Results 91 to 100 of about 7,389 (203)
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 12, Page 2052-2064, December 2025.ABSTRACT Rosuvastatin (RSV), a potent HMG‐CoA reductase inhibitor, is widely used for the management of hyperlipidemia and prevention of cardiovascular disease. Its absorption and disposition are primarily transporter‐mediated, involving intestinal absorption by OATP2B1 and efflux by BCRP; hepatic uptake by OATP1B1, OATP1B3, OATP2B1, and NTCP; and ...
Ankit Balhara +2 more
wiley +1 more source
Glutathione status and the renal elimination of inorganic mercury in the Mrp2(-/-) mouse.
PLoS ONE, 2013 Multidrug resistance-associated proteins (MRP) 2 and 4 are localized in proximal tubular epithelial cells and participate in the renal elimination of xenobiotics. MRP2 has also been implicated in the renal and hepatic elimination of mercury.
Christy C Bridges +4 more
doaj +1 more source
Frontiers in Oncology, 2019 Endometrial cancer (EC) is the most common malignancy of the female reproductive tract. In this study, we clarified the clinical significance of CDKN2B antisense RNA 1 (CDKN2B-AS) gene, and its effects on paclitaxel sensitivity in EC.
Chao Shang +3 more
doaj +1 more source
The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway. [PDF]
, 2019 Caenorhabditis elegans larval development requires the function of the two Canal-Associated Neurons (CANs): killing the CANs by laser microsurgery or disrupting their development by mutating the gene ceh-10 results in early larval arrest. How these cells
Chien, Jason +5 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
Internal Medicine Journal, Volume 55, Issue 12, Page 2095-2098, December 2025.Abstract Aspirin resistance (AR) is linked to increased morbidity and mortality after cardiovascular and neurovascular procedures but has not been investigated after total hip arthroplasty (THA) and total knee arthroplasty (TKA). To investigate the incidence of AR in high‐risk patients after elective THA/TKA, we conducted a prospective cohort study of ...
Nameer van Oosterom +3 more
wiley +1 more source
Efflux transport of estrogen glucuronides by human MRP2, MRP3, MRP4 and BCRP [PDF]
The Journal of Steroid Biochemistry and Molecular Biology, 2018 Estrone, estradiol and estriol are endogenous human estrogens that are rapidly conjugated with glucuronic acid in both intestinal and hepatic epithelial cells. The resulting glucuronides, estrone-3-glucuronide (E1-G), estradiol-3- and 17-glucuronides (E2-3G and E2-17G), as well as estriol-3- and 16-glucuronides (E3-3G and E3-16G) are found in human ...
Järvinen Erkka +3 more
openaire +3 more sources
Blood Advances: Low-dose aspirin is a cornerstone of cardiovascular prevention in high-risk patients, inhibiting platelet cyclooxygenase (COX-1) and reducing thromboxane A2 (TXA2) production for 24 hours.
Rossella Liani +10 more
doaj +1 more source
Lactation during cholestasis: Role of ABC proteins in bile acid traffic across the mammary gland
Scientific Reports, 2017 Transporters involved in bile acid (BA) handling by the mammary gland are poorly understood. Here we have investigated the role of ABC proteins in blood-milk BA traffic and its sensitivity to maternal cholestasis. BA concentrations in rat and mouse serum
Alba M. G. Blazquez +5 more
doaj +1 more source
PLoS ONE, 2012 BackgroundThe farnesoid-x-receptor (FXR) is a bile acid sensor expressed in the liver and gastrointestinal tract. Despite FXR ligands are under investigation for treatment of cholestasis, a biochemical condition occurring in a number of liver diseases ...
Barbara Renga +10 more
doaj +1 more source