Results 11 to 20 of about 7,657 (149)
The Diverse Pathways for Cell Surface MT1-MMP Localization in Migratory Cells [PDF]
CellsControlled cell migration is an essential biological process in health, while uncontrolled cell migration contributes to disease progression. For cells to migrate through tissue, they must first degrade the extracellular matrix (ECM), which acts as a ...
Hannah Kelly +2 more
doaj +2 more sources
MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity [PDF]
Cell DiscoveryObesity has been linked to an increased risk of cognitive impairment and dementia in later life. Although aging and obesity are both associated with cognitive decline, it remains unclear how they interact to affect cognitive function across the lifespan ...
Pallavi Asthana +22 more
doaj +2 more sources
Dynamic Expression of Membrane Type 1-Matrix Metalloproteinase (Mt1-mmp/Mmp14) in the Mouse Embryo [PDF]
Cells, 2021 MT1-MMP/MMP14 belongs to a subgroup of the matrix metalloproteinases family that presents a transmembrane domain, with a cytosolic tail and the catalytic site exposed to the extracellular space.
Emma Muñoz-Sáez +4 more
doaj +2 more sources
Cytoplasmic Tail of MT1-MMP: A Hub of MT1-MMP Regulation and Function. [PDF]
Int J Mol Sci, 2023 MT1-MMP (MMP-14) is a multifunctional protease that regulates ECM degradation, activation of other proteases, and a variety of cellular processes, including migration and viability in physiological and pathological contexts. Both the localization and signal transduction capabilities of MT1-MMP are dependent on its cytoplasmic domain that constitutes ...
Strouhalova K +3 more
europepmc +4 more sources
MT1-MMP recruits the ER-Golgi SNARE Bet1 for efficient MT1-MMP transport to the plasma membrane. [PDF]
J Cell Biol, 2019 Metastasis is a major cause of cancer-related death. Membrane type 1–matrix metalloproteinase (MT1-MMP) is a critical protease for local invasion and metastasis. MT1-MMP is synthesized in the endoplasmic reticulum (ER) and transported in vesicles to invadopodia, specialized subdomains of the plasma membrane, through secretory and endocytic recycling ...
Miyagawa T +11 more
europepmc +4 more sources
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
MT1‐MMP: A tethered collagenase [PDF]
Journal of Cellular Physiology, 2004 AbstractGene ablation in mice offers a powerful tool to assay in vivo the role of selected molecules. Numerous new mouse models of matrix metalloproteinases (MMP) deficiency have been developed in the past 5 years and have yielded a new understanding of the role of MMPs while also putting to rest assumptions based on data predating the days of mouse ...
Kenn Holmbeck +3 more
openaire +3 more sources
When MT1-MMP meets ADAMs [PDF]
Cell Cycle, 2012 MT1-MMP is a membrane-tethered enzyme capable of remodeling extracellular matrix. MT1-MMP-deficient mice exhibit systematic defects during development, especially in craniofacial development characterized by retarded calvarial bone formation. Recently, we identified MT1-MMP as a critical positive modulator of FGF signaling during intramembranous ...
Zhou, Z +5 more
openaire +4 more sources
Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia. [PDF]
PLoS Computational Biology, 2013 Focal degradation of extracellular matrix (ECM) is the first step in the invasion of cancer cells. MT1-MMP is a potent membrane proteinase employed by aggressive cancer cells.
Ayako Watanabe +5 more
doaj +1 more source