Results 131 to 140 of about 7,657 (149)

MT1-MMP in human rheumatoid arthritis

, 2016
Miller, M, Manning, H, Jain, A, Troeberg, L, Dudhia, J, Essex, D, Sandison, A, Seiki, M, Nanchahal, J, Nagase, H, Itoh, Y   +10 more
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MT1-MMP modulates the mechanosensitivity of osteocytes

Biochemical and Biophysical Research Communications, 2012
Membrane-type matrix metalloproteinase-1 (MT1-MMP) is expressed by mechanosensitive osteocytes and affects bone mass. The extracellular domain of MT1-MMP is connected to extracellular matrix, while its intracellular domain is a strong modulator of cell signaling. In theory MT1-MMP could thus transduce mechanical stimuli into a chemical response.
Kulkarni, R.N., Bakker, A.D., Gruber, E.V., Chae, T.D., Veldkamp, J.B.B., Klein-Nulend, J., Everts, V.   +6 more
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MT1-MMP: Universal or particular player in angiogenesis?

Cancer and Metastasis Reviews, 2006
Tumorigenesis involves not only tumor cells that become transformed but also the peritumoral stroma which reacts inducing inflammatory and angiogenic responses. Angiogenesis, the formation of new capillaries from preexisting vessels, is an absolute requirement for tumor growth and metastasis, and it can be induced and modulated by a wide variety of ...
Laura, Genís, Beatriz G, Gálvez, Pilar, Gonzalo, Alicia G, Arroyo   +3 more
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Role of MT1-MMP in the osteogenic differentiation

Bone, 2009
Metalloproteinase MT1-MMP is induced and Pro-MMP-2 up modulated early in rat preosteoblasts (ROB) set to differentiate. We here show that the induction of MMPs, accompanied by activation of Pro-MMP-2, occurs by 6 h of adhesion on endogenous extracellular matrix (ECM), Fibronectin (FN) and Collagen type I (CI).
Manduca P, CASTAGNINO, ALESSIA, Lombardini D, Marchisio S, Soldano S, ULIVI, VALENTINA, Zanotti S, Garbi C, Ferrari N, PALMIERI, DANIELA   +9 more
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Investigation of MT1-MMP Activity in Cancer Cells

2023
Membrane-type 1 matrix metalloproteinase (MT1-MMP, also called MMP14) is one of the significant cell invasion drivers. MT1-MMP has been shown to play a crucial role in cancer invasion, cartilage degradation in rheumatoid arthritis, angiogenesis, and collagen homeostasis in different stromal tissues.
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Differential localization of MT1‐MMP in human prostate cancer tissue: Role of IGF‐1R in MT1‐MMP expression

The Prostate, 2008
AbstractBackgroundMT1‐MMP is a metalloproteinase involved in prostate cancer metastasis. The IGF‐1R is a tyrosine kinase receptor involved with tumor progression and metastasis. The purpose of this investigation was to examine MT1‐MMP and IGF‐1R expression and localization in prostate cancer tissues and explore the role of IGF‐1R in regulating MT1‐MMP ...
Isis C, Sroka, Kathy, McDaniel, Raymond B, Nagle, G Tim, Bowden   +3 more
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Abstract B07: Targeting an MT1-MMP/MMP2 axis in melanoma by a novel MT1-MMP/MMP2 inhibitor

Cancer Research, 2015
Abstract Metastatic melanoma remains the deadliest of all skin cancers with a survival rate at five years of less than 15%. Matrix metalloproteases (MMPs) are among the proteolytic enzymes responsible for the degradation/ digestion of the extracellular matrix (ECM) and have been associated with the aggressiveness of a ...
Khvaramze Shaverdashvili, Poki Wong, Jun Ma, Keman Zhang, Iman Osman, Barbara Bedogni   +5 more
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Need MT1-MMP? Just say NO!

Blood, 2007
In this issue of Blood, Genis and colleagues provide evidence for a dynamic interaction between membrane type 1–matrix metalloproteinase (MT1-MMP) and nitric oxide (NO) in migrating endothelial cells.
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The tetraspanin network modulates MT1-MMP cell surface trafficking

The International Journal of Biochemistry & Cell Biology, 2013
The membrane-type 1 matrix metalloproteinase (MT1-MMP) drives fundamental physiological and pathophysiological processes. Among other substrates, MT1-MMP cleaves components of the extracellular matrix and activates other matrix-cleaving proteases such as MMP-2.
H M, Schröder, S C, Hoffmann, M, Hecker, T, Korff, T, Ludwig   +4 more
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Loss of MT1-MMP affects CNS development

2013
Symposium in Honor of Patrick Tam FRS "60 Years & Still Gastrulating"
Zhou, Z, Zhou, J
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