Results 21 to 30 of about 7,389 (203)
Medicina, 2022 Background and objectives: The multidrug resistance protein 4 (MRP4) is a member of the ABC transporter, which has been extensively related to many types of cancer including leukemia.
Edgardo Becerra +3 more
doaj +1 more source
Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice [PDF]
Journal of Clinical Investigation, 2011 Multidrug resistance-associated protein 4 (MRP4, also known as Abcc4) regulates intracellular levels of cAMP and cGMP in arterial SMCs. Here, we report our studies of the role of MRP4 in the development and progression of pulmonary arterial hypertension (PAH), a severe vascular disease characterized by chronically elevated pulmonary artery pressure and
Hara, Yannis +8 more
openaire +3 more sources
Discovery of novel multidrug resistance protein 4 (MRP4) inhibitors as active agents reducing resistance to anticancer drug 6-Mercaptopurine (6-MP) by structure and ligand-based virtual screening. [PDF]
PLoS ONE, 2018 Multidrug resistance protein 4 (MRP4/ABCC4) is an ATP-binding cassette (ABC) transporter. It is associated with multidrug resistance (MDR), which is becoming a growing challenge to the treatment of cancer and infections.
Ya Chen +5 more
doaj +1 more source
Mrp4−/− mice have an impaired cytoprotective response in obstructive cholestasis [PDF]
Hepatology, 2006 Mrp4 is a member of the multidrug resistance–associated gene family that is expressed on the basolateral membrane of hepatocytes and undergoes adaptive upregulation in response to cholestatic injury or bile acid feeding.
Albert, Mennone +7 more
openaire +2 more sources
Interaction of Oxazaphosphorines with Multidrug Resistance-Associated Protein 4 (MRP4) [PDF]
The AAPS Journal, 2010 Multidrug resistance-associated protein 4 (MRP4) is an organic anion efflux pump capable of transporting nucleoside, nucleotide analogs, and cyclic nucleotide. MRP4 could have an influence on the resistance and transport of the two oxazaphosphorines, cyclophosphamide (CP) and ifosfamide (IF).
Zhang, J., Ng, K.-Y., Ho, P.C.
openaire +2 more sources
Frontiers in Pharmacology, 2021 Formononetin is one of the main active compounds of traditional Chinese herbal medicine Astragalus membranaceus. However, disposition of formononetin via sulfonation pathway remains undefined.
Fanye Liu +10 more
doaj +1 more source
Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]
, 2017 There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas +7 more
core +2 more sources
Forskolin Modifies Retinal Vascular Development inMrp4-Knockout Mice [PDF]
Investigative Opthalmology & Visual Science, 2012 Multidrug resistance protein 4 (MRP4) effluxes a wide variety of endogenous compounds, including cyclic adenosine monophosphate (cAMP), and is exclusively expressed in vascular endothelial cells (ECs) of the retina. This study aimed to investigate the role of MRP4 in retinal vascular development.The retinal vascular phenotype of Mrp4(-/-) mice was ...
Wataru, Matsumiya +7 more
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Journal of Pharmaceutical Analysis, 2023 Renal tubular secretion mediated by organic anion transporters (OATs) and the multidrug resistance-associated protein 4 (MRP4) is an important means of drug and toxin excretion. Unfortunately, there are no biomarkers to evaluate their function.
Yanrong Ma +5 more
doaj +1 more source
Oncology Letters, 2017 It has been demonstrated that docetaxel (DTX) may improve the overall survival of patients with castration-resistant prostate cancer (CRPC). However, its effectiveness is limited with time, and tumor escape is eventually inevitable. DTX resistance is the main reason for the failure of chemotherapy for CRPC.
Yun-Fei, Li +5 more
openaire +3 more sources