Results 11 to 20 of about 20,657 (172)
Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
Frontiers in Cardiovascular Medicine, 2022 Low-density lipoprotein receptor (LDLR) mediates clearance of plasma LDL cholesterol, preventing the development of atherosclerosis. We previously demonstrated that membrane type 1-matrix metalloproteinase (MT1-MMP) cleaves LDLR and exacerbates the ...
Maggie Wang +10 more
doaj +1 more source
Screening MT1-MMP Activity and Inhibition in Three-Dimensional Tumor Spheroids
Biomedicines, 2023 Membrane type 1 matrix metalloproteinase (MT1-MMP) has been shown to be crucial for tumor angiogenesis, invasion, and metastasis, and thus MT1-MMP is a high priority target for potential cancer therapies.
Anna M. Knapinska +9 more
doaj +1 more source
When MT1-MMP meets ADAMs [PDF]
Cell Cycle, 2012 MT1-MMP is a membrane-tethered enzyme capable of remodeling extracellular matrix. MT1-MMP-deficient mice exhibit systematic defects during development, especially in craniofacial development characterized by retarded calvarial bone formation. Recently, we identified MT1-MMP as a critical positive modulator of FGF signaling during intramembranous ...
Zhou, Z +5 more
openaire +4 more sources
Critical role of transient activity of MT1-MMP for ECM degradation in invadopodia. [PDF]
PLoS Computational Biology, 2013 Focal degradation of extracellular matrix (ECM) is the first step in the invasion of cancer cells. MT1-MMP is a potent membrane proteinase employed by aggressive cancer cells.
Ayako Watanabe +5 more
doaj +1 more source
Biomedicines, 2023 Background: Membrane type-matrix metalloproteinases (MT-MMPs) are a subgroup of the matrix metalloproteinases (MMPs) family and are key molecules in the degradation of the extracellular matrix. Membrane type-1 matrix metalloproteinase (MT1-MMP, MMP14) is
Jane B. Maoga +7 more
doaj +1 more source
Regulation of MT1-MMP Activity through Its Association with ERMs
Cells, 2020 Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development.
Henar Suárez +7 more
doaj +1 more source
Analysis of the expression and prognostic value of MT1-MMP, β1-integrin and YAP1 in glioma
Open Medicine, 2022 Increased expression of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14) is associated with the development of many cancers. MT1-MMP may promote the entry of yes-associated protein1 (YAP1) into the nucleus by regulating the regulation of β1 ...
Zhai Yangyang +5 more
doaj +1 more source
Molecules, 2022 Ovarian cancer (OC) is the most lethal gynecologic malignancy, and melatonin has shown various antitumor properties. Herein, we investigated the influence of melatonin therapy on energy metabolism and mitochondrial integrity in SKOV-3 cells and tested ...
Maira Smaniotto Cucielo +8 more
doaj +1 more source
The Expanding Role of MT1-MMP in Cancer Progression
Pharmaceuticals, 2019 For over 20 years, membrane type 1 matrix metalloproteinase (MT1-MMP) has been recognized as a key component in cancer progression. Initially, the primary roles assigned to MT1-MMP were the activation of proMMP-2 and degradation of fibrillar collagen ...
Anna M. Knapinska, Gregg B. Fields
doaj +1 more source