Results 111 to 120 of about 105,969 (277)

Degradable Nanocarriers Capable of Gene Delivery Derived from pH‐Responsive Polyester: RROP Copolymerization Between Cyclic Ketene Acetals

open access: yesMacromolecular Rapid Communications, EarlyView.
Polyesters with inherent pH‐sensitivity are prepared through radical ring‐opening polymerization between cyclic ketene acetals. These polyesters demonstrate great potential as alternatives to conventional polycations for fabricating hybrid nanoparticles.
Yiyi Deng   +3 more
wiley   +1 more source

Achieving the Rio target: CO2 abatement through fiscal policy in the UK [PDF]

open access: yes
The research reported in this paper is an application of a large energy-environment-economy model2 of the UK to the medium-term issue of stabilising carbon dioxide (CO2) emissions at their 1990 levels by the year 2000, a commitment by the UK government ...
Clare Bryden, Susan Baylis, Terry Barker
core  

Aliphatic Poly(Carbonate)s with Acid Responsive Release Mechanisms for Micellar Anti‐Tumor Drug Delivery

open access: yesMacromolecular Rapid Communications, EarlyView.
Micellar systems based on biodegradable aliphatic polycarbonates and acid‐responsive triggers enhance drug solubility, stability, and tumor‐selective release. This review covers micelles with acid‐cleavable drug linkages and those that disassemble via acid‐sensitive functionalities.
Adrian V. Hauck, Lutz Nuhn
wiley   +1 more source

Molecular Diagnostics in Thyroid Nodules: Current Applications, Clinical Value, and Future Perspective

open access: yesMed Research, EarlyView.
ABSTRACT Molecular diagnostics have become an important adjunct to ultrasonography and fine‐needle aspiration (FNA) for thyroid nodules, especially in Bethesda III/IV cytology where malignancy risk is uncertain. This narrative review summarizes the diagnostic and prognostic value of key genomic drivers (BRAF V600E, RAS, RET, TERT, and selected fusions)
Guohui Xiao   +14 more
wiley   +1 more source

Correction: Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells

open access: yesCell Death Discovery, 2022
Twana Alkasalias   +9 more
doaj   +1 more source

Beyond 5G and Non‐terrestrial Network (NTN) Integrated Architecture: Access Challenges for Expanding Artificial Intelligence of Things (AIoT)

open access: yesInternational Journal of Satellite Communications and Networking, EarlyView.
ABSTRACT This study analyzes the architecture of the beyond 5G‐NTN (Non‐terrestrial Network) integrated network and presents the technical, legal, and regulatory challenges and considerations for expanding the Artificial Intelligence of Things (AIoT) ecosystem.
Byung Woon Kim, Ga Eun Choi
wiley   +1 more source

Teachers' Pedagogical Reasoning and Students' Three‐Dimensional Learning

open access: yesScience Education, EarlyView.
ABSTRACT This article reports analyses of data from a design‐based implementation project focused on middle‐ and high‐school science teaching. Drawing on teacher interviews and surveys as well as student learning evidence, we examined the relationships between teachers' pedagogical reasoning and their students' three‐dimensional learning. Most teachers
Christie Morrison Thomas   +5 more
wiley   +1 more source

Structural insights into the binding mode of the hypnotic drug vornorexant to orexin receptors

open access: yesActa Crystallographica Section F, EarlyView.
The crystal structure of the human orexin type 2 receptor–vornorexant complex (3.29 Å resolution) and orexin type 1 receptor docking revealed a conserved U‐shaped binding conformation, explaining the high affinity and balanced dual antagonism of this dual orexin receptor antagonist. The structural data validate the rational design that incorporated a 1,
Masashi Mima   +4 more
wiley   +1 more source

Long-term survival outcomes of systemic therapy in patients with isolated and mixed medullary thyroid cancer

open access: yesHeliyon
Background: Medullary thyroid carcinoma (MTC) is an uncommon thyroid cancer with limited treatment options for advanced disease. A small subset exhibits mixed MTC histology with both medullary and well-differentiated components.
Manal S. Fawzy   +3 more
doaj   +1 more source

The Price Gap in Agriculture‐Based Greenhouse Gas Offset Markets

open access: yesAustralian Journal of Agricultural and Resource Economics, EarlyView.
ABSTRACT Today, there is a global effort to reduce greenhouse gas net emissions (GHGNE). For economic well‐being, it is important to identify low‐cost means of net emission offsets. Agriculture and forestry have received considerable attention as a means of supplying emissions offsets, as they contribute nearly 20% of global emissions.
Jingyi W. Liu   +2 more
wiley   +1 more source

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