Blockade of multidrug resistance associated proteins aggravates acute pancreatitis and blunts atrial natriuretic factor beneficial effect in rats: Role of MRP4/ABCC4 [PDF]
, 2015 We previously reported that atrial natriuretic factor (ANF) stimulates secretin-evoked cAMP efflux through multidrug resistance-associated protein 4 (MRP4) in the exocrine pancreas.
Bianciotti, Liliana Graciela +6 more
core +1 more source
Effect of oxidative stress on ABC transporters: contribution to epilepsy pharmacoresistance [PDF]
, 2017 Epilepsy is a neurological disorder affecting around 1%-2% of population worldwide and its treatment includes use of antiepileptic drugs to control seizures. Failure to respond to antiepileptic drug therapy is a major clinical problem and over expression
Grewal, G. K. +5 more
core +2 more sources
Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness [PDF]
Scientific Reports, 2020 AbstractRecent findings show that MRP4 is critical for pancreatic ductal adenocarcinoma (PDAC) cell proliferation. Nevertheless, the significance of MRP4 protein levels and function in PDAC progression is still unclear. The aim of this study was to determine the role of MRP4 in PDAC tumor aggressiveness. Bioinformatic studies revealed that PDAC samples
Ana Sahores +10 more
openaire +4 more sources
Molecular Therapy: Methods & Clinical Development, 2015 The ATP-binding cassette transporter MRP4 (encoded by ABCC4) regulates membrane cyclic nucleotides concentrations in arterial cells including smooth muscle cells.
Caroline Claude +8 more
doaj +1 more source
Measurement and clinical significance of biomarkers of oxidative stress in humans [PDF]
, 2017 Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants. Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing ...
Altieri, Fabio +2 more
core +3 more sources
MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation
Journal of Cell Science, 2019 ABSTRACT Mammalian spermatozoa must undergo biochemical and structural changes to acquire the capacity for fertilization, in a process known as capacitation. Activation of PKA enzymes is essential for capacitation, and thus cAMP levels are tightly regulated during this process. Previously, we demonstrated that during capacitation, bovine
C. A. I. Alonso +8 more
openaire +3 more sources
Multidrug Resistance Protein-4 Influences Aspirin Toxicity in Human Cell Line
Mediators of Inflammation, 2015 Overexpression of efflux transporters, in human cells, is a mechanism of resistance to drug and also to chemotherapy. We found that multidrug resistance protein-4 (MRP4) overexpression has a role in reducing aspirin action in patients after bypass ...
Isabella Massimi +6 more
doaj +1 more source
Influence of Genetic Polymorphisms in Prostaglandin E2 Pathway (COX-2/HPGD/SLCO2A1/ABCC4) on the Risk for Colorectal Adenoma Development and Recurrence after Polypectomy [PDF]
, 2016 OBJECTIVES: Deregulation of prostaglandin E2 (PGE2) levels reported in colorectal carcinogenesis contributes to key steps of cancer development. Our aim was to evaluate the influence of the genetic variability in COX-2/HPGD/SLCO2A1/ABCC4 PGE2 pathway ...
Brandão, C. +8 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source
Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases.
Mohitosh Biswas +3 more
wiley +1 more source