Results 211 to 220 of about 21,251,406 (232)

Identification of a splice variant of the metal-responsive transcription factor MTF-1 in common carp

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2009
Transactivation of the expression of metallothionein genes involves the Metal-responsive Transcription Factor (MTF-1). We report here the identification of mtf-1.1a, the first known splice variant of mtf-1.1 mRNA, in common carp (Cyprinus carpio).
Agnes, Ferencz, Edit, Hermesz
openaire   +2 more sources

Cloned transcription factor MTF-1 activates the mouse metallothionein I promoter.

The EMBO Journal, 1993
Metallothioneins (MTs) are small cysteine-rich proteins whose structure is conserved from fungi to man. MTs strongly bind heavy metals, notably zinc, copper and cadmium. Upon exposure of cells to heavy metal and other adverse treatments, MT gene transcription is strongly enhanced.
F, Radtke, R, Heuchel, O, Georgiev, M, Hergersberg, M, Gariglio, Z, Dembic, W, Schaffner   +6 more
openaire   +2 more sources

Putting its fingers on stressful situations: the heavy metal‐regulatory transcription factor MTF‐1

BioEssays, 2001
AbstractIt has been suggested that metallothioneins, discovered about 45 years ago, play a central role in heavy metal metabolism and detoxification, and in the management of various forms of stress. The metal‐regulatory transcription factor‐1 (MTF‐1) was shown to be essential for basal and heavy metal‐induced transcription of the stress‐responsive ...
Lichtlen P, Schaffner W
openaire   +3 more sources

Regulation of malignant progression by the hypoxia-sensitive transcription factors HIF-1α and MTF-1

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2004
Solid tumors are known to develop microenvironmental hypoxia or anoxia due to malfunction and malformation of blood vessels and the energy demands of the highly proliferative tumor cells. Oxygen deprivation can cause aberrant modifications of signaling pathways and their downstream transcription factors that are believed to contribute to malignancy ...
openaire   +2 more sources

Metal Response Element (MRE)-Binding Transcription Factor-1 (MTF-1): Structure, Function, and Regulation

Antioxidants & Redox Signaling, 2001
Metal-responsive control of the expression of genes involved in metal metabolism and metal homeostasis allows an organism to tightly regulate the free or bioavailable concentration of beneficial metal ions, such as zinc, copper, and iron, within an acceptable range, while efficiently removing nonbeneficial or toxic metals.
D P, Giedroc, X, Chen, J L, Apuy
openaire   +2 more sources

Zinc-sensitive genes as potential new target genes of the metal transcription factor-1 (MTF-1)

Biochemistry and Cell Biology, 2005
Zinc is an essential trace element that serves as a structural constituent of a large number of transcription factors, which explains its pivotal role in the control of gene expression. Previous studies investigating the effect of zinc deficiency and zinc supplementation on gene expression in the human adenocarcinoma cell line HT-29 led to the ...
Birgit, Kindermann, Frank, Döring, Jan, Budczies, Hannelore, Daniel   +3 more
openaire   +2 more sources

MTF-1

1998
Tak W. Mak, Josef Penninger, John Roder, Janet Rossant, Mary Saunders   +4 more
openaire   +1 more source

Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco

Chemosphere, 2020
Guang-Hui Chen, Wu-Hong Lv, Yi-Huan Xu   +2 more
exaly  

NMR assignment of the six zinc fingers of MTF-1 in the free and DNA-bound states

Journal of Biomolecular NMR, 2005
Belinda M, Potter, Nathan A, Knudsen, Linda S, Feng, Viktor A, Matskevich, Jed A, Wilson, Glen K, Andrews, John H, Laity   +6 more
openaire   +2 more sources

MTF Measurement by Slanted-Edge Method Based on Improved Zernike Moments

Sensors, 2023
Fengyan Wang, Zhang Shuo, Wang Fengyan   +2 more
exaly