Results 21 to 30 of about 20,657 (172)
Conversion of stationary to invasive tumor initiating cells (TICs): role of hypoxia in membrane type 1-matrix metalloproteinase (MT1-MMP) trafficking. [PDF]
PLoS ONE, 2012 Emerging evidence has implicated the role of tumor initiating cells (TICs) in the process of cancer metastasis. The mechanism underlying the conversion of TICs from stationary to invasive remains to be characterized.
Jian Li +8 more
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Biotechnology & Biotechnological Equipment, 2019 Melatonin (MEL) may influence the efficiency of reprogramming both by somatic cell nuclear transfer and by direct induction of pluripotent stem cells (iPSC) through a yet unidentified mechanism. Transcription factors linked to cell reprogramming and cell
Georgi Nikolaev Georgiev +3 more
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Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep
Frontiers in Endocrinology, 2019 The pathophysiological function of the G-protein coupled melatonin MT1 and MT2 receptors has not yet been well-clarified. Recent advancements using selective MT1/ MT2 receptor ligands and MT1/MT2 receptor knockout mice have suggested that the activation ...
Gabriella Gobbi +2 more
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Qualitative and Quantitative Analysis of Tumor Cell Invasion Using Au Clusters
Nanomaterials, 2021 Tumor invasion/metastasis is still the major cause of death in cancer patients. Membrane type-1 matrix metalloproteinase (MT1-MMP) is directly related to tumor invasion/metastasis.
Xiangchun Zhang +10 more
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Proprotein convertase subtilisin/kexin type 3 promotes adipose tissue-driven macrophage chemotaxis and is increased in obesity. [PDF]
PLoS ONE, 2013 Matrix metalloproteinase (MMP)-dependent extracellular matrix (ECM) remodeling is a key feature in cardiometabolic syndrome-associated adipogenesis and atherosclerosis. Activation of membrane-tethered (MT) 1-MMP depends on furin (PCSK3).
Kai Kappert +8 more
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The Regulatory Mechanism of MLT/MT1 Signaling on the Growth of Antler Mesenchymal Cells
Molecules, 2017 Melatonin (MLT) plays an important role in regulating the physiological cycle of seasonal breeding animals. Melatonin receptor I (MT1) is effectively expressed in the cambium layer of deer antler.
Feifei Yang +8 more
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TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis. [PDF]
PLoS ONE, 2015 Membrane-type 1 matrix metalloproteinase (MT1-MMP), a transmembrane proteinase with an extracellular catalytic domain and a short cytoplasmic tail, degrades a variety of extracellular matrix (ECM) components.
Cristina Valacca +2 more
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Targeting MT1-MMP as an ImmunoPET-Based Strategy for Imaging Gliomas. [PDF]
PLoS ONE, 2016 A critical challenge in the management of Glioblastoma Multiforme (GBM) tumors is the accurate diagnosis and assessment of tumor progression in a noninvasive manner.
A G de Lucas +10 more
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Molecules, 2019 Renal carcinoma cells express Membrane Type 1-Matrix Metalloproteinase (MT1-MMP, MMP-14) to degrade extracellular matrix components and a range of bioactive molecules to allow metastasis and cell proliferation. The activity of MT1-MMP is modulated by the
Bingjie Jiang, Jian Liu, Meng Huee Lee
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Communicative & Integrative Biology, 2010 Mice deficient in the matrix metalloproteinase MT1-MMP display defects in tissue development and angiogenesis, together with a complex bone phenotype characterized by several skeletal abnormalities and osteopenia. OCs and giant cells are multinucleated cells arising from the fusion of myeloid progenitors/macrophages that specialize respectively in bone
Pilar, Gonzalo, Alicia G, Arroyo
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