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Thoracic Aortic Aneurysm Development Is Dependent on Membrane Type-1 Matrix Metalloproteinase Activity and Abundance [PDF]
BiomoleculesThoracic aortic aneurysm (TAA) results from dysregulated remodeling of the extracellular matrix mediated by matrix metalloproteinase (MMP) activity. Previous studies identified elevated membrane type-1 MMP (MT1-MMP) abundance and activity during TAA ...
Ying Xiong +8 more
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MT1-MMP as a Key Regulator of Metastasis
Cells, 2023 Membrane type1-matrix metalloproteinase (MT1-MMP) is a member of metalloproteinases that is tethered to the transmembrane. Its major function in cancer progression is to directly degrade the extracellular matrix components, which are mainly type I–III ...
Noritaka Tanaka, Takeharu Sakamoto
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Biomolecules, 2022 Homomultimerization of MT1-MMP (membrane type 1 matrix metalloproteinase) through the hemopexin, transmembrane, and cytoplasmic domains plays a very important role in the activation of proMMP-2 and the degradation of pericellular collagen.
Marton Fogarasi, Simona Dima
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Regulation of mitochondrial dynamics and function by melatonin type 1 receptor in parkinson’s disease [PDF]
Cellular and Molecular Life SciencesParkinson’s disease (PD) is a neurodegenerative disease characterized by dopaminergic neuron loss and Lewy bodies in the substantia nigra. Abnormal mitochondrial function and accumulated α-synuclein (α-syn) are key etiological factors of PD.
Xiao-Bo Wang +10 more
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MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity [PDF]
Cell DiscoveryObesity has been linked to an increased risk of cognitive impairment and dementia in later life. Although aging and obesity are both associated with cognitive decline, it remains unclear how they interact to affect cognitive function across the lifespan ...
Pallavi Asthana +22 more
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Potential target within the tumor microenvironment - MT1-MMP
Frontiers in ImmunologyMatrix metalloproteinases are integral to the modification of the tumor microenvironment and facilitate tumor progression by degrading the extracellular matrix, releasing cytokines, and influencing the recruitment of immune cells.
Jinlong Liu +12 more
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Metallothionein 1: A New Spotlight on Inflammatory Diseases
Frontiers in Immunology, 2021 MT1 has been demonstrated to be an essential stress protein in maintaining physiological balance and regulating immune homeostasis. While the immunological involvement of MT1 in central nervous system disorders and cancer has been extensively ...
Hanying Dai +4 more
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MT1‐MMP: A tethered collagenase [PDF]
Journal of Cellular Physiology, 2004 AbstractGene ablation in mice offers a powerful tool to assay in vivo the role of selected molecules. Numerous new mouse models of matrix metalloproteinases (MMP) deficiency have been developed in the past 5 years and have yielded a new understanding of the role of MMPs while also putting to rest assumptions based on data predating the days of mouse ...
Kenn Holmbeck +3 more
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Cytoplasmic Tail of MT1-MMP: A Hub of MT1-MMP Regulation and Function
International Journal of Molecular Sciences, 2023 MT1-MMP (MMP-14) is a multifunctional protease that regulates ECM degradation, activation of other proteases, and a variety of cellular processes, including migration and viability in physiological and pathological contexts. Both the localization and signal transduction capabilities of MT1-MMP are dependent on its cytoplasmic domain that constitutes ...
Katerina Strouhalova +3 more
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