Results 181 to 190 of about 18,476,439 (363)

The necessity of TbCNOT10 in the process of mRNA turnover

, 2012
Messenger RNA Degradierung startet mit Deadenylierung durch den CCR4-CAF1-NOT Komplex und darauf folgt entweder 5’ -> 3’ oder 3’ -> 5’ mRNA-Verdau. In dem protozoen Parasiten T. brucei wird die Genexpression hauptsachlich auf der Ebene des mRNA-Verdaus kontrolliert.
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

MAPP unravels frequent co-regulation of splicing and polyadenylation by RNA-binding proteins and their dysregulation in cancer

Nature Communications
Maturation of eukaryotic pre-mRNAs via splicing and polyadenylation is modulated across cell types and conditions by a variety of RNA-binding proteins (RBPs).
Maciej Bak, Erik van Nimwegen, Ian U. Kouzel, Tamer Gur, Ralf Schmidt, Mihaela Zavolan, Andreas J. Gruber   +6 more
doaj   +1 more source

Stem-loop structures control mRNA processing of the cellulosomal cip-cel operon in Ruminiclostridium cellulolyticum. [PDF]

Biotechnol Biofuels Bioprod, 2023
Wang N, Li P, Cheng Y, Song H, Xu C.
europepmc   +1 more source

ELAV mediates 3' UTR extension in the Drosophila nervous system

, 2012
Post-transcriptional gene regulation is prevalent in the nervous system, where multiple tiers of regulatory complexity contributeto the development and function of highly specialized cell types.
Hilgers, V., Lemke, S., Levine, M.
core   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

Pkhd1^cyli/cyli mice have altered renal Pkhd1 mRNA processing and hormonally sensitive liver disease. [PDF]

J Mol Med (Berl), 2023
Yang C, Harafuji N, Caldovic L, Yu W, Boddu R, Bhattacharya S, Barseghyan H, Gordish-Dressman H, Foreman O, Bebok Z, Eicher EM, Guay-Woodford LM.   +11 more
europepmc   +1 more source

Kinetics and Efficiency of Polyadenylation of Late Polyomavirus Nuclear RNA: Generation of Oligomeric Polyadenylated RNAs and Their Processing into mRNA [PDF]

, 1984
Nicholas H. Acheson
openalex   +1 more source

A single gene mutation predicts response to immune checkpoint blockade in ovarian clear cell carcinoma

Molecular Oncology, EarlyView.
Loss‐of‐function mutations in the scaffold subunit of protein phosphatase 2A (PP2A), PPP2R1A, sensitize ovarian clear cell carcinoma to immune checkpoint blockade (ICB) by enhancing the interferon gamma response and promoting antitumor immune cell infiltration.
Matheus Henrique Dias, René Bernards
wiley   +1 more source

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus. [PDF]

Nat Cell Biol, 2023
Navickas A, Asgharian H, Winkler J, Fish L, Garcia K, Markett D, Dodel M, Culbertson B, Miglani S, Joshi T, Yin K, Nguyen P, Zhang S, Stevers N, Hwang HW, Mardakheh F, Goga A, Goodarzi H.   +17 more
europepmc   +1 more source