Results 121 to 130 of about 179,868 (286)

The Tumor Metabolite 5′-Deoxy-5′Methylthioadenosine (MTA) Inhibits Maturation and T Cell-Stimulating Capacity of Dendritic Cells

open access: yesCells
Metabolite accumulation in the tumor microenvironment fosters immune evasion and limits the efficiency of immunotherapeutic approaches. Methylthioadenosine phosphorylase (MTAP), which catalyzes the degradation of 5′-deoxy-5′methylthioadenosine (MTA), is ...
Christina Brummer   +11 more
doaj   +1 more source

Prognostic Value of Parkinson's Disease Subtypes in the LABS‐PD Cohort: Functional Ability, Quality of Life and Mortality

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Research on Parkinson's disease (PD) heterogeneity may inform clinical prognosis. There is currently no fully validated PD subtype classification system. Objectives We aimed at assessing the prognostic relevance of a data‐driven PD subtype classification system.
Deepa Dash   +7 more
wiley   +1 more source

Results of tests of MTA-2 TPS on the SRB hold-down bolt blast container [PDF]

open access: yes
The four solid rocket booster (SRB) hold-down posts are fastened to the mobile launch platform (MLP) with four large nuts. At liftoff the nuts are split with explosive changes to release the SRB/Shuttle.
Dean, W. G.
core   +1 more source

One Last Chance: The Economic Case for a New Approach to Fisheries Management in New England [PDF]

open access: yes, 2009
Documents the decline of the New England fishing industry as a result of mismanagement, presents examples of successful and sustainable fisheries, and examines the viability of proposed community-based, fishermen-run cooperatives as a ...
Jon G. Sutinen, Robert J. Johnston
core  

Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Clinical outcome assessments (COAs) are essential for evaluating symptom severity, treatment response, and disease progression in Parkinson's disease (PD). As clinical knowledge evolves, it is necessary to revisit the recommendation status on the COAs to ensure their continued relevance and validity. Objectives To provide an updated
Evita Papathoma   +14 more
wiley   +1 more source

An In-Vitro Comparative Evaluation of Sealing Ability and Adaptation of Gel Form of MTA to Dentinal Walls: An Original Study

open access: yesJournal of Pharmacy and Bioallied Sciences
Background: Mineral Trioxide Aggregate (MTA) is widely used in endodontics due to its biocompatibility and sealing properties. The gel form of MTA has been introduced to enhance handling and adaptation characteristics.
Priyatam M. Karade   +6 more
doaj   +1 more source

Feasibility of Simon Two‐Stage Futility Trials in People with Early, Symptomatically Treated Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Disease‐modifying treatments are a critical unmet need in Parkinson's disease (PD). Phase 2 futility trials using the Simon two‐stage design offer an efficient strategy to evaluate candidate treatments in an early PD population. Objective The aim was to assess the feasibility of Simon two‐stage futility trials in early, levodopa ...
Marcus W. Koch   +12 more
wiley   +1 more source

Dislodgement resistance and structural changes of tricalcium silicate-based cements after exposure to different chelating agents.

open access: yesPLoS ONE
This study aimed to evaluate the dislodgement resistance and structural changes of different mineral trioxide aggregate cements (MTA) like Pro-Root MTA, Ortho MTA, and Retro MTA after exposure to sodium hypochlorite (NaOCl), NaOCl ...
Özgür İlke Ulusoy   +5 more
doaj   +1 more source

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