Transport and Permeation Properties of Dapivirine: Understanding Potential Drug-Drug Interactions
Pharmaceutics, 2022 The dapivirine (DPV) vaginal ring was developed by the nonprofit International Partnership for Microbicides (IPM) for reducing the risk of HIV infection.
Ruohui Zheng +7 more
doaj +1 more source
Recent advances in the exploration of the bile salt export pump (BSEP/ABCB11) function [PDF]
, 2016 ntroduction: The bile salt export pump (BSEP/ABCB11), residing in the apical membrane of hepatocyte, mediates the secretion of bile salts into the bile.
Homolya, László +1 more
core +1 more source
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Dicloxacillin and flucloxacillin are β‐lactamase‐resistant penicillin antibiotics that have been in clinical use for over 50 years. While both antibiotics are known to induce cytochrome P450 enzymes, there is limited information available regarding their interactions with drug transporters.
Noora Sjöstedt +7 more
wiley +1 more source
Hepatic bile acids and bile acid-related gene expression in pregnant and lactating rats [PDF]
, 2013 Background. Significant physiological changes occur during pregnancy and lactation. Intrahepatic cholestasis of pregnancy (ICP) is a liver disease closely related to disruption of bile acid homeostasis.
Dan Zhang +4 more
core +1 more source
Advanced Science, Volume 13, Issue 5, 27 January 2026.KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen +19 more
wiley +1 more source
The ABCC6 transporter : what lessons can be learnt from other ATP-binding cassette transporters? [PDF]
, 2013 ABC transporters represent a large family of ATP-driven transmembrane transporters involved in uni- or bidirectional transfer of a large variety of substrates.
De Paepe, Anne +2 more
core +2 more sources
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, Volume 45, Issue 1, Page 37-68, January/February 2026.Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
Clinical and genetic factors associated with kidney tubular dysfunction in a real-life single centre cohort of HIV-positive patients [PDF]
, 2017 BACKGROUND: Tenofovir (TDF) is one of the most widely used antiretroviral drug. Despite the high degree of tolerability a small percentage of patients experienced alteration in tubular function during TDF use.
Atzori, C +8 more
core +3 more sources
Изучение психологической готовности студентов к саморазвитию и самосовершенствованию [PDF]
, 2009 Multidrug resistance proteins (MRPs) are transmembrane proteins with the potential to export a wide range of substances in the extracellular space preventing cells from toxification.
Канивец, Марина Викторовна
core
Impact of anatase and rutile titanium dioxide nanoparticles on uptake carriers and efflux pumps in Caco-2 gut epithelial cells [PDF]
, 2015 International audienceTiO2 microparticles are widely used in food products, where they are added as a white food colouring agent. This food additive contains a significant amount of nanoscale particles; still the impact of TiO2 nanoparticles (TiO2-NPs ...
Barreau, Frédérick +9 more
core +3 more sources