Results 1 to 10 of about 7,389 (203)

Dual role of cAMP in the transcriptional regulation of multidrug resistance-associated protein 4 (MRP4) in pancreatic adenocarcinoma cell lines. [PDF]

PLoS ONE, 2015
Cyclic AMP represents one of the most studied signaling molecules and its role in proliferation and differentiation processes has been well established. Intracellular cAMP levels are tightly regulated where the MRP4 transporter plays a major role. In the
Alejandro Carozzo, Federico Diez, Natalia Gomez, Maia Cabrera, Carina Shayo, Carlos Davio, Natalia Fernández   +6 more
doaj   +7 more sources

The xenobiotic transporter ABCC4/MRP4 promotes epithelial mesenchymal transition in pancreatic cancer [PDF]

Frontiers in Pharmacology
The xenobiotic transporter ABCC4/MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a more aggressive phenotype and metastatic propensity.
S. N. Gancedo, A. Sahores, A. Sahores, N. Gómez, N. Di Siervi, M. May, A. Yaneff, A. Yaneff, M. G. de Sousa Serro, N. Fraunhoffer, N. Fraunhoffer, N. Fraunhoffer, N. Dusetti, N. Dusetti, N. Dusetti, J. Iovanna, J. Iovanna, J. Iovanna, J. Iovanna, C. Shayo, C. A. Davio, C. A. Davio, B. González, B. González   +23 more
doaj   +5 more sources

Impact of Obesity and MASH on Zonal Hepatocellular Statin Exposure: Pharmacodynamic Insights From a Permeability-Limited Multicompartment Liver Model. [PDF]

CPT Pharmacometrics Syst Pharmacol
Obesity, MASH and Statins: Insights from a PBPK/PD Zonal Liver Model. ABSTRACT Statins are frequently prescribed for hyperlipidemia, a common comorbidity in patients with obesity and/or metabolic dysfunction‐associated steatohepatitis (MASH). However, limited knowledge exists on how MASH may alter statin disposition within hepatocytes where the statin ...
Murphy WA, Sjöstedt N, Mendes MS, Hartauer M, Brouwer KLR, Neuhoff S.   +5 more
europepmc   +2 more sources

Supplementation With Curcumin Exhibits Nephroprotective Effects in Cisplatin-Induced Acute Kidney Injury. [PDF]

Food Sci Nutr
(By Figdraw, ID: APASW31e60) (37.7 × 60 Mm). This study demonstrates that supplementation with curcumin alleviates cisplatin‐induced kidney injury. It works by restoring mitochondrial balance via the AMPK/PGC‐1α/Sirt3 pathway, reducing oxidative stress and apoptosis through the Nrf2/Keap1 and Bax/Bcl2/Caspase‐3 pathways, and correcting dysfunction in ...
Zhang M, Wang Y, Wang X, Zhou Y, Ma Y, Wu X.   +5 more
europepmc   +2 more sources

The Role of the Intestinal Microbiome in the Pathogenesis and Treatment of Hyperuricemia: A Review. [PDF]

Food Sci Nutr
This review summarizes the characteristics, prevalence, and treatment strategies of hyperuricemia, and subsequently examines its pathogenic mechanisms together with the potential roles and regulatory pathways of the gut microbiota in its alleviation.
Yang J, Chen J, Liu Z, Qu Y, Yue X, Yuan B, Li M.   +6 more
europepmc   +2 more sources

Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells. [PDF]

PLoS ONE
Uric acid induces radical oxygen species formation, endothelial inflammation, and endothelial dysfunction which contributes to the progression of atherosclerosis.
Karel H van der Pol, Jan Koenderink, Jeroen J M W van den Heuvel, Petra van den Broek, Janny Peters, Imke D W van Bunningen, Jeanne Pertijs, Frans G M Russel, Jim Koldenhof, Wim J Morshuis, Joris van Drongelen, Tom J J Schirris, Andries van der Meer, Gerard A Rongen   +13 more
doaj   +2 more sources

Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma

Biomedicines, 2021
Multidrug resistance-associated protein 4 (MRP4), a member of the adenosine triphosphate (ATP) binding cassette transporter family, pumps various molecules out of the cell and is involved in cell communication and drug distribution.
Haihong Hu, Yu Wang, Zhiyuan Qin, Wen Sun, Yanhong Chen, Jiaqi Wang, Yingying Wang, Jing Nie, Lu Chen, Sheng Cai, Lushan Yu, Su Zeng   +11 more
doaj   +1 more source

Changes in Gene Expression Profiling and Phenotype in Aged Multidrug Resistance Protein 4-Deficient Mouse Retinas

Antioxidants, 2021
Multidrug resistance protein 4 (MRP4) is an energy-dependent membrane transporter responsible for cellular efflux of a broad range of xenobiotics and physiological substrates.
Kyung Woo Kim, Sentaro Kusuhara, Atsuko Katsuyama-Yoshikawa, Sho Nobuyoshi, Megumi Kitamura, Sotaro Mori, Noriyuki Sotani, Kaori Ueda, Wataru Matsumiya, Akiko Miki, Takuji Kurimoto, Hisanori Imai, Makoto Nakamura   +12 more
doaj   +1 more source

Study of Endogen Substrates, Drug Substrates and Inhibitors Binding Conformations on MRP4 and Its Variants by Molecular Docking and Molecular Dynamics

Molecules, 2021
Multidrug resistance protein-4 (MRP4) belongs to the ABC transporter superfamily and promotes the transport of xenobiotics including drugs. A non-synonymous single nucleotide polymorphisms (nsSNPs) in the ABCC4 gene can promote changes in the structure ...
Edgardo Becerra, Giovanny Aguilera-Durán, Laura Berumen, Antonio Romo-Mancillas, Guadalupe García-Alcocer   +4 more
doaj   +1 more source

The modulation of transcriptional expression and inhibition of multidrug resistance associated protein 4 (MRP4) by analgesics and their primary metabolites

Current Research in Toxicology, 2020
During the course of a toxic challenge, changes in gene expression can manifest such as induction of metabolizing enzymes as a compensatory detoxification response.
Renato J. Scialis, Carolina I. Ghanem, José E. Manautou   +2 more
doaj   +1 more source