Results 81 to 90 of about 7,389 (203)
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.ABSTRACT Patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) may exhibit altered pharmacokinetics (PK) and pharmacodynamics (PD) of drugs compared with healthy populations. However, no physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model has been specifically developed for MASLD.
Shanshan Zhao, Lan Zhang
wiley +1 more source
A burst of ABC genes in the genome of the polyphagous spider mite Tetranychus urticae [PDF]
, 2013 Background: The ABC (ATP-binding cassette) gene superfamily is widespread across all living species. The majority of ABC genes encode ABC transporters, which are membrane-spanning proteins capable of transferring substrates across biological membranes by
Edward Osborne +5 more
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Molecular Oncology, Volume 19, Issue 12, Page 3729-3749, December 2025.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Scientific Reports, 2021 Transporters in the human liver play a major role in the clearance of endo- and xenobiotics. Apical (canalicular) transporters extrude compounds to the bile, while basolateral hepatocyte transporters promote the uptake of, or expel, various compounds ...
Csilla Ambrus +4 more
doaj +1 more source
Advanced Science, Volume 12, Issue 48, December 29, 2025.Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie +18 more
wiley +1 more source
BMC Cancer, 2022 Background Although several novel resistant breast cancer cell lines have been established, only a few resistant breast cancer cell lines overexpress breast cancer resistance proteins (BCRP).
Hee-Jeong Lee, Cheol-Hee Choi
doaj +1 more source
Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line
Annals of Hepatology, 2021 Introduction and objectives: Free and conjugated bile acids (BA's) cannot cross cell membranes; therefore, a particular transport system is required by the cell.
Suilma Ivette Pérez-Pineda +4 more
doaj +1 more source
Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]
, 2019 Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y. +3 more
core +3 more sources
Tenofovir renal proximal tubular toxicity is regulated By OAT1 and MRP4 transporters [PDF]
Laboratory Investigation, 2011 Tenofovir disoproxil fumarate (TDF) is an oral prodrug and acyclic nucleotide analog of adenosine monophosphate that inhibits HIV-1 (HIV) reverse transcriptase. A growing subset of TDF-treated HIV(+) individuals presented with acute renal failure, suggesting tenofovir-associated kidney-specific toxicity.
Kohler, James J. +7 more
openaire +2 more sources
Breast Cancer: Basic and Clinical Research, 2016 Elevated levels of cyclooxygenase-2 (COX-2) and prostaglandin E 2 (PGE 2 ) are indicators of a poor prognosis in breast cancer. Using several independent publicly available breast cancer gene expression databases, we investigated other members of the PGE
Tyler J. Kochel +2 more
doaj +1 more source