Results 11 to 20 of about 117,359 (326)

Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria [PDF]

British Journal of Cancer, 2012
BACKGROUND: Overexpression of plasma membrane multi-drug resistance protein 1 (MRP-1) can lead to multidrug resistance. In this study, we describe for the first time the expression of mitochondrial MRP-1 in untreated human normal and cancer cells and ...
A Haimeur, A Rajagopal, A Zutz, AM Kaufmann, C Lhomme, CA Filippo, CD Hurst, CE Grant, DC Tomlinson, DW Loe, DW Loe, DW Zhang, E A Roundhill, E Munteanu, EJ Chapman, EP Neve, G Jedlitschky, G Westwood, I Leier, J Renes, KM Redmond, L Gandhi, L Zheng, M Cheon, M Kim, M Lastowska, M Solazzo, N Pfanner, NM Maraldi, O Legrand, P Jungsuwadee, P Ruff, R Zhou, RL Juliano, S A Burchill, S Zhou, SJ Ralph, SP Cole, SS Myatt, SS Myatt, T Rajkumar   +40 more
core   +2 more sources

Mrp Antiporters Have Important Roles in Diverse Bacteria and Archaea

Frontiers in Microbiology, 2017
Mrp (Multiple resistance and pH) antiporter was identified as a gene complementing an alkaline-sensitive mutant strain of alkaliphilic Bacillus halodurans C-125 in 1990.
Masahiro Ito, Masahiro Ito, Masato Morino, Masato Morino, Terry A. Krulwich   +4 more
doaj   +2 more sources

RNase MRP and disease

WIREs RNA, 2010
AbstractThe human RNase MRP complex consists of a catalytic RNA and several protein components. RNase MRP is a ubiquitously expressed eukaryotic endoribonuclease that cleaves various RNAs, including ribosomal, messenger, and mitochondrial RNAs, in a highly specific fashion.
Mattijssen, S., Welting, T.J.M., Pruijn, G.J.M., Pruijn, G.J.M.   +3 more
openaire   +4 more sources

Folic acid (FA)-conjugated mesoporous silica nanoparticles combined with MRP-1 siRNA improves the suppressive effects of myricetin on non-small cell lung cancer (NSCLC).

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Non-small cell lung cancer (NSCLC) is a common diagnosed cancer disease worldwide and its management remains a challenge. Synergistic cancer therapeutic strategy is interesting for multiple advantages, such as excellent targeting accuracy, low side ...
Yinxue Song, Bin Zhou, Xiangyang Du, Yong Wang, Jie Zhang, Yanqiu Ai, Zongjiang Xia, Gaofeng Zhao   +7 more
semanticscholar   +1 more source

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Structural insight into precursor ribosomal RNA processing by ribonuclease MRP

Science, 2020
Adapted to the task at hand RNA-based catalysts perform fundamental tasks in cellular RNA metabolism, especially in eukaryotes, where RNAs are cut by specialized ribonucleoproteins (RNPs) as part of ribosome assembly or messenger RNA regulation or ...
P. Lan, Bin Zhou, M. Tan, Shaobai Li, Mi Cao, Jian Wu, M. Lei   +6 more
semanticscholar   +1 more source

Cryo-EM structure of catalytic ribonucleoprotein complex RNase MRP

Nature Communications, 2020
RNase MRP is an essential eukaryotic ribonucleoprotein complex involved in the maturation of rRNA and the regulation of the cell cycle. RNase MRP is related to the ribozyme-based RNase P, but it has evolved to have distinct cellular roles.
A. Perederina, Di Li, Hyunwook Lee, C. Bator, I. Berezin, S. Hafenstein, A. S. Krasilnikov   +6 more
semanticscholar   +1 more source

FUNÇÕES E APLICAÇÕES DAS ATIVIDADES DO PLANEJAMENTO E CONTROLE DA PRODUÇÃO EM UMA INDÚSTRIA DE INSUMOS PARA EMPRESAS DO SETOR TÊXTIL DO CEARÁ

Revista Gestão em Análise, 2020
O objetivo deste estudo é analisar como as atividades do Planejamento e Controle da Produção (PCP) são realizadas na prática em uma empresa de insumos que atua no setor têxtil, observando a aplicação dos Sistemas de Coordenação de Ordens (SCOs), como o ...
Isaque Santiago Amaro Costa, Jorge dos Santos Gurgel, Andréa Moura da Costa Souza   +2 more
doaj   +1 more source

Protection of pigs against challenge with virulent Streptococcus suis serotype 2 strains by a muramidase-released protein and extracellular factor vaccine [PDF]

, 2001
The efficacy of a muramidase-released protein (MRP) and extracellular factor (EF) vaccine in preventing infection and disease in pigs challenged either with a homologous or a heterologous Streptococcus suis serotype 2 strain (MRP EF ) was compared with ...
Smith, H.E., Stockhofe Zurwieden, N., Vecht, U., Wisselink, H.J.   +3 more
core   +2 more sources

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex.

Molecules and Cells, 2019
N6-methyladenosine (m6A) is the most abundant internal modification in RNAs and plays regulatory roles in a variety of biological and physiological processes. Despite its important roles, the molecular mechanism underlying m6A-mediated gene regulation is
O. Park, Hongseok Ha, Yujin Lee, Sung Ho Boo, D. H. Kwon, H. Song, Yoon Ki Kim   +6 more
semanticscholar   +1 more source