Results 211 to 220 of about 13,421 (232)
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Antioxidants & Redox Signaling, 2001
Metal-responsive control of the expression of genes involved in metal metabolism and metal homeostasis allows an organism to tightly regulate the free or bioavailable concentration of beneficial metal ions, such as zinc, copper, and iron, within an acceptable range, while efficiently removing nonbeneficial or toxic metals.
D P, Giedroc, X, Chen, J L, Apuy
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Metal-responsive control of the expression of genes involved in metal metabolism and metal homeostasis allows an organism to tightly regulate the free or bioavailable concentration of beneficial metal ions, such as zinc, copper, and iron, within an acceptable range, while efficiently removing nonbeneficial or toxic metals.
D P, Giedroc, X, Chen, J L, Apuy
openaire +2 more sources
Analysis of the heavy metal-responsive transcription factor MTF-1 from human and mouse
Somatic Cell and Molecular Genetics, 1995Heavy metal-induced transcription in mammalian cells is conferred by the metal-responsive 70 kDa transcription factor MTF-1 which contains six zinc fingers and at least three activation domains. In previous cell transfection experiments we have shown that the zinc finger region confers an about 3 fold metal inducibility of transcription, due to its ...
H P, Müller +5 more
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Putting its fingers on stressful situations: the heavy metal‐regulatory transcription factor MTF‐1
BioEssays, 2001AbstractIt has been suggested that metallothioneins, discovered about 45 years ago, play a central role in heavy metal metabolism and detoxification, and in the management of various forms of stress. The metal‐regulatory transcription factor‐1 (MTF‐1) was shown to be essential for basal and heavy metal‐induced transcription of the stress‐responsive ...
P, Lichtlen, W, Schaffner
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Archives of Biochemistry and Biophysics, 2007
The regulation of divalent zinc has been observed in a wide range of organisms. Since this metal is an essential nutrient, but also toxic in excess, zinc homeostasis is crucial for normal cellular functioning. The metal-responsive-element-binding transcription factor-1 (MTF-1) is a key regulator of zinc in higher eukaryotes ranging from insects to ...
John H, Laity, Glen K, Andrews
exaly +3 more sources
The regulation of divalent zinc has been observed in a wide range of organisms. Since this metal is an essential nutrient, but also toxic in excess, zinc homeostasis is crucial for normal cellular functioning. The metal-responsive-element-binding transcription factor-1 (MTF-1) is a key regulator of zinc in higher eukaryotes ranging from insects to ...
John H, Laity, Glen K, Andrews
exaly +3 more sources
Zinc-sensitive genes as potential new target genes of the metal transcription factor-1 (MTF-1)
Biochemistry and Cell Biology, 2005Zinc is an essential trace element that serves as a structural constituent of a large number of transcription factors, which explains its pivotal role in the control of gene expression. Previous studies investigating the effect of zinc deficiency and zinc supplementation on gene expression in the human adenocarcinoma cell line HT-29 led to the ...
Birgit, Kindermann +3 more
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Identification of a splice variant of the metal-responsive transcription factor MTF-1 in common carp
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2009Transactivation of the expression of metallothionein genes involves the Metal-responsive Transcription Factor (MTF-1). We report here the identification of mtf-1.1a, the first known splice variant of mtf-1.1 mRNA, in common carp (Cyprinus carpio).
Agnes, Ferencz, Edit, Hermesz
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Regulation of malignant progression by the hypoxia-sensitive transcription factors HIF-1α and MTF-1
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2004Solid tumors are known to develop microenvironmental hypoxia or anoxia due to malfunction and malformation of blood vessels and the energy demands of the highly proliferative tumor cells. Oxygen deprivation can cause aberrant modifications of signaling pathways and their downstream transcription factors that are believed to contribute to malignancy ...
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MTF Measurement by Slanted-Edge Method Based on Improved Zernike Moments
Sensors, 2023Fengyan Wang
exaly