Results 91 to 100 of about 7,657 (149)

Novel Roles of MT1-MMP and MMP-2: Beyond the Extracellular Milieu. [PDF]

Int J Mol Sci, 2022
Maybee DV, Ink NL, Ali MAM.
europepmc   +1 more source

Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor. [PDF]

Nat Commun, 2022
Guo X, Asthana P, Gurung S, Zhang S, Wong SKK, Fallah S, Chow CFW, Che S, Zhai L, Wang Z, Ge X, Jiang Z, Wu J, Zhang Y, Wu X, Xu K, Lin CY, Kwan HY, Lyu A, Zhou Z, Bian ZX, Wong HLX.   +21 more
europepmc   +1 more source

VPS35/Retromer-dependent MT1-MMP regulation confers melanoma metastasis

Science China Life Sciences
AbstractRetromer is a conserved endosomal trafficking complex responsible for recycling transmembrane protein cargoes. Membrane-type I matrix metalloproteinase (MT1-MMP), a well-studied membrane-type metalloprotease, is highly expressed in metastatic melanomas.
Qinggang, Hao, Yan, Bai, Ruiqi, Guan, Rui, Dong, Weiyu, Bai, Hayam, Hamdy, Liqiong, Wang, Mingyao, Meng, Yan, Sun, Junling, Shen, Jianwei, Sun   +10 more
openaire   +2 more sources

MT1-mmp: a collagenase essential for tumor cell invasive growth.

Cancer cell, 2003
The manuscript discussed in this preview describes that reconstituted three-dimensional extracellular matrices such as fibrillar collagen and fibrin exert stringent territorial growth control on cells. The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1 ...
HOLMBECK K, BIANCO, Paolo, BIRKEDALHANSEN H.   +2 more
openaire   +2 more sources

Synthesis and In Vivo Evaluation of a Site-specifically Labeled Radioimmunoconjugate for Dual-Modal (PET/NIRF) Imaging of MT1-MMP in Sarcomas. [PDF]

Bioconjug Chem, 2022
Pringle TA, Chan CD, Luli S, Blair HJ, Rankin KS, Knight JC.   +5 more
europepmc   +1 more source

Effects of riboflavin/ultraviolet-A scleral collagen cross-linking on regional scleral thickness and expression of MMP-2 and MT1-MMP in myopic guinea pigs. [PDF]

PLoS One, 2023
Lv X, Lai L, Xu Y, Sun M, Li Y, Song Y, Wang N, Zhang F.   +7 more
europepmc   +1 more source

Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking. [PDF]

Mol Cancer Res, 2022
Brasher MI, Chafe SC, McDonald PC, Nemirovsky O, Gorshtein G, Gerbec ZJ, Brown WS, Grafinger OR, Marchment M, Matus E, Dedhar S, Coppolino MG.   +11 more
europepmc   +1 more source

Localisation of MT1-MMP to motility-associated structures

, 2010
MT1-MMP is a crucial enzyme for cellular invasion in tissues, and its polarised cell surface localisation is thought to be an important regulatory mechanism. In this thesis, the mechanisms regulating localisation of MT1-MMP to motility-associated structures were investigated. Using a series of MT1-MMP domain deletion mutants, it was found that an eight
Woskowicz, Anna, Woskowicz, Anna
openaire   +3 more sources

MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells. [PDF]

Int J Mol Sci, 2022
Pratt J, Haidara K, Annabi B.
europepmc   +1 more source

Exploring the Integrated Role of AKT2, CD44v6, And MT1-MMP as Predictors of Axillary Lymph Node Metastasis in Invasive Breast Carcinoma of No Special Type. [PDF]

Iran J Pathol, 2022
Rustamadji P, Wiyarta E, Bethania KA.
europepmc   +1 more source