Results 151 to 160 of about 19,056,956 (378)
Attenuation in the rph‐pyrE operon of Escherichia coli and processing of the dicistronic mRNA [PDF]
, 1992 Jens T. Andersen +2 more
openalex +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Journal of Bacteriology“Pre-full-length” transcripts are produced at the end of the polycistronic galactose (gal) operon, 5′ galE-galT-galK-galM 3′, via Rho-dependent transcription termination (RDT) and -independent transcription termination.
Heung Jin Jeon +3 more
doaj +1 more source
The Expression and Regulation of Chemokines (CXCL9, CXCL10, CXCL11) in Urinary Bladder Inflammation of the Mouse [PDF]
, 2017 Interstitial cystitis is a serious chronic condition that causes bladder pain and increased voiding frequency in millions of adults in the US, most of them women.
Guo, Michael
core +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
3′-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors [PDF]
, 2013 Ivan Sabath +5 more
openalex +1 more source
Erythroid mRNA processing: a “splice of life”
Blood, 2014 Editing of primary gene transcripts to yield variant exon-included vs -excluded mRNA forms is an important mechanism for generating protein isoforms with diversified activities.2 To illustrate, one established hematologic example of such AS is FAS in which exon-6 inclusion yields a membrane-anchored proapoptotic ligand, whereas exon-6 excision ...
openaire +3 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source