Results 191 to 200 of about 7,389 (203)

Unimpaired immune functions in the absence of Mrp4 (Abcc4)

Immunology Letters, 2009
Dendritic cell (DC) migration to draining lymph nodes is important for the initiation of an effective immune response. Recently we reported that the human ATP-binding cassette (ABC) transporter multidrug resistance protein 4 (MRP4 and ABCC4) is required for the migration of human DC. Since the ABC transporter MRP1 (ABCC1) was previously shown to play a
van de Ven, R., Groot, J.D., Reurs, A.W., Wijnands, P.G.J.T.B., van de Wetering, K., Schuetz, JD, de Gruijl, T.D., Scheper, R.J., Scheffer, G.L.   +8 more
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Multidrug resistance protein 4 (MRP4/ABCC4)

Trends in Pharmacological Sciences, 2008
Multidrug resistance protein (MRP) 4 is a member of the MRP/ABCC subfamily of ATP-binding cassette transporters, which are capable of pumping a wide variety of endogenous and xenobiotic organic anionic compounds out of the cell. In addition to its role in the body distribution and renal excretion of a wide variety of antiviral, cytostatic, antibiotic ...
Russel, Frans G M, Koenderink, Jan B, Masereeuw, R.   +2 more
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Inhibition of MRP4 alleviates sepsis-induced acute lung injury in rats

International Immunopharmacology, 2019
This study was undertaken to examine the regulatory role of multidrug resistance-associated protein 4 (MRP4) in an experimental model of sepsis-induced acute lung injury in rats. Sepsis was induced by cecal ligation and puncture in anesthetized rats.
Wenfang, Xia, Huanming, Zhang, Zhou, Pan, Guang, Li, Qingshan, Zhou, Dan, Hu, Yu, Liu   +6 more
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Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione

The International Journal of Biochemistry & Cell Biology, 2004
Multidrug resistance proteins (MRPs) are ATP-dependent export pumps that mediate the export of organic anions. ABCC1 (MRP1), ABCC2 (MRP2) and ABCC3 (MRP3) are all able to facilitate the efflux of anionic conjugates including glutathione (GSH), glucuronide and sulfate conjugates of xenobiotics and endogenous molecules.
Bai, J., Lai, L., Tan, T.M.C., Yeo, H.C., Goh, B.C.   +4 more
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Variability in human hepatic MRP4 expression: influence of cholestasis and genotype

The Pharmacogenomics Journal, 2007
The multidrug resistance protein 4 (MRP4) is an efflux transporter involved in the transport of endogenous substrates and xenobiotics. We measured MRP4 mRNA and protein expression in human livers and found a 38- and 45-fold variability, respectively. We sequenced 2 kb of the 5'-flanking region, all exons and intron/exon boundaries of the MRP4 gene in ...
Gradhand, U., Lang, T., Schaeffeler, E., Glaeser, H., Tegude, H., Klein, K., Fritz, P., Jedlitschky, G., Kroemer, H., Bachmakov, I., Anwald, B., Kerb, R., Zanger, U., Eichelbaum, M., Schwab, M., Fromm, M.   +15 more
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Avian renal proximal tubule epithelium urate secretion is mediated by Mrp4

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
Birds are uricotelic and, like humans, maintain high plasma urate concentrations (∼300 μM). The majority of their urate waste, as in humans, is eliminated by renal proximal tubular secretion; however, the mechanism of urate transport across the brush-border membrane of the intact proximal tubule epithelium during secretion is uncertain.
Amy M, Bataille, James, Goldmeyer, J Larry, Renfro   +2 more
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MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

Nature Medicine, 1999
Dideoxynucleosides, which are potent inhibitors of HIV reverse transcriptase and other viral DNA polymerases, are a common component of highly active anti-retroviral therapy (HAART) (ref. 1). Six reverse transcriptase inhibitors have been approved for human use: azidothymidine; 2'3'-dideoxycytidine; 2'3'-dideoxyinosine; 2', 3'-didehydro-3 ...
J D, Schuetz, M C, Connelly, D, Sun, S G, Paibir, P M, Flynn, R V, Srinivas, A, Kumar, A, Fridland   +7 more
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Response: MRP4 gene polymorphisms and treatment response in adult ALL

Blood, 2009
We thank Bruggemann and colleagues for their interest in our paper[1][1] that recently reported an association between MRP4 gene polymorphisms (regulatory T-1393C and A934C leading to Lys304Asn substitution) and outcome in childhood acute lymphoblastic leukemia (ALL) patients treated on Dana ...
Krajinovic, M., Ansari Djaberi, Marc Georges, Sinnett, D.   +2 more
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Expression, Solubilisation and Purification of MRP4

2022
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Tu1734 Inhibition of MRP4 Enhances the Wound Repair Process:

Gastroenterology, 2013
Chandrima Sinha, Anjaparavanda P. Naren
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