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Target gene search for the metal-responsive transcription factor MTF-1 [PDF]
Nucleic Acids Research, 2001 Activation of genes by heavy metals, notably zinc, cadmium and copper, depends on MTF-1, a unique zinc finger transcription factor conserved from insects to human. Knockout of MTF-1 in the mouse results in embryonic lethality due to liver decay, while knockout of its best characterized target genes, the stress-inducible metallothionein genes I and II ...
Ragna Sack
exaly +4 more sources
Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1 [PDF]
EMBO Journal, 1998 We have shown previously that the heavy metal-responsive transcriptional activator MTF-1 regulates the basal and heavy metal-induced expression of metallothioneins. To investigate the physiological function of MTF-1, we generated null mutant mice by targeted gene disruption. Embryos lacking MTF-1 die in utero at approximately day 14 of gestation.
Rainer L Heuchel +2 more
exaly +4 more sources
Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione [PDF]
Nucleic Acids Research, 2005 Metal-responsive transcription factor 1 (MTF-1) regulates expression of its target genes in response to various stress conditions, notably heavy metal load, via binding to metal response elements (MREs) in the respective enhancer/promoter regions. Furthermore, it serves a vital function in embryonic liver development. However, targeted deletion of Mtf1
Walter Schaffner
exaly +4 more sources
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Comparative analysis of MTF-1 binding sites between human and mouse
Mammalian Genome, 2010MTF-1 is a crucial transcription factor involved in the cellular response to heavy-metal load and other stresses by specifically binding to metal response elements (MREs). Thus far only a handful of direct target genes are known for this transcription factor, limiting our understanding of the biological network it governs.
Minghui, Wang +5 more
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Identification and characterization of two mtf-1 genes in common carp
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2008The Metal-responsive Transcription Factor (MTF-1) serves as an essential regulator of Zn(2+) homeostasis via the activation of metallothionein gene expression. Only a single mtf-1 gene has been identified in any organism investigated previously. We report here the first evidence of the existence of two genes encoding MTF-1 proteins (mtf-1.1 and mtf-1.2)
Agnes, Ferencz, Edit, Hermesz
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Characterization of the MTF-1 transcription factor from zebrafish and trout cells
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000The metal response element (MRE)-binding transcription factor-1, MTF-1, is a zinc-responsive protein that controls transcription of metallothionein (MT) genes in many cell types. In addition, MTF-1 is also hypothesized to regulate transcription of a battery of genes involved in the defense against oxidative stress.
T P, Dalton +3 more
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Zinc suppresses hepatic Zip10 expression through activation of MTF‐1
The FASEB Journal, 2007The Zip transporter family acts to increase the intracellular zinc concentration. The mechanisms of regulation are largely unknown. Recently, hepatic Zip10 expression was shown to increase in vivo in the absence of metal‐responsive transcription factor‐1 (MTF‐1).
Louis A. Lichten +2 more
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Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.
The EMBO Journal, 1993Metallothioneins (MTs) are small cysteine-rich proteins whose structure is conserved from fungi to man. MTs strongly bind heavy metals, notably zinc, copper and cadmium. Upon exposure of cells to heavy metal and other adverse treatments, MT gene transcription is strongly enhanced.
F, Radtke +6 more
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Cellular zinc sensors: MTF-1 regulation of gene expression
Biometals, 2001Zinc metabolism in higher eukaryotes is complex, being controlled by uptake, efflux, and storage in individual cells, as well as in peripheral tissues and organs. Recently there have been advances in the understanding of the genes involved in these processes and their regulation.
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Induction of Fetal Hemoglobin by Transcriptional Co-Activators MTF-1 and TSPYL1
Blood, 2011Abstract Abstract 353 Sickle cell disease (SCD) impacts one of 400 African-Americans born each year. Augmentation of fetal hemoglobin (HbF) levels is widely accepted as the most effective method for treating SCD, but hydroxyurea (HU) is currently the only approved drug that increases HbF.
Kenneth R Peterson +8 more
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