Uric acid transporters BCRP and MRP4 involved in chickens uric acid excretion
BMC Veterinary Research, 2019 Background Breast cancer resistance protein (BCRP) and multidrug resistance protein 4 (MRP4) are involved in uric acid excretion in humans and mice.
Xuedong Ding +11 more
doaj +1 more source
New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway [PDF]
, 2015 G protein coupled receptors (GPCRs) linked to stimulatory G (Gs) proteins (GsPCRs) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases, which differ considerably in their cellular distribution and ...
Duarte, Thiago +2 more
core +4 more sources
Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins [PDF]
, 2012 Background: Methionine (Met) residues in proteins can be readily oxidized by reactive oxygen species to Met sulfoxide (MetO). MetO is a promising physiological marker of oxidative stress and its inefficient repair by MetO reductases (Msrs) has been ...
Gladyshev, Vadim N +5 more
core +2 more sources
Gene induction during differentiation of human monocytes into dendritic cells: an integrated study at the RNA and protein levels [PDF]
, 2001 Changes in gene expression occurring during differentiation of human monocytes into dendritic cells were studied at the RNA and protein levels. These studies showed the induction of several gene classes corresponding to various biological functions ...
Angénieux, C. +9 more
core +3 more sources
Aspirin-dependent effects on purinergic P2Y1 receptor express [PDF]
, 2019 Chronic treatment with aspirin in healthy volunteers (HVs) is associated with recovery of adenosine diphosphate (ADP)-induced platelet activation. The purinergic P2Y1 receptor exerts its effects via a Gq-protein, which is the same biochemical pathway ...
Alemanno, Laura +8 more
core +1 more source
A Fluorescent Cell-Based Technique for Monitoring Efflux of MRP4 [PDF]
American Journal of Molecular Biology, 2020 Background: Overexpression of efflux pumps is the drug resistance and adaptation mechanism employed by some eukaryotes and bacteria to transport endogenous and chemotherapeutic compounds from the intracellular to the extracellular environment. Aim: The study aimed at establishing a fluorescent cell-based assay to monitor the efflux activities of an ABC-
Tombari Pius Monsi +2 more
openaire +1 more source
Allergology International, 2023 Background: Chronic rhinosinusitis is a common disease of the nasal cavity and is classified into two major endotypes, which are neutrophilic and eosinophilic.
Tomohisa Iinuma +9 more
doaj +1 more source
Analysis of the MRP4 Drug Resistance Profile in Transfected NIH3T3 Cells [PDF]
Journal of the National Cancer Institute, 2000 Multidrug resistance-associated protein (MRP) 1 and canalicular multispecific organic anion transporter (cMOAT or MRP2) are adenosine triphosphate-binding cassette transporters that confer resistance to anticancer agents. In addition to these two transporters, there are at least four other human MRP subfamily members (MRP3 through MRP6).
K, Lee, A J, Klein-Szanto, G D, Kruh
openaire +2 more sources
Biomolecules, 2015 Apoptosis (programmed cell death) is regarded as ultimate differentiation of the cell. We have recently demonstrated that a targeted delivery of Dd-MRP4 (Dictyostelium mitochondrial ribosomal protein S4) suppresses specifically the proliferation of the
Yasuo Maeda
doaj +1 more source
Impact of Parenteral Nutrition Versus Fasting on Hepatic Bile Acid Production and Transport in a Rabbit Model of Prolonged Critical Illness [PDF]
, 1986 Cholestatic liver dysfunction frequently occurs during critical illness. Administration of parenteral nutrition (PN) is thought to aggravate this.
Vanwijngaerden, Yoo-Mee +6 more
core +2 more sources