Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications
Advanced Science, EarlyView.Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo +12 more
wiley +1 more source
Advanced Science, EarlyView.Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao +36 more
wiley +1 more source
Endodontic treatment of immature tooth – a challenge
Journal of Pre-Clinical and Clinical Research, 2020 Root apex is an area of primary importance for an endodontist. When a tooth erupts in the oral cavity the apical foramen undergoes anatomical changes with age.
Sonu Gupta +3 more
doaj +1 more source
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology
Advanced Science, EarlyView.Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto +11 more
wiley +1 more source
Bulletin of the Mineral Research and Exploration, 1951 L e gisement se trouve entre les altitudes de 1900 à 2020. Il est entouré presque de tous côtés par les éboulis qui empêhent de voir sa position stratigraphique et tectonique avec le terrain avoisinant. Cependant quelques parties du gisement peuvent être
MTA .
doaj
Supplementary Figure S7 from MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with <i>MTAP</i>-Deleted Cancer [PDF]
, 2023 Lars D. Engstrom +31 more
openalex +1 more source
Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay
Advanced Science, EarlyView.This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao +6 more
wiley +1 more source
Etude Mineralogique Et Petrographique Du Mineral De Fer De La Mine De Chamosenze
Bulletin of the Mineral Research and Exploration, 1951 -
MTA ...
doaj
Radiation shielding calculations for MuCool Test Area at Fermilab
, 2004 The MuCool Test Area (MTA) is an intense primary beam facility derived directly from the Fermilab Linac to test heat deposition and other technical concerns associated with the liquid hydrogen targets being developed for cooling intense muon beams.
Johnstone, C., Rakhno, I.
core +2 more sources
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source