Results 11 to 20 of about 7,389 (203)

Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport.

PLoS ONE, 2019
The blood-brain barrier (BBB) is a dynamic and complex interface between blood and the central nervous system (CNS). It protects the brain by preventing toxic substances from entering the brain but also limits the entry of therapeutic agents. ATP-binding
Xiaofen Zhao, Yangfang Li, Kun Du, Yuqin Wu, Ling Liu, Shan Cui, Yan Zhang, Jin Gao, Richard F Keep, Jianming Xiang   +9 more
doaj   +4 more sources

Structural basis of prostaglandin efflux by MRP4. [PDF]

Nat Struct Mol Biol, 2022
AbstractMRP4 is unique among the C family of ATP-binding cassette transporters for its role in translocating prostanoids, an important group of signaling molecules derived from unsaturated fatty acids. Using a reconstituted system, we report that a pair of prostaglandins (PGs) and the sulfonated-sterol DHEA-S preferentially enhance the ATPase activity ...
Pourmal S, Green E, Bajaj R, Chemmama IE, Knudsen GM, Gupta M, Sali A, Cheng Y, Craik CS, Kroetz DL, Stroud RM.   +10 more
europepmc   +5 more sources

Sorting Nexin 27 Interacts with Multidrug Resistance-associated Protein 4 (MRP4) and Mediates Internalization of MRP4 [PDF]

Journal of Biological Chemistry, 2012
Multidrug resistance-associated protein 4 (MRP4/ABCC4) makes a vital contribution to the bodily distribution of drugs and endogenous compounds because of its cellular efflux abilities. However, little is known about the mechanism regulating its cell surface expression.
Hisamitsu, Hayashi, Sotaro, Naoi, Takayuki, Nakagawa, Toru, Nishikawa, Hiroyuki, Fukuda, Shinobu, Imajoh-Ohmi, Ayano, Kondo, Kiyotaka, Kubo, Takashi, Yabuki, Asami, Hattori, Masakazu, Hirouchi, Yuichi, Sugiyama   +11 more
openaire   +2 more sources

Interactions between Hepatic Mrp4 and Sult2a as Revealed by the Constitutive Androstane Receptor and Mrp4 Knockout Mice [PDF]

Journal of Biological Chemistry, 2004
The ABC transporter, Mrp4, transports the sulfated steroid DHEA-s, and sulfated bile acids interact with Mrp4 with high affinity. Hepatic Mrp4 levels are low, but increase under cholestatic conditions. We therefore inferred that up-regulation of Mrp4 during cholestasis is a compensatory mechanism to protect the liver from accumulation of hydrophobic ...
Assem, Mahfoud, Schuetz, Erin G., Leggas, Markos, Sun, Daxi, Yasuda, Kazuto, Reid, Glen, Zelcer, Noam, Adachi, Masashi, Strom, Stephen, Evans, Ronald M., Moore, David D., Borst, Piet, Schuetz, John D.   +12 more
openaire   +2 more sources

A conserved WXXE motif is an apical delivery determinant of ABC transporter C subfamily isoforms

Cell Structure and Function, 2023
ATP-binding cassette transporter isoform C7 (ABCC7), also designated as cystic fibrosis transmembrane conductance regulator (CFTR), is exclusively targeted to the apical plasma membrane of polarized epithelial cells.
Md Shajedul Haque, Yoshikazu Emi, Masao Sakaguchi   +2 more
doaj   +1 more source

Gene Expression Profiling of Corpus luteum Reveals Important Insights about Early Pregnancy in Domestic Sheep [PDF]

, 2020
The majority of pregnancy loss in ruminants occurs during the preimplantation stage, which is thus the most critical period determining reproductive success. Here, we performed a comparative transcriptome study by sequencing total mRNA from corpus luteum
Honkatukia, Mervi, Kantanen, Juha, Li, Meng-Hua, Peippo, Jaana, Pokharel, Kisun, Weldenegodguad, Melak   +5 more
core   +1 more source

Functional Expression of Multidrug Resistance Protein 4 MRP4/ABCC4 [PDF]

SLAS Discovery, 2019
To study the function and structure of membrane proteins, high quantities of pure and stable protein are needed. One of the first hurdles in accomplishing this is expression of the membrane protein at high levels and in a functional state. Membrane proteins are naturally expressed at low levels, so finding a suitable host for overexpression is ...
David Hardy, Roslyn M. Bill, Anass Jawhari, Alice J. Rothnie   +3 more
openaire   +3 more sources

Specific inhibition of the transporter MRP4/ABCC4 affects multiple signaling pathways and thrombus formation in human platelets

Haematologica, 2022
The multidrug resistance protein 4 (MRP4) is highly expressed in platelets and several lines of evidence point to an impact on platelet function. MRP4 represents a transporter for cyclic nucleotides as well as for certain lipid mediators. The aim of the
Robert Wolf, Sophie Grammbauer, Raghavendra Palankar, Céline Tolksdorf, Eileen Moritz, Andreas Böhm, Mahmoud Hasan, Annika Hafkemeyer, Andreas Greinacher, Mladen V. Tzvetkov, Bernhard H. Rauch, Gabriele Jedlitschky   +11 more
doaj   +1 more source

Role of MRP4 and MRP5 in biology and chemotherapy [PDF]

AAPS PharmSci, 2002
Nucleotide efflux (especially cyclic nucleotides) from a variety of mammalian tissues, bacteria, and lower eukaryotes has been studied for several decades. However, the molecular identity of these nucleotide efflux transporters remained elusive, despite extensive knowledge of their kinetic properties and inhibitor profiles.
J, Sampath, M, Adachi, S, Hatse, L, Naesens, J, Balzarini, R M, Flatley, L H, Matherly, J D, Schuetz   +7 more
openaire   +2 more sources

Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4 [PDF]

Structure, 2022
SUMMARYMultidrug resistance-associated protein 4 (MRP4) is an ATP-binding cassette (ABC) transporter expressed at multiple tissue barriers where it actively extrudes a wide variety of drug compounds. Overexpression of MRP4 provides resistance to clinically used antineoplastic and antiviral agents, making it a highly attractive therapeutic target for ...
Magnus Bloch, Isha Raj, Tillmann Pape, Nicholas M.I. Taylor   +3 more
openaire   +3 more sources