Results 241 to 250 of about 202,264 (382)

The anti‐fibrotic effects of novel heart failure pharmacotherapies in advanced heart failure patients

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Novel heart failure (HF) pharmacotherapies, including angiotensin receptor‐neprilysin inhibitor (ARNI) and sodium‐glucose cotransporter 2 inhibitors (SGLT2is), may confer cardiovascular benefits by attenuating myocardial fibrosis. However, direct evidence from human failing myocardial samples is limited.
Dávid Nagy   +10 more
wiley   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind   +6 more
wiley   +1 more source

Global overview of progress in respecting the contributions of traditional knowledge in biodiversity governance

open access: yesConservation Biology, EarlyView.
Abstract Recognition and engagement of Indigenous Peoples and local communities (IP&LCs) and other traditional knowledge (TK) holders in formal biodiversity governance remain limited, despite their significant contribution to the conservation and sustainable use of biodiversity through their knowledge, innovations, practices, and land stewardship.
Kinga Öllerer   +8 more
wiley   +1 more source

Osseous reaction to implantation of two endodontic cements: Mineral trioxide aggregate (MTA) and calcium enriched mixture (CEM)

open access: bronze, 2012
Saeed Rahimi   +7 more
openalex   +1 more source

Making Advanced Therapies Affordable and Accessible: Two Strategic Approaches

open access: yesDeveloping World Bioethics, EarlyView.
ABSTRACT This article explores two complementary strategies for addressing the affordability and access challenges facing advanced therapies. As high development costs and limited market access have led to the withdrawal of several therapies, the article examines how these barriers create ‘valleys of death’ that prevent innovation from reaching ...
Ubaka Ogbogu, Lauren Albrecht
wiley   +1 more source

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells. [PDF]

open access: yesNat Commun
Rothweiler EM   +18 more
europepmc   +1 more source

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