Results 51 to 60 of about 21,996 (229)

Quantitative Systems Toxicology Model Predicts Obeticholic Acid‐Associated Liver Injury in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Clinical Pharmacology &Therapeutics, EarlyView.
Obeticholic acid (OCA), a synthetic analog of chenodeoxycholic acid, was approved in 2016 for the treatment of primary biliary cholangitis. Early clinical trials revealed elevated liver biomarkers in healthy subjects receiving supratherapeutic OCA doses (100–250 mg).
Abigail K. Mayo, James J. Beaudoin, Jeffrey L. Woodhead, Paul B. Watkins, Kim L. R. Brouwer   +4 more
wiley   +1 more source

Early and Larval Development of the Marine Species Grey Triggerfish (Balistes capriscus, Gmelin, 1789) and the Use of Different Organisms as First Food Sources

Aquaculture, Fish and Fisheries
The aim of this study was to provide an initial description of the embryology and larval development of Balistes capriscus species obtained from natural spawning in captivity. The study also aimed to assess the stocking density and the impact of offering
Henrique David Lavander, Mileni da Silva Pereira Gonçalves Lopes, Douglas da Cruz Mattos, Darlan Gonçalves Azevedo, Tiago Queiroz deMorais, Silvio Cesar Costa, Esaú Felipe Vial Laranjeira, Adriano Teixeira deOliveira, Paulo Henrique Rocha Aride, Leonardo Demier Cardoso   +9 more
doaj   +1 more source

Myeloid-Related Protein Activity in Rheumatoid Arthritis

International Journal of Inflammation, 2011
SA100A8, SA100A9, and SA100A12 are members of the myeloid-related protein class. SA100A8 and SA100A9, also known as MRP-8 and MRP-14, respectively, are intracellular Ca2+-binding proteins produced mainly by neutrophils and monocytes where they exist as a
Charles J. Malemud
doaj   +1 more source

Integrated assessment of rifampicin‐mediated induction of transporters and drug‐metabolizing enzymes in a long‐term human liver tissue chip system

Clinical Pharmacology &Therapeutics, EarlyView.
Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer, Raeanne M. Lanphier, Shivam Ohri, Jessica Snyder, Jacqueline B. Tiley, John K. Fallon, Henry Ho, Murat Cirit, Shiny Amala Priya Rajan, Kim L. R. Brouwer   +9 more
wiley   +1 more source

Approach to Implementation of Local Navigation of Mobile Robotic Systems in Agriculture with the Aid of Radio Modules

Telfor Journal, 2020
In this paper an approach is presented, enabling to solve the problem of local navigation of mobile robotic platforms (MRP), based on utilization of wireless networks with mesh topology. Establishment of wireless networks was ensured, based on the set of
R. Iakovlev, A. Saveliev
doaj   +1 more source

Magneto‐Electrochemical Effect on La‐Doped GaFeO3 as a Supercapacitor Electrode for Energy Storage

Electron, EarlyView.
The electrochemical performance of La‐doped Gallium Ferrite (La‐doped GaFeO3 ${\text{GaFeO}}_{3}$) synthesizes via a conventional solid‐state reaction method; this has been studied by the application of an external magnetic fields. ABSTRACT The electrochemical performance of La‐doped GaFeO3 ${\text{GaFeO}}_{3}$ synthesizes via a conventional solid ...
Biswajit Sahoo, Anuradha Yadav, Khusboo Agrawal, Piyush R. Das, Chandra Sekhar Rout, Banarji Behera   +5 more
wiley   +1 more source

El MRP En la gestión de inventarios

Revista Visión Gerencial, 2007
Los inventarios representan las existencias de recursos que las organizaciones usan para cumplir con sus objetivos. Para los países occidentales los inventarios son un problema mientras que para la cultura japonesa son caretas que intentan cubrir una ...
Carlos Enrique Bustos Flores, Galia Beatriz Chacón Parra   +1 more
doaj  

Interaction of Fibrinogen and Muramidase-released Protein Promotes the Development of Streptococcus suis Meningitis

Frontiers in Microbiology, 2015
Muramidase-released protein (MRP) is as an important virulence marker of Streptococcus suis (S. suis) serotype 2. Our previous works have shown that MRP can bind human fibrinogen (hFg); however, the function of this interaction in S.suis meningitis is ...
Junping eWang, Decong eKong, Shengwei eZhang, Hua eJiang, Yuling eZheng, Yating eZang, Huaijie eHao, Yongqiang eJiang   +7 more
doaj   +1 more source

518 myRESEARCHpath: an interactive roadmap for navigating research process, resources, and policies at Duke University

Journal of Clinical and Translational Science, 2022
OBJECTIVES/GOALS: In 2021, Duke University expanded the myRESEARCHsuite (MRS) of research support services with the launch of myRESEARCHpath (MRP), an interactive roadmap for navigating the project lifecycle. MRP integrates with the existing MRS services,
Jamie Wylie, Rebecca Brouwer, Derek Jones, Sunita Patil   +3 more
doaj   +1 more source

A multicenter analysis of 1364 elective/rescue cerclages in Brazil: Perinatal outcomes, complications, and the role of vaginal progesterone

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To evaluate perinatal outcomes in women undergoing cervical cerclage for prevention of preterm birth in Brazilian maternity hospitals. Methods This retrospective cohort study included 1364 women with singleton pregnancies who underwent elective or rescue cervical cerclage between December 2003 and November 2025.
Isabella C. Bragheto, Gabriela M. Pereira, Camila Mirandez, Marcelo Luis Nomura, Elton Carlos Ferreira, Rodolfo C. de Pacagnella, Evelyn Traina, Danilo B. Silva, Karayna Gil Fernandes, Julia Negro, Conrado M. Coutinho, Manuella R. Pereira, Janete Vettorazzi, Julia Hubner, Edson Vieira Cunha Filho, Ellen M. Arlindo, Aluana R. Parola, Pedro D. Correa, Renato Passini Junior, Renato T. Souza   +19 more
wiley   +1 more source