Results 71 to 80 of about 72,051 (311)

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Experiências escolares e estratégia política: da pedagogia socialista à atualidade do MST [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação, Programa de Pós-Graduação em Educação, Florianópolis, 2015.A pesquisa tem por objetivo analisar as relações entre educação, escola e estratégia socialista, nas ...
Bahniuk, Caroline
core  

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Lithographic patterning of conformal thin films on 3D structures using Scaffold-architected Lift-off masks

Nature Communications
Micro- and nanoscale patterning of conformal thin-film coatings on the exterior surfaces of complex three-dimensional (3D) structures is essential for emerging applications such as soft robotics, photonics, and functional 3D-printed MEMS devices. However,
Xinxin Liu, Zifan Che, Zofia Maj, Lee-Lun Lai, Kristinn B. Gylfason, Valentin Dubois, Shyamprasad N. Raja, Göran Stemme, Frank Niklaus   +8 more
doaj   +1 more source

MST-RC of one-tier CSI industry indices.

, 2016
(a) shows the MST-RC of one-tier CSI industry indices during the whole study period (2002/1/6-2015/7/1). (b) shows the MST-RC of one-tier CSI industry indices on October 2008 (Window length = 6 months).
Haishu Qiao (2816716), Yue Xia (664918), Ying Li (38224)   +2 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Escola Nossa Senhora Aparecida: um movimento histórico de luta por escola DOI: 10.5965/1984724614262013187

Revista PerCursos, 2013
O referido artigo trata da história da Escola de Educação Infantil e Ensino Fundamental Nossa Senhora Aparecida, localizada no município de Passos Maia/SC.
Vagner Luiz Kominkiéwic, Jéferson Silveira Dantas   +1 more
doaj  

Latency, Capacity, and Distributed MST

CoRR, 2019
We study the cost of distributed MST construction in the setting where each edge has a latency and a capacity, along with the weight. Edge latencies capture the delay on the links of the communication network, while capacity captures their throughput (in this case, the rate at which messages can be sent).
John Augustine 0001, Seth Gilbert, Fabian Kuhn, Peter Robinson 0002, Suman Sourav   +4 more
openaire   +3 more sources

Um (re)trato pedagógico a partir do olhar de educadores/as de jovens e adultos do MST [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação. Programa de Pós-Graduaçã em Educação.Esta dissertação analisa as significações da prática docente e política de educadores e educadoras que trabalham com ...
Lenzi, Lúcia Helena Corrêa
core  

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source