Results 201 to 210 of about 21,251,406 (232)

MXene-integrated microneedles reprogram diabetic-associated macrophages for deep-wound infection therapy and immunoprotection. [PDF]

J Nanobiotechnology
Li W, Wang L, Zhao H, Zhang R, Zhang Y, Lin S, Qin H, Zong X, Gan K, Wang J, Yin H, Chen Y, Li R.   +12 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

Identification and characterization of two mtf-1 genes in common carp

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2008
The Metal-responsive Transcription Factor (MTF-1) serves as an essential regulator of Zn(2+) homeostasis via the activation of metallothionein gene expression. Only a single mtf-1 gene has been identified in any organism investigated previously. We report here the first evidence of the existence of two genes encoding MTF-1 proteins (mtf-1.1 and mtf-1.2)
Agnes, Ferencz, Edit, Hermesz
openaire   +2 more sources

Hypoxia acts through multiple signaling pathways to induce metallothionein transactivation by the metal-responsive transcription factor-1 (MTF-1)

Biochemistry and Cell Biology, 2011
Metal-responsive transcription factor-1 (MTF-1) is essential for the induction of genes encoding metallothionein by metals and hypoxia. Here, we studied the mechanism controlling the activation of MTF-1 by hypoxia.
Carl Seguin
exaly   +2 more sources

Characterization of the MTF-1 transcription factor from zebrafish and trout cells

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000
The metal response element (MRE)-binding transcription factor-1, MTF-1, is a zinc-responsive protein that controls transcription of metallothionein (MT) genes in many cell types. In addition, MTF-1 is also hypothesized to regulate transcription of a battery of genes involved in the defense against oxidative stress.
T P, Dalton, W A, Solis, D W, Nebert, M J, Carvan   +3 more
openaire   +2 more sources

Comparative analysis of MTF-1 binding sites between human and mouse

Mammalian Genome, 2010
MTF-1 is a crucial transcription factor involved in the cellular response to heavy-metal load and other stresses by specifically binding to metal response elements (MREs). Thus far only a handful of direct target genes are known for this transcription factor, limiting our understanding of the biological network it governs.
Minghui, Wang, Fan, Yang, Xiangzhe, Zhang, Hongbo, Zhao, Qishan, Wang, Yuchun, Pan   +5 more
openaire   +2 more sources

Zinc suppresses hepatic Zip10 expression through activation of MTF‐1

The FASEB Journal, 2007
The Zip transporter family acts to increase the intracellular zinc concentration. The mechanisms of regulation are largely unknown. Recently, hepatic Zip10 expression was shown to increase in vivo in the absence of metal‐responsive transcription factor‐1 (MTF‐1).
Louis A. Lichten, Juan P. Liuzzi, Robert J. Cousins   +2 more
openaire   +1 more source

Cellular zinc sensors: MTF-1 regulation of gene expression

Biometals, 2001
Zinc metabolism in higher eukaryotes is complex, being controlled by uptake, efflux, and storage in individual cells, as well as in peripheral tissues and organs. Recently there have been advances in the understanding of the genes involved in these processes and their regulation.
openaire   +2 more sources

Induction of Fetal Hemoglobin by Transcriptional Co-Activators MTF-1 and TSPYL1

Blood, 2011
Abstract Abstract 353 Sickle cell disease (SCD) impacts one of 400 African-Americans born each year. Augmentation of fetal hemoglobin (HbF) levels is widely accepted as the most effective method for treating SCD, but hydroxyurea (HU) is currently the only approved drug that increases HbF.
Kenneth R Peterson, Flavia C Costa, Halyna Fedosyuk, Renee Neades, Johana Bravo de los Rios, Andrea Fonteles, Lesya Zelenchuk, Prarthana Dalal, Gabriella Maniscalco   +8 more
openaire   +1 more source

Novel responses of ZRF, a variant of human MTF-1, to in vivo treatment with heavy metals

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2000
Heavy metal-dependent transcriptional activation of metallothionein (MT) genes is mediated by multiple enhancer sequences, metal responsive element (MRE), located in the upstream region of the genes. Previously, we have reported purification of a zinc-dependent MRE-binding protein, zinc regulatory factor (ZRF), from HeLa cells, and have pointed to the ...
F, Otsuka, I, Okugaito, M, Ohsawa, A, Iwamatsu, K, Suzuki, S, Koizumi   +5 more
openaire   +2 more sources

Analysis of the heavy metal-responsive transcription factor MTF-1 from human and mouse

Somatic Cell and Molecular Genetics, 1995
Heavy metal-induced transcription in mammalian cells is conferred by the metal-responsive 70 kDa transcription factor MTF-1 which contains six zinc fingers and at least three activation domains. In previous cell transfection experiments we have shown that the zinc finger region confers an about 3 fold metal inducibility of transcription, due to its ...
Müller HP, Brungnera E, Georgiev O, Badzong M, Müller KH, Schaffner W   +5 more
openaire   +3 more sources