Results 81 to 90 of about 7,657 (149)

How the Fibrotic Lung Microenvironment Regulates Stem Cell Behavior: Immune Cues, Extracellular Matrix Remodeling, and Therapeutic Implications

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Pulmonary fibrosis (PF) is a chronic and progressive interstitial lung disease characterized by excessive extracellular matrix (ECM) deposition and remodeling of lung structures. Currently, no effective clinical treatments exist to reverse or halt the progression of PF.
Zihan Zhou, Shuhua Han, Yuanfang Duan, Minqi Hong, Jie Huang, Andrey Elchaninov   +5 more
wiley   +1 more source

Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling

Molecular Cancer, 2006
Background Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are bioactive lipid signaling molecules implicated in tumor dissemination.
Anthis Nicholas J, Koh Wonshill, Pop Andreia, Fisher Kevin E, Saunders W Brian, Davis George E   +5 more
doaj   +1 more source

Prognostic Value of Membrane Type 1 and 2 Matrix Metalloproteinase Expression and Gelatinase a Activity in Bladder Cancer

The International Journal of Biological Markers, 2010
Purpose To analyze the behavior of matrix metalloproteinases (MMPs) in their active state in patients with bladder cancer. Method A retrospective study of 50 patients with localized bladder cancer who underwent tumor resection between June 2006 and June ...
Mohammad A. Mohammad, Naglaa R. Ismael, Sabry M. Shaarawy, Mahmoud M. El-Merzabani   +3 more
doaj   +1 more source

Membrane Type 1 Matrix Metalloprotease Cleaves Laminin-10 and Promotes Prostate Cancer Cell Migration

Neoplasia: An International Journal for Oncology Research, 2005
Disruption of the extracellular matrix by proteases is crucial for tumor invasion. Laminin-10 (Ln-10) has previously been identified as a substrate for cell migration and cell adhesion, and is present in the basal lamina (BL) of both normal prostate and ...
Elisabeth L. Bair, Man Ling Chen, Kathy McDaniel, Kiyotoshi Sekiguchi, Anne E. Cress, Raymond B. Nagle, George Timothy Bowden   +6 more
doaj   +1 more source

A MT1-MMP/NF-κB signaling axis as a checkpoint controller of COX-2 expression in CD133(+) U87 glioblastoma cells

Journal of Neuroinflammation, 2009
Background The CD133(+) stem cell population in recurrent gliomas is associated with clinical features such as therapy resistance, blood-brain barrier disruption and, hence, tumor infiltration.
Annabi Borhane, Laflamme Carl, Sina Asmaa, Lachambre Marie-Paule, Béliveau Richard   +4 more
doaj   +1 more source

Membrane‐Tethered Metalloproteinase Expressed by Vascular Smooth Muscle Cells Limits the Progression of Proliferative Atherosclerotic Lesions

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe MMP (matrix metalloproteinase) family plays diverse and critical roles in directing vascular wall remodeling in atherosclerosis. Unlike secreted‐type MMPs, a member of the membrane‐type MMP family, MT1‐MMP (membrane‐type 1 MMP; MMP14 ...
Richard H. Barnes, Takeshi Akama, Miina K. Öhman, Moon‐Sook Woo, Julian Bahr, Stephen J. Weiss, Daniel T. Eitzman, Tae‐Hwa Chun   +7 more
doaj   +1 more source

Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo

BMC Cancer, 2006
Background Identification of fibroblast derived factors in tumor progression has the potential to provide novel molecular targets for modulating tumor cell growth and metastasis.
Vick Catherine C, Holmbeck Kenn, Matrisian Lynn M, Zhang Wenyue, Rosenthal Eben L   +4 more
doaj   +1 more source

KIF16B drives MT1-MMP recycling in macrophages and promotes co-invasion of cancer cells. [PDF]

Life Sci Alliance, 2023
Hey S, Wiesner C, Barcelona B, Linder S.
europepmc   +1 more source

Hematopoietic Stem Cell Mobilization and Homing after Transplantation: The Role of MMP-2, MMP-9, and MT1-MMP

Biochemistry Research International, 2012
Hematopoietic stem/progenitor cells (HSPCs) are used in clinical transplantation to restore hematopoietic function. Here we review the role of the soluble matrix metalloproteinases MMP-2 and MMP-9, and membrane type (MT)1-MMP in modulating processes ...
Neeta Shirvaikar, Leah A. Marquez-Curtis, Anna Janowska-Wieczorek   +2 more
doaj   +1 more source

Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2. [PDF]

Nat Commun, 2022
Guo X, Cao J, Cai JP, Wu J, Huang J, Asthana P, Wong SKK, Ye ZW, Gurung S, Zhang Y, Wang S, Wang Z, Ge X, Kwan HY, Lyu A, Chan KM, Wong N, Huang J, Zhou Z, Bian ZX, Yuan S, Wong HLX.   +21 more
europepmc   +1 more source