MT1-MMP as a Key Regulator of Metastasis [PDF]
Cells, 2023 Membrane type1-matrix metalloproteinase (MT1-MMP) is a member of metalloproteinases that is tethered to the transmembrane. Its major function in cancer progression is to directly degrade the extracellular matrix components, which are mainly type I–III ...
Noritaka Tanaka, Takeharu Sakamoto
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The Catalytic Domain Mediates Homomultimerization of MT1-MMP and the Prodomain Interferes with MT1-MMP Oligomeric Complex Assembly [PDF]
Biomolecules, 2022 Homomultimerization of MT1-MMP (membrane type 1 matrix metalloproteinase) through the hemopexin, transmembrane, and cytoplasmic domains plays a very important role in the activation of proMMP-2 and the degradation of pericellular collagen.
Marton Fogarasi, Simona Dima
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Potential target within the tumor microenvironment - MT1-MMP [PDF]
Frontiers in ImmunologyMatrix metalloproteinases are integral to the modification of the tumor microenvironment and facilitate tumor progression by degrading the extracellular matrix, releasing cytokines, and influencing the recruitment of immune cells.
Jinlong Liu +12 more
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Regulation of MT1-MMP Activity through Its Association with ERMs [PDF]
Cells, 2020 Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development.
Henar Suárez +7 more
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The Expanding Role of MT1-MMP in Cancer Progression [PDF]
Pharmaceuticals, 2019 For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been recognized as a key component in cancer progression. Initially, the primary roles assigned to MT1-MMP were the activation of proMMP-2 and degradation of fibrillar collagen ...
Anna M. Knapinska, Gregg B. Fields
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Screening MT1-MMP Activity and Inhibition in Three-Dimensional Tumor Spheroids [PDF]
Biomedicines, 2023 Membrane type 1 matrix metalloproteinase (MT1-MMP) has been shown to be crucial for tumor angiogenesis, invasion, and metastasis, and thus MT1-MMP is a high priority target for potential cancer therapies.
Anna M. Knapinska +9 more
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Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP, MMP14) in Eutopic and Ectopic Endometrium and in Serum and Endocervical Mucus of Endometriosis [PDF]
Biomedicines, 2023 Background: Membrane type-matrix metalloproteinases (MT-MMPs) are a subgroup of the matrix metalloproteinases (MMPs) family and are key molecules in the degradation of the extracellular matrix. Membrane type-1 matrix metalloproteinase (MT1-MMP, MMP14) is
Jane B. Maoga +7 more
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Identification of amino acid residues in the MT-loop of MT1-MMP critical for its ability to cleave low-density lipoprotein receptor [PDF]
Frontiers in Cardiovascular Medicine, 2022 Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol, preventing the development of atherosclerosis. We previously demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) cleaves LDLR and exacerbates the ...
Maggie Wang +10 more
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Analysis of the expression and prognostic value of MT1-MMP, β1-integrin and YAP1 in glioma [PDF]
Open Medicine, 2022 Increased expression of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) is associated with the development of many cancers. MT1-MMP may promote the entry of yes-associated protein1 (YAP1) into the nucleus by regulating the regulation of β1 ...
Zhai Yangyang +5 more
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TGF-β1 facilitates MT1-MMP-mediated proMMP-9 activation and invasion in oral squamous cell carcinoma cells [PDF]
Biochemistry and Biophysics Reports, 2021 Matrix metalloproteinase (MMP)-2 and MMP-9, also known as gelatinases or type IV collagenases, are recognized as major contributors to the proteolytic degradation of extracellular matrix during tumor invasion.
Hirari Yamahana +6 more
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