Results 91 to 100 of about 24,399,079 (272)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

“Things That Were, and Things That Are, and Things That Yet May Be”: The J.R.R. Tolkien Manuscript Collection at Marquette University [PDF]

, 2017
A talk on the Tolkien Archive at Marquette University’s Rayner Memorial Library in Milwaukee, Wisconsin—its origins, usefulness, and current reorganization ...
Fliss, William M.
core   +2 more sources

Foreign labor, peer‐networking and agricultural efficiency in the Italian dairy sector

Agribusiness, EarlyView.
Abstract While the presence of immigrants in the agricultural sector is widely acknowledged, the empirical evidence on its economic consequences is lacking, especially from a microeconomic perspective. Using the Farm Accountancy Data Network panel data for Italian dairy farms in the period 2008–2018, the present study investigates the relationship ...
Federico Antonioli, Simone Severini, Mauro Vigani   +2 more
wiley   +1 more source

Prognostic Impact of Histologic Subtypes in Mismatch Repair‐Deficient/Microsatellite Instability‐High Colorectal Cancer: A Single‐Center Retrospective Study of 1127 Stage 0–IV Patients

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Deficient mismatch repair/microsatellite instability‐High (dMMR/MSI‐H) colorectal cancer (CRC) generally confers a favorable survival yet is paradoxically enriched for poorly differentiated (Por) histology, which is linked to aggressive behavior.
Tomoyuki Momma, Hirokazu Okayama, Sohei Hayashishita, Hiroya Suzuki, Masanori Katagata, Takuro Matsumoto, Daisuke Ujiie, Shun Chida, Wataru Sakamoto, Koji Kono   +9 more
wiley   +1 more source

A high-resolution lithospheric magnetic field model of China and surroundings by using CHAMP, <i>Swarm</i>, CSES-1, and MSS-1 satellite magnetic measurements and aeromagnetic anomaly data

Earth and Planetary Physics
The CUG_CLMFM3D series comprises high-resolution three-dimensional lithospheric magnetic field models for China and its surroundings. The first version, CUG_CLMFM3Dv1, is a spherical cap harmonic model integrating the WDMAMv2 (World Digital Magnetic Anomaly Map version 2) global magnetic anomaly grid and nearly a decade of CHAMP (Challenging ...
Pan Zhang, JinSong Du, Liang Yin, Qing Yan, JiaXuan Zhang, HouPu Li, Keke Zhang, Chao Chen   +7 more
openaire   +2 more sources

Preparation of Pectin Aerogels From Flaxseed and Evaluation of Their Potential as Hemostatic Agents: Water Absorption Characteristics

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Flaxseed has been used extensively to extract flaxseed oil and drugs used for breast cancer treatment. Flaxseed contains a considerable amount of pectin in addition. We extracted pectin from flaxseed and prepared pectin aerogels by the steps of de‐esterification, gelation, solvent exchange and supercritical CO2 drying.
Jin‐A Choe, Hyon‐Tae Pak, Kwang‐Myong Cha, Song‐Su Ma, Chol‐Ung Kim, Yong‐Son Rim   +5 more
wiley   +1 more source

Spectral characterization of the LANDSAT-D multispectral scanner subsystems [PDF]

Relative spectral response data for the multispectral scanner subsystems (MSS) to be flown on LANDSAT-D and LANDSAT-D backup, the protoflight and flight models, respectively, are presented and compared to similar data for the Landsat 1,2, and 3 ...
Barker, J. L., Markham, B. L.
core   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

Technical characteristics of Macau Science Satellite-1A

Earth and Planetary Physics
The Macau Science Satellite-1 (MSS-1) is the first space science satellite jointly developed on the Chinese mainland and in Macau. It comprises two satellites, named MSS-1A and MSS-1B, and holds considerable importance in China’s space exploration ...
Yan Li, Yong Zhang, TianYu Zhang, ShiGeng Yuan, Wen Su, JingShan Sun, Fei Feng, BingJun Cheng, Yi Jiang, PengFei Liu, GuiHong Xiao, QingMei Fan, ChunYu Yu, Ming Wang, Qi Xiao, ChuNan Miao   +15 more
doaj   +1 more source

An analytical Model which Determines the Apparent T1 for Modified Look-Locker Inversion Recovery (MOLLI) -- Analysis of the Longitudinal Relaxation under the Influence of Discontinuous Balanced and Spoiled Gradient Echo Readouts

, 2018
Quantitative nuclear magnetic resonance imaging (MRI) shifts more and more into the focus of clinical research. Especially determination of relaxation times without/and with contrast agents becomes the foundation of tissue characterization, e.g.
Bauer, Wolfgang Rudolf, Kampf, Thomas, Reiter, Theresa   +2 more
core   +1 more source