Results 121 to 130 of about 36,668 (274)

Exome Sequencing Identifies Variants in MLH1 and ERBB2 as Potential Cancer‐Predisposing Factors in Familial Early‐Onset Colorectal Cancer

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Colorectal cancer (CRC) has raised considerable health concerns worldwide, with increasing incidence rates, specifically among younger populations. Despite remarkable progress in diagnosing and treating various diseases, the genetic basis of CRC remains only partially understood.
Behnaz Bagheri   +7 more
wiley   +1 more source

Longitudinal correlation between X‐ray and MRI findings in medial compartment knee osteoarthritis: Insights into early cartilage loss and structural changes

open access: yesKnee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
ABSTRACT Purpose Knee osteoarthritis (OA) is a common joint disorder assessed using radiographic (X‐ray) and magnetic resonance imaging (MRI). While X‐rays are accessible, MRI provides detailed insights into meniscus and cartilage. Few studies have evaluated the correlation between X‐ray and MRI findings in knee OA longitudinally.
Do Weon Lee   +3 more
wiley   +1 more source

Durable response to bispecific PD-1/ICOS antibody and ipilimumab in advanced microsatellite-stable colorectal cancer: a case report

open access: yesCurrent Problems in Cancer: Case Reports
Microsatellite-stable (MSS) or mismatch repair proficient (MMRp) colorectal cancer typically exhibits resistance to immune checkpoint blockade. Tumor mutational burden (TMB) and DNA repair defects may increase immunogenicity and sensitivity to novel ...
Sarah Jung   +6 more
doaj   +1 more source

Clinical Features and Dental Pathologies in Maxillary Sinus Fungal Balls and Odontogenic Sinusitis

open access: yesThe Laryngoscope, EarlyView.
This international, multicenter study compared clinical and dental characteristics of maxillary sinus fungal balls (MSFB), odontogenic MSFB (MSFBO), and odontogenic sinusitis (ODS). When MSFB and MSFBO were compared, MSFBO was associated with extruded root canal material and dental implant protrusion; when MSFBOs and ODS were compared, ODS was ...
Eunice Im   +32 more
wiley   +1 more source

Effect of Heat Treatment Parameters on Microstructure, Hardness, and Corrosion Resistance of Martensitic Stainless Steel X30Cr13 (AISI 420B)

open access: yesMaterials and Corrosion, EarlyView.
The hardness and corrosion resistance of the martensitic stainless steel X30Cr13 depend directly on the applied heat treatment. This article describes and discusses the relationships between alloy composition, thermodynamic phase stabilities, heat treatment parameters, resulting microstructures, and achievable corrosion resistance. To investigate these
Adrian Evia Ocampo   +3 more
wiley   +1 more source

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

open access: yesMacromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Performance evaluation of regional weather predictions with the Model for Prediction Across Scales – Atmosphere (MPAS‐A) over the Maritime Continent

open access: yesQuarterly Journal of the Royal Meteorological Society, EarlyView.
As part of the ongoing efforts to develop next‐generation forecasting systems at the Meteorological Service Singapore, this study presents the setup and evaluation of the SINGV_NG(MPAS) system. Overall, the SINGV_NG(MPAS) system outperforms European Centre for Medium‐Range Weather Forecasts (ECMWF) deterministic forecasts in capturing heavy rainfall ...
I‐Han Chen   +7 more
wiley   +1 more source

HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAFV600E-mutant microsatellite stable colorectal cancer

open access: yesJournal for ImmunoTherapy of Cancer
Background B-Raf proto-oncogene, serine/threonine kinase (BRAF)V600E-mutant microsatellite stable (MSS) colorectal cancer (CRC) constitutes a distinct CRC subgroup, traditionally perceived as minimally responsive to standard therapies.
Xin Li   +10 more
doaj   +1 more source

Historical remote sensing highlights long‐term persistence of Emperor Penguin (Aptenodytes forsteri) colonies

open access: yesRemote Sensing in Ecology and Conservation, EarlyView.
Remote sensing can reveal population dynamics of Antarctic penguin colonies. In this study, we analyze emperor penguin (Aptenodytes forsteri) guano stains in remote sensing imagery and discover colony presence predating known records for 18 colonies across Antarctica.
Martynas Bielinis   +3 more
wiley   +1 more source

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