Results 111 to 120 of about 7,389 (203)

Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR− rats

Biochemical Pharmacology, 2005
Multidrug resistance-associated proteins (Mrps) are a group of ATP-dependent efflux transporters for organic anions. Mrp2 and Mrp4 are co-localized to the apical (brush-border) membrane domain of renal proximal tubules, where they may function together in the urinary excretion of organic anions.
Chen, C., Slitt, A.L., Dieter, M.Z., Tanaka, Y., Scheffer, G.L., Klaassen, C.D.   +5 more
openaire   +4 more sources

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport [PDF]

, 2014
Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletely understood. Here we report that prostaglandin signalling
A Becker-Heck, A Caron, AG Kramer-Zucker, AJ Slot, AM Lord, Anna Papierniak, AS Bogard, B Sarmah, B St-Jacques, BD Engel, Bin Zhou, BR Haxel, C Williams, CD Loftin, Chin Chiang, Daqing Jin, FG Russel, G Conseil, G Reid, GA Gross, Guangju Yu, Gwenaëlle Conseil, H Higginbotham, H Youk, Haiyan Wan, Iain A. Drummond, J Cao, J Reese, JA Boyce, Jarema Malicki, JD Amack, JD Schuetz, JE Dinchuk, Jeffrey D. Amack, Jianjian Sun, JJ Essner, JL Stubbs, JM Gerdes, JM Neugebauer, John D. Schuetz, Jonathan Fleming, JW Regan, M Fliegauf, M Leggas, M Tsujikawa, M Westerfield, MT Hoque, MV Nachury, PV Tran, R Langenbach, RJ Starner, S Long, S Narumiya, S Schuldiner, Satish Cheepala, SC Goetz, SC Goetz, SS Lopes, Susan P. C. Cole, Tao P. Zhong, TE North, Terri T. Ni, TP Zhong, TP Zhong, TY Besschetnova, W Driever, W Goessling, Wenyan Li, WL Smith, X Pan, X Yu, Y Fukuda, Y Omori, YI Cha, YI Cha, Z Wang   +75 more
core   +1 more source

Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients

Clinical Pharmacology &Therapeutics, Volume 118, Issue 3, Page 682-692, September 2025.
Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann, Dorien J. M. Peters, Amin Rostami‐Hodjegan, Patricia Wilson, Jill Norman, Jill Barber, Zubida M. Al‐Majdoub   +6 more
wiley   +1 more source

Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier

Cerebrospinal Fluid Research, 2010
Background Two rodent choroid plexus (CP) epithelial cell lines, Z310 and TR-CSFB, were compared with primary rat CP epithelial cells and intact CP tissue with respect to transport protein expression, function and tight junction (TJ) formation.
Kläs Juliane, Wolburg Hartwig, Terasaki Tetsuya, Fricker Gert, Reichel Valeska   +4 more
doaj   +1 more source

Perinatal Maturation of Drug Transporters and Claudin‐5 at the Blood–Brain Barrier

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
P‐gp expression in the developping human cortex increases with age. In the mouse, gatekeepers of BBB integrity and transport are upregulated: tighter blood–brain barrier, increased claudin 5/Slco1a4/P‐gp expression as well as enhanced P‐gp‐mediated BBB efflux.
Laetitia Federici, Salvatore Cisternino, Sylvain Auvity, Antoinette Gelot, Mathilde Becmeur‐Lefebvre, Maryline Favier, Gaelle Letort, Philippe Mailly, Martine Cohen‐Salmon, Anne‐Cécile Boulay   +9 more
wiley   +1 more source

The overexpression of MRP4 is related to multidrug resistance in osteosarcoma cells

Journal of Cancer Research and Therapeutics, 2015
Doxorubicin (Adriamycin, ADM) is an antimitotic drug used in the treatment of a wide range of malignant tumors, including acute leukemia, lymphoma, osteosarcoma, breast cancer, and lung cancer. Multidrug resistance-associated proteins (MRPs) are members of a superfamily of ATP-binding cassette (ABC) transporters, which can transport various molecules ...
Zhonghui, He, Beibei, Hu, Lina, Tang, Shui'er, Zheng, Yuanyu, Sun, Zan, Sheng, Yang, Yao, Feng, Lin   +7 more
openaire   +2 more sources

Tyrosine and aurora kinase inhibitors diminish transport function of multidrug resistance-associated protein (MRP) 4 and breast cancer resistance protein (BCRP)

ADMET and DMPK, 2016
Tyrosine and aurora kinases are important effectors in signal transduction pathways that are often involved in aberrant cancer cell growth. Tyrosine (TKI) and aurora (AKI) kinase inhibitors are anti-cancer agents specifically designed to target such ...
Rhiannon N. Hardwick, Marina Snellings, Brian C. Ferslew, Yang Lu, Kim L.R. Browuer   +4 more
doaj   +1 more source

Computational modeling of MRP4 and BSEP substrates and inhibitors (896.10)

The FASEB Journal, 2014
Drug‐induced liver injury (DILI) is an important cause of drug toxicity. Inhibition of MRP4, in addition to BSEP, might be a risk factor that is responsible for the development of cholestatic DILI. Recently, we demonstrated that MRP4 inhibition was associated with an increased cholestatic potential of drugs that are BSEP non‐inhibitors, while MRP4 ...
Peter Swaan, Kathleen Köck, Matthew Welch, Thomas Urban, Kim Brouwer   +4 more
openaire   +1 more source

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

Frequent Subgraph Mining in Outerplanar Graphs [PDF]

, 2010
In recent years there has been an increased interest in frequent pattern discovery in large databases of graph structured objects. While the frequent connected subgraph mining problem for tree datasets can be solved in incremental polynomial time, it ...
Horvath, Tamas, Ramon, Jan, Wrobel, Stefan   +2 more
core   +1 more source