Results 71 to 80 of about 35,927 (289)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
PublicaThis study examines the digital readiness of micro and small enterprises (MSEs) in rural Indonesia, aiming to evaluate their readiness and develop a specialized model tailored to rural challenges.
Elisa Susanti, Siti Alia, Ridho Harta
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
International Journal of Science and Engineering, 2014 The objective of this reseach were to: (1) analyze the level of autonomous of mikro and small entreprise (SMEs) entrepreneurs are empowered through Coorporate Social Responsibility (CSR); (2) analyze the dominant factors that influence autonomous of ...
Faizal Maad +3 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Sharp MSE Bounds for Proximal Denoising [PDF]
Foundations of Computational Mathematics, 2015 Denoising has to do with estimating a signal $x_0$ from its noisy observations $y=x_0+z$. In this paper, we focus on the "structured denoising problem", where the signal $x_0$ possesses a certain structure and $z$ has independent normally distributed entries with mean zero and variance $σ^2$.
Oymak, Samet, Hassibi, Babak
openaire +4 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Adoption of Information and Communications Technology in Rural Micro and Small Enterprises (MSEs) : Case of MSEs in South Indian State of Kerala, India [PDF]
ICT plays a significant role in the life of enterprises. Micro and Small Enterprises (MSEs) have to be familiar and in tune with ICT applications, within the context of fast evolving global market dynamics.
Koshy, Perumal
core +1 more source
Child Exploitation and the FIFA World Cup: A review of risks and protective interventions [PDF]
, 2013 This review was commissioned by the Child Abuse Programme (CAP) of Oak Foundation, a large international philanthropic organisation. It forms part of CAP’s effort to win societal rejection of practices such as the sexual exploitation of children and ...
Brackenridge, C +7 more
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