Results 161 to 170 of about 79,621 (260)

Underexplored Ligand‐Binding Features of FabI From Staphylococcus aureus and Escherichia coli: A Comparative Pharmacophoric Modeling and Surface Mapping Approach

open access: yesChemMedChem, Volume 21, Issue 15, 14 August 2026.
Antimicrobial resistance highlights the urgent need for novel FabI inhibitors. Using an integrated computational approach combining ConPhar pharmacophore modeling, FTMap surface mapping, and PLIP interaction profiling across experimental structures and structures from MD simulations, we identified a conserved binding core (Y156/Y157, A95) and ...
Pedro Tenório T. F. Leite   +10 more
wiley   +1 more source

Increased Risk of Environmental and Endemic Infectious Diseases in Sjögren's Disease: A Retrospective Analysis (2015–2023)

open access: yesACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective Sjögren's disease (SjD) is a chronic autoimmune disease with a complex etiology, where pathogens may influence disease development or progression. Although SjD is not communicable, environmental and endemic pathogen exposures may influence its onset or progression.
Swetha K. Shankar   +3 more
wiley   +1 more source

3D‐Printable, Biodegradable, and Conductive/Piezoionic Hydrogel ‘E‐Skin’ With Robust Antibacterial Properties for Wound Healing and Wireless Human‐Machine Interface Sensing

open access: yesAdvanced Functional Materials, Volume 36, Issue 63, 6 August 2026.
A multifunctional MXene‐integrated GelMA/alginate hydrogel reinforced with TEMPO‐modified nanocellulose is engineered via dynamic covalent, ionic, and hydrogen bonding. The resulting piezoelectric, adhesive, antimicrobial, and 3D‐printable patch enables motion sensing and accelerates wound healing by promoting keratinocyte migration and collagen ...
Myoungjoon Jeon   +11 more
wiley   +1 more source

Rapid exploration of anti-MRSA components from plants of Salvia. [PDF]

open access: yesNat Prod Bioprospect
Huang H   +6 more
europepmc   +1 more source

Visible‐Light Photoredox Catalysis in the Intramolecular Dicarbonylation of Alkenes: Catalyst‐Dependent Divergent Syntheses of Both 1,4‐Dicarbonyls and α‐Hydroxy‐β,γ‐Unsaturated Lactams From 1,2‐Dicarbonyls

open access: yesAdvanced Synthesis &Catalysis, Volume 368, Issue 15, 1 August 2026.
Catalyst‐dependent divergent syntheses were developed. Intramolecular dicarbonylation of vinyl halides under metal‐free either thermal or visible light photocatalytic conditions were explored to produce a series of 1,4‐dicarbonyls with two different carbonyl moieties and a lactam ring.
Chia‐Lin Li, Che‐Chien Chang
wiley   +1 more source

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

open access: yesAdvanced Science, Volume 13, Issue 43, 3 August 2026.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo   +7 more
wiley   +1 more source

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