Results 31 to 40 of about 7,657 (149)
CD44 Regulates Pancreatic Cancer Invasion through MT1-MMP [PDF]
Molecular Cancer Research, 2015 Abstract Pancreatic cancer is one of the deadliest human malignancies due to its early metastatic spread and resistance to therapy. The mechanisms regulating pancreatic cancer metastasis are so far poorly understood. Here, using both in vitro and in vivo approaches, it is demonstrated that CD44, a transmembrane glycoprotein expressed ...
Wei, Jiang +6 more
openaire +2 more sources
MT1-MMP: an enzyme with multidimensional regulation
Trends in Biochemical Sciences, 2004 The activity of membrane-type 1 matrix metalloproteinase (MT1-MMP) is a double-edged sword--it is crucial for both physiological processes and disease progression. MT1-MMP modifies various cellular functions and it is, sthus, regulated precisely as a proteinase and as a membrane protein. Recent studies have further revealed that the function of MT1-MMP
Itoh, Y, Seiki, M
openaire +3 more sources
Membrane-type 1 Matrix Metalloproteinase Modulates Tissue Homeostasis by a Non-proteolytic Mechanism
iScience, 2020 Summary: Membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14), a transmembrane proteinase with a short cytoplasmic tail, is a major effector of extracellular matrix remodeling.
Mukundan Attur +14 more
doaj +1 more source
Qualitative and Quantitative Analysis of Tumor Cell Invasion Using Au Clusters
Nanomaterials, 2021 Tumor invasion/metastasis is still the major cause of death in cancer patients. Membrane type-1 matrix metalloproteinase (MT1-MMP) is directly related to tumor invasion/metastasis.
Xiangchun Zhang +10 more
doaj +1 more source
TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis. [PDF]
PLoS ONE, 2015 Membrane-type 1 matrix metalloproteinase (MT1-MMP), a transmembrane proteinase with an extracellular catalytic domain and a short cytoplasmic tail, degrades a variety of extracellular matrix (ECM) components.
Cristina Valacca +2 more
doaj +1 more source
MT1-MMP-Mediated Cleavage of Decorin in Corneal Angiogenesis [PDF]
Journal of Vascular Research, 2009 <i>Background/Aims:</i> Decorin has been shown to have antiangiogenic properties. In this study, we evaluate the involvement of membrane type 1-matrix metalloproteinase (MT1-MMP), a proangiogenic enzyme, in decorin cleavage in the cornea. <i>Methods:</i> MT1-MMP expression was confirmed immunohistochemically in keratocytes and ...
Kojima, T +7 more
openaire +4 more sources
Diffusion of MMPs on the surface of collagen fibrils: the mobile cell surface-collagen substratum interface. [PDF]
PLoS ONE, 2011 Remodeling of the extracellular matrix catalyzed by MMPs is central to morphogenetic phenomena during development and wound healing as well as in numerous pathologic conditions such as fibrosis and cancer.
Ivan E Collier +7 more
doaj +1 more source
Oncotarget, 2015 Metastatic melanoma is the deadliest of all skin cancers. Despite progress in diagnostics and treatment of melanoma, the prognosis for metastatic patients remains poor. We previously showed that Membrane-type 1 Matrix Metalloproteinase (MT1-MMP) is one of the drivers of melanoma metastasis.
Khvaramze, Shaverdashvili +5 more
openaire +3 more sources
Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas. [PDF]
PLoS ONE, 2016 A critical challenge in the management of Glioblastoma Multiforme (GBM) tumors is the accurate diagnosis and assessment of tumor progression in a noninvasive manner.
A G de Lucas +10 more
doaj +1 more source
Quantitative FRET imaging to visualize the invasiveness of live breast cancer cells. [PDF]
PLoS ONE, 2013 Matrix metalloproteinases (MMPs) remodel tumor microenvironment and promote cancer metastasis. Among the MMP family proteases, the proteolytic activity of the pro-tumorigenic and pro-metastatic membrane-type 1 (MT1)-MMP constitutes a promising and ...
Shaoying Lu +8 more
doaj +1 more source