Results 21 to 30 of about 7,657 (149)

Membrane-type-3 matrix metalloproteinase (MT3-MMP) functions as a matrix composition-dependent effector of melanoma cell invasion. [PDF]

PLoS ONE, 2011
In primary human melanoma, the membrane-type matrix metalloproteinase, MT3-MMP, is overexpressed in the most aggressive nodular-type tumors. Unlike MT1-MMP and MT2-MMP, which promote cell invasion through basement membranes and collagen type I-rich ...
Olga Tatti, Mariliina Arjama, Annamari Ranki, Stephen J Weiss, Jorma Keski-Oja, Kaisa Lehti   +5 more
doaj   +1 more source

Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity. [PDF]

PLoS ONE, 2013
Matrix metalloproteinase (MMP)-dependent extracellular matrix (ECM) remodeling is a key feature in cardiometabolic syndrome-associated adipogenesis and atherosclerosis. Activation of membrane-tethered (MT) 1-MMP depends on furin (PCSK3).
Kai Kappert, Heike Meyborg, Jan Fritzsche, Daniel Urban, Janine Krüger, Ernst Wellnhofer, Ulrich Kintscher, Eckart Fleck, Philipp Stawowy   +8 more
doaj   +1 more source

Modulation of RECK levels in Xenopus A6 cells: effects on MT1-MMP, MMP-2 and pERK levels

Journal of Biological Research - Thessaloniki, 2019
Background MT1-MMP is a cell-surface enzyme whose regulation of pro-MMP-2 and ERK activation position it as a key facilitator of ECM remodelling and cell migration.
Jessica A. Willson, Bradley S. Bork, Carlie A. Muir, Sashko Damjanovski   +3 more
doaj   +1 more source

HPV16 oncoproteins promote cervical cancer invasiveness by upregulating specific matrix metalloproteinases. [PDF]

PLoS ONE, 2013
Production of matrix metalloproteinases (MMPs) for degradation of extracellular matrix is a vital step in cancer metastasis. We investigated the effects of HPV16 oncoproteins (16E6, 16E6*I and 16E7), either individually or combined, on the transcription ...
Jittranan Kaewprag, Wareerat Umnajvijit, Jarunya Ngamkham, Mathurose Ponglikitmongkol   +3 more
doaj   +1 more source

MT1-MMP

Communicative & Integrative Biology, 2010
Mice deficient in the matrix metalloproteinase MT1-MMP display defects in tissue development and angiogenesis, together with a complex bone phenotype characterized by several skeletal abnormalities and osteopenia. OCs and giant cells are multinucleated cells arising from the fusion of myeloid progenitors/macrophages that specialize respectively in bone
Pilar, Gonzalo, Alicia G, Arroyo
openaire   +2 more sources

Inhibition of β1 integrin induces its association with MT1-MMP and decreases MT1-MMP internalization and cellular invasiveness

Cellular Signalling, 2021
Integrin signaling plays a fundamental role in the establishment of focal adhesions and the subsequent formation of invadopodia in malignant cancer cells. Invadopodia facilitate localized adhesion and degradation of the extracellular matrix (ECM), which promote tumour cell invasion and metastasis.
Olivia R, Grafinger, Genya, Gorshtein, Tyler, Stirling, Jennifer, Geddes-McAlister, Marc G, Coppolino   +4 more
openaire   +2 more sources

MT1‐MMP: A potent modifier of pericellular microenvironment [PDF]

Journal of Cellular Physiology, 2005
AbstractCells are regulated by many different means, and there is more and more evidence emerging that changes in the microenvironment greatly affect cell function. MT1‐MMP is a type I transmembrane proteinase which participates in pericellular proteolysis of extracellular matrix (ECM) macromolecules.
Itoh, Y, Seiki, M
openaire   +3 more sources

Targeting a Designer TIMP-1 to the Cell Surface for Effective MT1-MMP Inhibition: A Potential Role for the Prion Protein in Renal Carcinoma Therapy

Molecules, 2019
Renal carcinoma cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP, MMP-14) to degrade extracellular matrix components and a range of bioactive molecules to allow metastasis and cell proliferation. The activity of MT1-MMP is modulated by the
Bingjie Jiang, Jian Liu, Meng Huee Lee
doaj   +1 more source

Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking. [PDF]

PLoS ONE, 2012
Emerging evidence has implicated the role of tumor initiating cells (TICs) in the process of cancer metastasis. The mechanism underlying the conversion of TICs from stationary to invasive remains to be characterized.
Jian Li, Stanley Zucker, Ashleigh Pulkoski-Gross, Cem Kuscu, Mihriban Karaayvaz, Jingfang Ju, Herui Yao, Erwei Song, Jian Cao   +8 more
doaj   +1 more source

Site-specific cellular functions of MT1-MMP

European Journal of Cell Biology, 2012
The response to environmental cues such as inflammatory stimuli requires coordinated cellular functions. Certain proteins have functions on both sides of the plasma membrane to allow coordination between the extracellular and intracellular milieus.
Agnieszka, Koziol, Mara, Martín-Alonso, Cristina, Clemente, Pilar, Gonzalo, Alicia G, Arroyo   +4 more
openaire   +2 more sources