Results 331 to 340 of about 18,476,439 (363)

Fluid Shear‐Controlled Pro/Anti‐Inflammatory Osteomodulatory Construct for Drug‐Free Immune Activation Through Cationic Ion Channel Activation

Advanced Healthcare Materials, EarlyView.
A 3D‐printed PCL scaffold coated with Arginine was laminated with electrospun polyvinyl alcohol (PVA) nanofibers containing cationic cellulose nanocrystals (PVA@cCNC). This created nanoisland‐like regions of aligned and random cCNC‐rich fibers. The composite scaffold, under fluid shear stimulation, modulated macrophage polarization from M1 to M2 ...
Keya Ganguly, Aayushi Randhawa, Sayan Deb Dutta, Jieun Lee, Youjin Seol, Mehran Mohammad Hossein Pour, Tejal V. Patil, Rumi Acharya, Ki‐Taek Lim   +8 more
wiley   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Targeting mRNA processing as an anticancer strategy [PDF]

Nature Reviews Drug Discovery, 2019
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations, alterations in mRNA can contribute to the initiation and progression of cancer.
Joana M. P. Desterro, Joana M. P. Desterro, Maria Carmo-Fonseca, Pedro Bak-Gordon   +3 more
openaire   +4 more sources

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Mutual relationships between transcription and pre‐mRNA processing in the synthesis of mRNA

WIREs RNA, 2012
AbstractThe generation of messenger RNA (mRNA) in eukaryotes is achieved by transcription from the DNA template and pre‐mRNA processing reactions of capping, splicing, and polyadenylation. Although RNA polymerase II (RNAPII) catalyzes the synthesis of pre‐mRNA, it also serves as a principal coordinator of the processing reactions in the course of ...
Tina Lenasi, Matjaz Barboric
openaire   +4 more sources

mRNA processing in the Trypanosomatidae

Experientia, 1991
Members of the Trypanosomatidae, which include the African trypanosomes, the American trypanosomes and the leishmanias, cause disease in vast proportions in man and his livestock and are a major detrimental factor to the social and economic well-being of the third world.
K. Perry, N. Agabian
openaire   +3 more sources

Processing and degradation of chloroplast mRNA

Biochimie, 2000
The conversion of genetic information stored in DNA into a protein product proceeds through the obligatory intermediate of messenger RNA. The steady-state level of an mRNA is determined by its relative synthesis and degradation rates, i.e., an interplay between transcriptional regulation and control of RNA stability.
Rita A Monde, David B. Stern, Gadi Schuster   +2 more
openaire   +3 more sources

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

Science Translational Medicine, 2019
Targeting parasitic endonuclease CPSF3 with an oxaborole offers a potent and selective candidate treatment against cryptosporidiosis. Controlling Cryptosporidium The apicomplexan parasite Cryptosporidium causes potentially life-threatening ...
C. Swale, Alexandre Bougdour, Audrey Gnahoui-David, Julie Tottey, S. Georgeault, F. Laurent, A. Palencia, Mohamed-Ali Hakimi   +7 more
semanticscholar   +1 more source

Control of mRNA processing and decay in prokaryotes

Genetica, 1994
Post-transcriptional mechanisms operate in regulation of gene expression in bacteria, the amount of a given gene product being also dependent on the inactivation rate of its own message. Moreover, segmental differences in mRNA stability of polycistronic transcripts may be responsible for differential expression of genes clustered in operons.
ALIFANO, Pietro, BRUNI CB, CARLOMAGNO MS
openaire   +5 more sources

Pre-mRNA processing and mRNA nuclear export

Current Opinion in Cell Biology, 1989
The primary transcript of a prokaryotic gene is translated immediately following or during synthesis, whereas in eukaryotes, messenger RNA (mRNA) precursors (premRNAs) are synthesized in the nucleus and are then structurally altered and relocated to the cytoplasm before translation (Fig. 1).
openaire   +3 more sources

mRNA Decay and Processing [PDF]

, 2014
Since there have been several extensive reviews of mRNA decay within the last several years, this chapter focuses on issues that have not been completely resolved. These include the importance of RNA structural elements in mRNA decay, the existence and function of multiprotein mRNA decay complexes, the role of polyadenylation in mRNA decay, the ...
openaire   +1 more source