more sources

Processing Endoribonucleases and mRNA Degradation in Bacteria [PDF]

Journal of Bacteriology, 2002
Volume 184, no. 17, p. 4645-4657, 2002. Page 4647, column 1, lines 42-45: The sentence should read “For example, one message in the T7 early polycistronic mRNA, as well as a few late messages, yields increased protein from RNase III cleavage while the others are not affected by such cleavages (41).”
openaire   +3 more sources