Results 131 to 140 of about 105,969 (277)

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

Clinicopathological features and outcomes in patients with concurrent medullary and papillary thyroid carcinoma

Frontiers in Endocrinology
ObjectiveThe co-existence of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) is rare. The study analyzed the clinicopathological findings and prognosis of concomitant PTC in MTC patients.MethodsClinicopathological data and follow ...
Ruonan Sun, Ruonan Sun, Xueting Liu, Jiabin Liu, Jiabin Liu, Zhihui Li, Zhihui Li, Yichao Wang, Yichao Wang   +8 more
doaj   +1 more source

Load‐To‐Failure of Cantilevered Provisional Implant‐Supported Prostheses: Conventional Versus 3D‐Printed Resins

Journal of Esthetic and Restorative Dentistry, EarlyView.
ABSTRACT Objective Cantilever extensions in full‐arch implant‐supported provisional prostheses represent a clinical challenge frequently associated with biomechanical complications. This study aimed to evaluate the load‐to‐failure and deflection of acrylic and 3D‐printed resins used in the cantilever region of implant‐supported provisional prostheses ...
Térsia Cristina Silva Macedo, Carolina Neves Tannous Dib, Maribi Isomar Terán Lozada, João Pedro Alves Silva, Karla Zancopé   +4 more
wiley   +1 more source

First direct evidence of spawning by Japanese sardine Sardinops melanosticta (Temminck and Schlegel) in the eastern Pacific Ocean

Journal of Fish Biology, EarlyView.
Abstract In 2022 the presence of the Japanese sardine, Sardinops melanosticta (Temminck and Schlegel), was detected in the eastern Pacific Ocean, far outside its known western North Pacific range. The species was collected along with the Pacific sardine, Sardinops sagax (Jenyns), which is native to the eastern Pacific Ocean.
Miasara Andrew, Toby D. Auth, Kym C. Jacobson, Matthew T. Craig   +3 more
wiley   +1 more source

Enhanced CO2 Coordinates the Spatial Recruitment of Diazotrophs in Rice Via Root Development

Plant, Cell &Environment, EarlyView.
ABSTRACT Understanding the reciprocal interaction between root development and coadapted beneficial microbes in response to elevated CO2 (eCO2) will facilitate the identification of nutrient‐efficient cultivars for sustainable agriculture. Here, systematic morphological, anatomical, chemical and gene expression assays performed under low‐nitrogen ...
Junwen Zhao, Yuting Chen, Qi Tao, Lukas Schreiber, Kiran Suresh, Michael Frei, Muhammad Shahedul Alam, Bing Li, Yaping Zhou, Marcel Baer, Frank Hochholdinger, Changquan Wang, Peng Yu   +12 more
wiley   +1 more source

Impaired hematopoiesis affects apheresis and CAR T‐cell product composition and treatment response

Transfusion, EarlyView.
Abstract Background Chimeric antigen receptor (CAR) T‐cell therapy has transformed the treatment of hematologic malignancies, but its success depends on obtaining sufficient CD3+ T‐cell yields during leukapheresis. This can be difficult in heavily pretreated patients, who often show leukopenia and reduced T‐cell fitness.
Hanna Kuhn, Felix Korell, Angela Hückelhoven‐Krauss, Brigitte Neuber, Miriam Stenzinger, Anita Ludwig‐Husemann, Maria‐Luisa Schubert, Patrick Derigs, Kiavasch Farid, Tim Sauer, Sandra Sauer, Carsten Müller‐Tidow, Peter Dreger, Michael Schmitt, Anita Schmitt   +14 more
wiley   +1 more source

Development and Evaluation of the Gathas Game as a Therapeutic Resource in Working With Psychoactive Substance Users

Counselling and Psychotherapy Research, Volume 26, Issue 2, June 2026.
ABSTRACT Background The increasing prevalence of psychoactive substance use and its associated disorders necessitates innovative and engaging therapeutic interventions. This study presents the Gathas Game, a gamified therapeutic tool designed to support individuals in substance use treatment by integrating principles from Cognitive Behavioural Therapy (
Dan Roger Pozza, Leonardo Möller Pedroso de Souza, Carmen Moret‐Tatay, Irani Iracema de Lima Argimon   +3 more
wiley   +1 more source

Supercritical‐flow structures in a Cretaceous submarine channel–lobe transition zone, Point Loma Formation, California

The Depositional Record, Volume 12, Issue 3, June 2026.
We document meter‐scale antidune and cyclic‐step deposits in channel–lobe transition zone (CLTZ) deposits of the Upper Cretaceous Point Loma Formation in San Diego, California. These results provide new insights into sediment transport dynamics in CLTZ environments, which are critical for understanding reservoir connectivity and heterogeneity in ...
Luthfi Saifudin, Zane Jobe, Arnoud Slootman, Mary Carr, Piret Plink‐Björklund   +4 more
wiley   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Marine Parasite Biogeography Mirrors Host Patterns Across Latitude, Area, and Diversity

New Zealand Journal of Zoology, Volume 53, Issue 2, June 2026.
Parasites are integral components of biodiversity, yet they remain poorly represented in large‐scale biogeographic theory. In this study, we test whether marine parasites follow three macroecological patterns established for free‐living taxa, namely that parasite species richness: (1) scales positively with area (both host body size and geographic area)
Thomas C. Morris, Mark John Costello, Nicholas J. Matzke   +2 more
wiley   +1 more source