Results 51 to 60 of about 7,389 (203)

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia [PDF]

, 2014
Less than a third of adults patients with acute myeloid leukemia (AML) are cured by current treatments, emphasizing the need for new approaches to therapy.
Beyrath, Julien, Bruzzone, Ariana, Cany, Jeannette, Copsel, Sabrina Natalia, Davio, Carlos Alberto, May, Maria, Russel, Frans G. M., Shayo, Carina Claudia, Wargon, Victoria   +8 more
core   +2 more sources

Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice [PDF]

Journal of Biological Chemistry, 2012
The physiological role of multidrug resistance protein 4 (Mrp4, Abcc4) in the testes is unknown. We found that Mrp4 is expressed primarily in mouse and human Leydig cells; however, there is no current evidence that Mrp4 regulates testosterone production.
Jessica A, Morgan, Satish B, Cheepala, Yao, Wang, Geoff, Neale, Masashi, Adachi, Deepa, Nachagari, Mark, Leggas, Wenchen, Zhao, Kelli, Boyd, Raman, Venkataramanan, John D, Schuetz   +10 more
openaire   +2 more sources

Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in earlyand late-stage cholestasis [PDF]

, 2017
AIM: To ascertain whether cholestasis affects the expression of two CYP3A isoforms (CYP3A1 and CYP3A2) and of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Albertoni, Laura, Baldo, Vincenzo, Baldovin, Tatjana, Carrara, Maria, DALLA POZZA, Arianna, De Martin, Sara, Floreani, Annarosa, Gabbia, Daniela, Lazzari, Roberta, Zigiotto, Giorgia   +9 more
core   +1 more source

Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4

Communications Biology, 2023
AbstractHuman multidrug resistance protein 4 (hMRP4, also known as ABCC4), with a representative topology of the MRP subfamily, translocates various substrates across the membrane and contributes to the development of multidrug resistance. However, the underlying transport mechanism of hMRP4 remains unclear due to a lack of high-resolution structures ...
Ying Huang, Chenyang Xue, Liangdong Wang, Ruiqian Bu, Jianqiang Mu, Yong Wang, Zhongmin Liu   +6 more
openaire   +3 more sources

Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations.

PLoS ONE, 2011
During chronic kidney disease (CKD), there is a progressive accumulation of toxic solutes due to inadequate renal clearance. Here, the interaction between uremic toxins and two important efflux pumps, viz. multidrug resistance protein 4 (MRP4) and breast
Henricus A M Mutsaers, Lambertus P van den Heuvel, Lauke H J Ringens, Anita C A Dankers, Frans G M Russel, Jack F M Wetzels, Joost G Hoenderop, Rosalinde Masereeuw   +7 more
doaj   +1 more source

Multidrug Resistance-Associated Protein 2 Deficiency Aggravates Estrogen-Induced Impairment of Bile Acid Metabolomics in Rats

Frontiers in Physiology, 2022
Multidrug resistance-associated protein 2 (Mrp2) mediates biliary secretion of anionic endobiotics and xenobiotics. Genetic alteration of Mrp2 leads to conjugated hyperbilirubinemia and predisposes to the development of intrahepatic cholestasis of ...
Fatemeh Alaei Faradonbeh, Hana Lastuvkova, Jolana Cermanova, Milos Hroch, Zuzana Nova, Martin Uher, Petra Hirsova, Petr Pavek, Stanislav Micuda   +8 more
doaj   +1 more source

MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease

Pharmacological Research, 2016
This review focuses on multidrug resistance protein 4 (MRP4 or ABCC4) that has recently been shown to play a role in cAMP homeostasis, a key-pathway in vascular biology and in platelet functions. In vascular system, recent data provide evidence that inhibition of MRP4 prevents human coronary artery smooth muscle cell proliferation in vitro and in vivo,
Tiphaine, Belleville-Rolland, Yassine, Sassi, Benoit, Decouture, Elise, Dreano, Jean-Sébastien, Hulot, Pascale, Gaussem, Christilla, Bachelot-Loza   +6 more
openaire   +2 more sources

Clinicopathological Impact of ABCC1/MRP1 and ABCC4/MRP4 in Epithelial Ovarian Carcinoma [PDF]

BioMed Research International, 2013
Ovarian cancer is the main cause of death from gynaecological malignancies. In spite of the efficacy of platinum-paclitaxel treatment in patients with primary epithelial ovarian carcinoma, platinum-based chemotherapy is not curative and resistance remains one of the most important causes of treatment failure.
M. Bagnoli, G. L. Beretta, L. Gatti, S. Pilotti, P. Alberti, E. Tarantino, M. Barbareschi, S. Canevari, D. Mezzanzanica, P. Perego   +9 more
openaire   +3 more sources

Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity

Scientific Reports, 2020
The expression and function of some xenobiotic transporters varies according to the time of day, causing the dosing time-dependent changes in drug disposition and toxicity.
Mizuki Kato, Yuya Tsurudome, Takumi Kanemitsu, Sai Yasukochi, Yuki Kanado, Takashi Ogino, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo   +8 more
doaj   +1 more source

Dexamethasone induces an imbalanced fetal-placental-maternal bile acid circulation: involvement of placental transporters

BMC Medicine, 2021
Background The use of prenatal dexamethasone remains controversial. Our recent studies found that prenatal dexamethasone exposure can induce maternal intrahepatic cholestasis and have a lasting adverse influence on bile acid (BA) metabolism in the ...
Wen Huang, Jin Zhou, Juanjuan Guo, Wen Hu, Guanghui Chen, Bin Li, Yajie Wen, Yimin Jiang, Kaili Fu, Huichang Bi, Yuanzhen Zhang, Hui Wang   +11 more
doaj   +1 more source