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Metallothionein: A Comprehensive Review of Its Classification, Structure, Biological Functions, and Applications

Antioxidants
Metallothionein is a cysteine-rich protein with a high metal content that is widely found in nature. In addition to heavy metal detoxification, metallothionein is well known as a potent antioxidant.
Nan Shang, Li Pinglan
exaly   +3 more sources

Metallothionein Protein Modeling from Pseudomonas aeruginosa PAO1 as A Metal Biosorber Candidate

Jurnal Biodjati, 2023
Metallothionein is a protein that is well known to play a role in metal metabolism in bacterial cells. Metallothionein is a multifunctional protein that has the potential to be used as a metal adsorbing agent.
Fajri Ikhsan, Ahmad Shulhany, Syarif Abdullah   +2 more
doaj   +1 more source

Downregulation of metallothionein-2 contributes to oxaliplatin-induced neuropathic pain

Journal of Neuroinflammation, 2021
Background We previously reported a correlation between small doses of oxaliplatin penetrating onto the spinal cord and acute pain after chemotherapy. Here, we propose that MT2 within the spinal dorsal horns participates in the development of oxaliplatin-
Xuelin Huang, Jie Deng, Ting Xu, Wenjun Xin, Yuehong Zhang, Xiangcai Ruan   +5 more
doaj   +1 more source

Metallothionein levels on the gill and liver of Mystus nigriceps (Valenciennes, 1840) in Welang River, Pasuruan City, East Java

Depik Jurnal, 2022
This research was conducted in October 2021 using a survey method. Sampling was carried out three times with a span of every 2 weeks at 3 stations along the lower reaches of the Welang River Pasuruan Regency.
Lisma Wardani, Endang Yuli Herawati, Asus Maizar Surya   +2 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Exacerbation of Elastase-Induced Emphysema via Increased Oxidative Stress in Metallothionein-Knockout Mice

Biomolecules, 2022
Although the pathogenesis of chronic obstructive pulmonary disease (COPD) is not yet fully understood, recent studies suggest that the disruption of the intracellular balance of oxidative (such as reactive oxygen species (ROS)) and antioxidant molecules ...
Ken Ichiro Tanaka, Sachie Shiota, Okina Sakakibara, Mikako Shimoda, Ayaka Takafuji, Misaki Takabatake, Yoshito Kadota, Takashige Kawakami, Shinya Suzuki, Masahiro Kawahara   +9 more
doaj   +1 more source

Relationship between Metallothionein and Mercury (Hg) in the Gill Tissue of the Barbonymus altus in the Brantas River Jombang, East Java

Journal of Experimental Life Science, 2023
Pollution of river waters is most often the result of human activities in managing agricultural land, industry, and transportation. The entry of pollutants such as heavy metal mercury (Hg) into the waters can interfere with the survival of fish waters ...
Aang Setyawan Anjasmara, Asus Maizar Suryanto Hertika, Uun Yanuhar   +2 more
doaj   +1 more source

Metallothionein Expression and its Influence on the In Vitro Biological Behavior of Mucoepidermoid Carcinoma

Cells, 2020
Mucoepidermoid carcinoma (MEC) is the most common tumor in the salivary glands, often presenting with recurrence and metastasis due to its high invasive capacity.
João Rafael Habib Souza Aquime, Lara Carolina D’Araújo Pinto Zampieri, Maria Sueli da Silva Kataoka, Nelson Antonio Bailão Ribeiro, Ruy Gastaldoni Jaeger, Artur Luiz da Silva, Rommel Thiago Jucá Ramos, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro   +8 more
doaj   +1 more source

Density and intensity of metallothionein of Crassostrea sp. as biomarkers of heavy metal contamination in the Northern coast of East Java, Indonesia

Egyptian Journal of Aquatic Research, 2021
The present study aimed to observe the expression level of metallothionein by analyzing its density and intensity in the gill and stomach of Crassostrea glomerata and Crassostrea iredalei.
Asus Maizar Suryanto Hertika, Kusriani Kusriani, Erlinda Indrayani, Renanda Baghaz Dzulhamdhani Surya Putra   +3 more
doaj   +1 more source

Metallothionein expression in feline injection site fibrosarcomas

BMC Veterinary Research, 2023
Background Feline injection site fibrosarcoma is an aggressive and infiltrative tumour arising in the background of chronic inflammation. The aim of this study was to evaluate the expression of metallothionein (I-II) in feline injection site ...
Mateusz Mikiewicz, Katarzyna Paździor-Czapula, Joanna Fiedorowicz, Michał Gesek, Iwona Otrocka-Domagała   +4 more
doaj   +1 more source