Results 121 to 130 of about 7,389 (203)

Enhanced platelet sensitization is accompanied by increased expression of the transporter MRP4 and elevated plasma S1P levels in mild COVID-19 convalescents

Platelets
Viral infections can lead to platelet activation and hemostatic complications. However, the extent to which platelet reactivity remains altered after convalescence, contributing to long-term health impairments as observed after COVID-19 is not yet fully ...
Céline Tolksdorf, Andrea Seidel, Christian Baume, Eileen Moritz, Karen Saljé, Kathrin Lehmann, Karsten Becker, Ulrike Garscha, Thomas Thiele, Edzard Schwedhelm, Mirjam von Lucadou, Mladen V. Tzvetkov, Stefan Engeli, Gabriele Jedlitschky, Bernhard H. Rauch   +14 more
doaj   +1 more source

NUDT15 c.415C>T Polymorphism Predicts 6-MP Induced Early Myelotoxicity in Patients with Acute Lymphoblastic Leukemia Undergoing Maintenance Therapy

Pharmacogenomics and Personalized Medicine, 2021
Aswin Anand Pai, Ajith Mohan, Esther Sathya Bama Benjamin, Raveen Stephen Stallon Illangeswaran, Infencia Xavier Raj, Nancy Beryl Janet, Arun Kumar Arunachalam, ML Kavitha, Uday Kulkarni, Anup J Devasia, NA Fouzia, Aby Abraham, Alok Srivastava, Biju ...
Pai AA, Mohan A, Benjamin ESB, Illangeswaran RSS, Xavier Raj I, Janet NB, Arunachalam AK, Kavitha ML, Kulkarni U, Devasia AJ, Fouzia NA, Abraham A, Srivastava A, George B, Mathews V, Korula A, Balasubramanian P   +16 more
doaj  

Decreased expression of breast cancer resistance protein in the duodenum in patients with obstructive cholestasis [PDF]

, 2006
Background/Aims: The expression of transporters involved in bile acid homeostasis is differentially regulated during obstructive cholestasis. Since the drug efflux transporter breast cancer resistance protein (BCRP) is known to transport bile acids, we ...
Adachi Y, Brendel C, Christian Zimmermann, Christoph Beglinger, Denk GU, Denson LA, Dietrich CG, Dietrich CG, Ee PL, Frank Lehmann, Freeman LA, Geier A, Gutmann H, Heike Gutmann, Hruz P, Imai Y, Janvilisri T, Jonker JW, Juergen Drewe, Jung D, Jung D, Kamisako T, Klucken J, Li N, Lown KS, Lu TT, Luigi Terracciano, Maliepaard M, Miyake K, Petr Hruz, Plebani M, Popowski K, Schellens JH, Smith M, Stedman CA, Stellaard F, Suzuki M, Taipalensuu J, Tanaka Y, Tanaka Y, Trauner M, Ulrich Beuers, van Herwaarden AE, Volk EL, Wagner M, Xie W, Yu L, Zimmermann C, Zollner G   +48 more
core   +1 more source

Fxr−/− mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids

Journal of Lipid Research, 2006
Farnesoid X receptor knockout (Fxr−/−) mice cannot upregulate the bile salt export pump in bile acid loading or cholestatic conditions. To investigate whether Fxr−/− mice differ in bile acid detoxification compared with wild-type mice, we performed a ...
Hanns-Ulrich Marschall, Martin Wagner, Karl Bodin, Gernot Zollner, Peter Fickert, Judith Gumhold, Dagmar Silbert, Andrea Fuchsbichler, Jan Sjövall, Michael Trauner   +9 more
doaj   +1 more source

Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes

The FASEB Journal, 2011
Recent studies indicate that members of the multidrug‐resistance protein ( MRP ) family belonging to ATP binding cassette type C ( ABCC ) membrane proteins extrude cyclic nucleotides from various cell types.
Yassine, Sassi, Aniella, Abi-Gerges, Jeremy, Fauconnier, Nathalie, Mougenot, Steven, Reiken, Kobra, Haghighi, Evangelia G, Kranias, Andrew R, Marks, Alain, Lacampagne, Stefan, Engelhardt, Stephane N, Hatem, Anne-Marie, Lompre, Jean-Sébastien, Hulot   +12 more
openaire   +4 more sources

Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development.

PLoS ONE, 2014
The pro-carcinogenic effects of prostaglandin E2 (PGE2) in colonic mucosa are not only regulated by the rates between Cyclooxygenase-2 (COX-2) biosynthesis and 15-Hydroxyprostaglandin Dehydrogenase (15-PGDH)-dependent degradation but also the steady ...
Carina Pereira, Sara Queirós, Ana Galaghar, Hugo Sousa, Pedro Pimentel-Nunes, Catarina Brandão, Luís Moreira-Dias, Rui Medeiros, Mário Dinis-Ribeiro   +8 more
doaj   +1 more source

GDF11 induces chemosensitization in human hepatocellular carcinoma cells by decreasing drug-efflux transporters [PDF]

Exploration of Digestive Diseases
Aim: Hepatocellular carcinoma (HCC) accounts for 90% of liver tumors and is the fourth leading cause of cancer-related deaths worldwide. Current treatments have poor outcomes for HCC, highlighting the urgent need for new and effective therapies.
Natanael German-Ramirez, Monserrat Gerardo-Ramírez, Guadalupe I. Domínguez-Gómez, Felipe Masso-Rojas, Araceli Paez-Arenas, Benjamin Perez-Aguilar, Leticia Bucio-Ortiz, Veronica Souza-Arroyo, Roxana U. Miranda-Labra, María Concepción Gutierrez-Ruiz, Arturo Simoni-Nieves, Luis E. Gomez-Quiroz   +11 more
doaj   +1 more source

Daganatos sejtek rezisztenciáját gátló vegyületek fejlesztése = Development of compounds targeting multidrug resistant cancer [PDF]

, 2009
A korszerű daganatellenes terápia jelentős sikerei ellenére a kemoterápiával szemben fellépő rezisztencia (multidrog rezisztencia, MDR) továbbra is megoldásra váró klinikai kihívás.
Szakács, Gergely
core  

PXR-mediated Metabolism During Pregnancy and Cholestasis

, 2009
Nuclear receptors, including the pregnane x receptor (PXR) and the farnesoid x receptor (FXR), regulate the expression of genes that maintain bile acid (BA) homeostasis. Intrahepatic cholestasis of pregnancy (ICP) is a common gestational liver disease
Owen, Bryn Myers, Owen, Bryn Myers
core   +1 more source

Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1.

PLoS ONE, 2019
Demethoxycurcumin (DMC) is a safe and natural food-coloring additive, as well as an agent with several therapeutic properties. However, extensive glucuronidation in vivo has resulted in its poor bioavailability. In this study, we aimed to investigate the
Beibei Zhang, Jing Yang, Zifei Qin, Shishi Li, Jinjin Xu, Zhihong Yao, Xiaojian Zhang, Frank J Gonzalez, Xinsheng Yao   +8 more
doaj   +1 more source