Results 51 to 60 of about 37,578 (264)

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, EarlyView.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

Desafios para o parcelamento dos assentamentos de reforma agrária sob a perspectiva ambiental a partir da experiência do MST em Goiás

Revista NERA, 2019
O planejamento dos assentamentos rurais não se constituiu numa prática frequente da política de reforma agrária no Brasil. As reduzidas iniciativas institucionais resultaram da experiência dos Planos de Desenvolvimento do Assentamento (PDAs) e da ...
Karla Emmanuela Ribeiro Hora, Rogério Antonio Mauro, Manoel Calaça   +2 more
doaj   +1 more source

Local MST Computation with Short Advice [PDF]

Theory of Computing Systems, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fraigniaud, Pierre, Korman, Amos, Lebhar, Emmanuelle   +2 more
openaire   +3 more sources

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

AND‐Logic‐Gated Aptamer Switch for Precise Targeting and Regulation of RNA G‐Quadruplexes

Angewandte Chemie, EarlyView.
An AND‐logic‐gated aptamer switch enables tumor‐selective activation of RNA G‐quadruplex (rG4)‐targeting function. By combining cell‐surface recognition and intracellular redox sensing, the system achieves precise regulation of disease‐relevant RNA structures exclusively in tumor cells, with minimal off‐target effects in normal cells, offering a ...
Dan Wang, Ying Feng, Chun Kit Kwok
wiley   +2 more sources

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Spin‐Selective Oxygen Evolution in Chiral Molecule‐Intercalated Layered Double Hydroxides

Advanced Science, EarlyView.
This hybrid electrocatalyst utilizes chiral phenylalanine intercalation within layered double hydroxides to boost oxygen evolution. Acting as a spin filter via the chiral‐induced spin selectivity effect, the material directs electron transfer along a lower‐energy pathway.
Chih‐Ying Huang, Cheng‐Rong Wu, Yang‐Sheng Lu, Yu‐Ying Chang, Chia‐Che Chang, Tsung‐Hsin Liu, Che‐Lun Lee, Jessie Shiue, Yu‐Chang Lin, Wei‐Tsung Chuang, Huang‐Ming Tsai, Ya‐Lun Ho, Jau‐Wern Chiou, Hua‐Shu Hsu, Shao‐Sian Li, Chia‐Chun Chen, Way‐Faung Pong, Chun‐Wei Chen   +17 more
wiley   +1 more source

Escola Nossa Senhora Aparecida: um movimento histórico de luta por escola DOI: 10.5965/1984724614262013187

Revista PerCursos, 2013
O referido artigo trata da história da Escola de Educação Infantil e Ensino Fundamental Nossa Senhora Aparecida, localizada no município de Passos Maia/SC.
Vagner Luiz Kominkiéwic, Jéferson Silveira Dantas   +1 more
doaj