Results 31 to 40 of about 7,389 (203)

The absence of mrp4 has no effect on the recruitment of neutrophils and eosinophils into the lung after LPS, cigarette smoke or allergen challenge.

PLoS ONE, 2013
The multidrug resistance protein 4 (Mrp4) is an ATP-binding cassette transporter that is capable of exporting the second messenger cAMP from cells, a process that might regulate cAMP-mediated anti-inflammatory processes.
Jürgen Schymeinsky, Hannah Mayer, Christopher Tomsic, Cornelia Tilp, John D Schuetz, Yunhai Cui, Lutz Wollin, Florian Gantner, Klaus J Erb   +8 more
doaj   +1 more source

Discovery of Novel Symmetrical 1,4-Dihydropyridines as Inhibitors of Multidrug-Resistant Protein (MRP4) Efflux Pump for Anticancer Therapy

Molecules, 2020
Despite the development of targeted therapies in cancer, the problem of multidrug resistance (MDR) is still unsolved. Most patients with metastatic cancer die from MDR.
Henry Döring, David Kreutzer, Christoph Ritter, Andreas Hilgeroth   +3 more
doaj   +1 more source

Apoptosome activation, an important molecular instigator in 6-mercaptopurine induced Leydig cell death. [PDF]

, 2015
Leydig cells are crucial to the production of testosterone in males. It is unknown if the cancer chemotherapeutic drug, 6-mercaptopurine (6 MP), produces Leydig cell failure among adult survivors of childhood acute lymphoblastic leukemia. Moreover, it is
Bao, Ju, Chemaitilly, Wassim, Frase, Sharon, Green, Daniel M, Janke, Laura, Lynch, John, Morgan, Jessica A, Opferman, Joseph T, Panetta, John C, Schuetz, John D, Wang, Yao, Zheng, Jie   +11 more
core   +1 more source

Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice [PDF]

Blood, 2015
Key PointsIn vivo and in vitro thrombus formation is altered in MRP4-deficient mice. MRP4 modulates the cAMP–protein kinase A platelet signaling pathway.
Benoit, Decouture, Elise, Dreano, Tiphaine, Belleville-Rolland, Orjeta, Kuci, Blandine, Dizier, Amine, Bazaa, Bérard, Coqueran, Anne-Marie, Lompre, Cécile V, Denis, Jean-Sébastien, Hulot, Christilla, Bachelot-Loza, Pascale, Gaussem   +11 more
openaire   +2 more sources

Lack of multidrug resistance-associated protein 4 (Mrp4) alters the kinetics of acetaminophen toxicity

Toxicology Reports, 2019
Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver injury in humans and a common chemical model to investigate genetic determinants of susceptibility to drug-induced liver injury (DILI).
Ajay C Donepudi, Michael J. Goedken, John D. Schuetz, José E Manautou   +3 more
doaj   +1 more source

The Intake of Coffee Increases the Absorption of Aspirin in Mice by Modifying Gut Microbiome

Pharmaceutics, 2022
The absorption of orally administered aspirin into the blood was affected by gastrointestinal environmental factors such as gut pH, digestive enzymes, and microbiota. The intake of coffee affects the pharmacological effects of aspirin.
Jeon-Kyung Kim, Min Sun Choi, Hye Hyun Yoo, Dong-Hyun Kim   +3 more
doaj   +1 more source

ABCC4/MRP4: a MYCN-regulated transporter and potential therapeutic target in neuroblastoma.

Frontiers in Oncology, 2012
Resistance to cytotoxic drugs is thought to be a major cause of treatment failure in childhood neuroblastoma, and members of the ATP-binding cassette (ABC) transporter superfamily may contribute to this phenomenon by active efflux of chemotherapeutic ...
Tony eHuynh, Murray D Norris, Michelle eHaber, Michelle J Henderson   +3 more
doaj   +1 more source

Homozygous of MRP4 Gene rs1751034 C Allele Is Related to Increased Risk of Intravenous Immunoglobulin Resistance in Kawasaki Disease

Frontiers in Genetics, 2021
Background: Kawasaki disease (KD) is a systemic vasculitis in childhood, which mainly causes damage to coronary arteries, and intravenous immunoglobulin (IVIG) is the initial therapy. IVIG resistance increased risk of coronary complication in KD.
Yanfei Wang, Yufen Xu, Ping Huang, Di Che, Zhouping Wang, Xijing Huang, Xiaofei Xie, Wei Li, Li Zhang, Xiaoqiong Gu   +9 more
doaj   +1 more source

Role of MRP transporters in regulating antimicrobial drug inefficacy and oxidative stress-induced pathogenesis during HIV-1 and TB infections. [PDF]

, 2015
Multi-Drug Resistance Proteins (MRPs) are members of the ATP binding cassette (ABC) drug-efflux transporter superfamily. MRPs are known to regulate the efficacy of a broad range of anti-retroviral drugs (ARV) used in highly active antiretroviral therapy (
Barber, Paul, Batrakova, Elena V., Mondal, Debasis, Nair, Madhavan, Roy, Upal, Tse-Dinh, Yuk-Ching   +5 more
core   +5 more sources

Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy [PDF]

Molecular and Cellular Biology, 2004
The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To explore this role, we generated Mrp4-deficient mice. Unexpectedly, these mice showed enhanced accumulation of the anticancer agent topotecan in brain tissue and cerebrospinal fluid (CSF). Further studies demonstrated that topotecan was an Mrp4 substrate and that cells
Markos, Leggas, Masashi, Adachi, George L, Scheffer, Daxi, Sun, Peter, Wielinga, Guoqing, Du, Kelly E, Mercer, Yanli, Zhuang, John C, Panetta, Brad, Johnston, Rik J, Scheper, Clinton F, Stewart, John D, Schuetz   +12 more
openaire   +4 more sources