Results 151 to 160 of about 37,316 (165)

Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. [PDF]

J Exp Med
Toral-Rios D, Long JM, Ulrich JD, Yu J, Strickland MR, Han X, Holtzman DM, Cashikar AG, Paul SM.   +8 more
europepmc   +1 more source

Connectomic reconstruction predicts visual features used for navigation. [PDF]

Nature
Garner D, Kind E, Lai JYH, Nern A, Zhao A, Houghton L, Sancer G, Wolff T, Rubin GM, Wernet MF, Kim SS.   +10 more
europepmc   +1 more source

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Melatonin MT1 and MT2 receptor ERK signaling is differentially dependent on Gi/o and Gq/11 proteins

Journal of Pineal Research, 2020
G protein‐coupled receptors (GPCRs) transmit extracellular signals into cells by activating G protein‐ and β‐arrestin‐dependent pathways. Extracellular signal‐regulated kinases (ERKs) play a central role in integrating these different linear inputs ...
Min Chen, E. Cecon, A. Karamitri, Wenwen Gao, R. Gerbier, Raise Ahmad, R. Jockers   +6 more
semanticscholar   +1 more source

Melatonin MT1 receptors regulate the Sirt1/Nrf2/Ho‐1/Gpx4 pathway to prevent α‐synuclein‐induced ferroptosis in Parkinson's disease

Journal of Pineal Research
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons and aggregation of α‐synuclein (α‐syn). Ferroptosis, a form of cell death induced by iron accumulation and lipid peroxidation, is involved in ...
Qian-kun Lv, Kang-Xin Tao, Xiaoqin Yao, Meng-Zhu Pang, Bing-Er Cao, C. Liu, Fen Wang   +6 more
semanticscholar   +1 more source

Sleep well. Untangling the role of melatonin MT1 and MT2 receptors in sleep

Journal of Pineal Research, 2019
The pharmacological potential of targeting selectively melatonin MT1 or MT2 receptors has not yet been exploited in medicine. Research using selective MT1/MT2 receptor ligands and MT1/MT2 receptor knockout mice has indicated that the activation of MT2 ...
G. Gobbi, S. Comai
semanticscholar   +1 more source

Melatonin regulates the activities of ovary and delays the fertility decline in female animals via MT1/AMPK pathway

Journal of Pineal Research, 2019
Female fertility irreversibly declines with aging, and this is primarily associated with the decreased quality and quantity of oocytes. To evaluate whether a long‐term of melatonin treatment would improve the fertility of aged mice, different ...
Lu Zhang, Zhenzhen Zhang, Jing Wang, Dongying Lv, Tianqi Zhu, Feng Wang, X. Tian, Yujun Yao, Pengyun Ji, Guoshi Liu   +9 more
semanticscholar   +1 more source

Melatonin suppresses milk fat synthesis by inhibiting the mTOR signaling pathway via the MT1 receptor in bovine mammary epithelial cells

Journal of Pineal Research, 2019
Milk fat content is an important criterion for assessing milk quality and is one of the main target traits of dairy cattle breeding. Recent studies have shown the importance of melatonin in regulating lipid metabolism, but the potential effects of ...
Yujuan Wang, Wenli Guo, Haichao Xu, Keqiong Tang, L. Zan, Wucai Yang   +5 more
semanticscholar   +1 more source

Role of the Fusarium oxysporum metallothionein Mt1 in resistance to metal toxicity and virulence.

Metallomics, 2019
Soil organisms exhibit high tolerance to heavy metals, probably acquired through evolutionary adaptation to contaminated environments. Essentially, metal tolerance in fungi involves several specific and non-specific mechanisms that include metal efflux ...
Damaris Lorenzo-Gutiérrez, Lucía Gómez-Gil, J. Guarro, M. Roncero, A. Fernández-Bravo, J. Capilla, Loida López-Fernández   +6 more
semanticscholar   +1 more source

Body weight regulation via MT1-MMP-mediated cleavage of GFRAL

Nature Metabolism, 2022
C. F. Chow, Xuanming Guo, Pallavi Asthana, Shuo Zhang, Sheung Kin Ken Wong, Samane Fallah, Sijia Che, Susma Gurung, Zening Wang, Ki Baek Lee, Xin Ge, Shiyang Yuan, Haoyu Xu, J. P. K. Ip, Zhixin Jiang, Lixiang Zhai, Jiayan Wu, Yijing Zhang, A. K. Mahato, M. Saarma, Cheng-yuan Lin, H. Kwan, Tao Huang, Aiping Lyu, Zhongjun Zhou, Z. Bian, Hoi Leong Xavier Wong   +26 more
semanticscholar   +1 more source

Cryo-EM structure of the human MT1–Gi signaling complex

Nature Structural & Molecular Biology, 2021
H. Okamoto, H. Miyauchi, A. Inoue, F. Raimondi, Hirokazu Tsujimoto, T. Kusakizako, W. Shihoya, K. Yamashita, Ryoji Suno, N. Nomura, Takuya Kobayashi, S. Iwata, T. Nishizawa, O. Nureki   +13 more
semanticscholar   +1 more source